Abstract:
OBJECTIVE:This study aims to assess the role of mental-orientation in the diagnosis of mild cognitive impairment and Alzheimer's disease using a novel task. METHOD:A behavioral study (Experiment 1) compared the mental-orientation task to standard neuropsychological tests in patients across the Alzheimer's disease spectrum. A functional MRI study (Experiment 2) in young adults compared activations evoked by the mental-orientation and standard-orientation tasks as well as their overlap with brain regions susceptible to Alzheimer's disease pathology. RESULTS:The mental-orientation task differentiated mild cognitively impaired and healthy controls at 95% accuracy, while the Addenbrooke's Cognitive Examination, Mini-Mental State Examination and standard-orientation achieved 74%, 70% and 50% accuracy, respectively. Functional MRI revealed the mental-orientation task to preferentially recruit brain regions exhibiting early Alzheimer's-related atrophy, unlike the standard-orientation test. CONCLUSIONS:Mental-orientation is suggested to play a key role in Alzheimer's disease, and consequently in early detection and follow-up of patients along the Alzheimer's disease spectrum. (PsycINFO Database Record
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Peters-Founshtein G,Peer M,Rein Y,Kahana Merhavi S,Meiner Z,Arzy Sdoi
10.1037/neu0000463subject
Has Abstractpub_date
2018-09-01 00:00:00pages
690-699issue
6eissn
0894-4105issn
1931-1559pii
2018-23212-001journal_volume
32pub_type
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