Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography study.

Abstract:

:Delayed alternation tasks are frequently used as probes of frontal lobe functioning. To clarify the neural substrates of delayed alternation performance in humans, the authors measured regional cerebral blood flow with H2(15)O positron emission tomography in healthy subjects as they performed delayed spatial and object alternation. Consistent with the monkey lesion literature, increased dorsolateral prefrontal activity emerged during delayed spatial alternation but not delayed object alternation, whereas orbitofrontal activations emerged in both alternation tasks. The possible cognitive processes contributing to the orbitofrontal and dorsolateral prefrontal involvement in delayed alternation are discussed. Additional activations localized to several nonfrontal regions suggest caution in interpreting alternation deficits in patients as strictly reflecting frontal lobe impairment.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Zald DH,Curtis C,Folley BS,Pardo JV

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

182-9

issue

2

eissn

0894-4105

issn

1931-1559

journal_volume

16

pub_type

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