Spectra of spontaneous growth-dependent and adaptive mutations at ebgR.

Abstract:

:A comparison of the spectra of spontaneous growth-dependent and adaptive mutations in ebgR shows that both spectra are dominated by insertion sequence (IS)-mediated mutations. The difference between growth-dependent mutations (61% IS mediated) and adaptive mutations (80% IS mediated) is highly significant (P < 0.0001). In contrast, the spectra of growth-dependent and adaptive non-IS-mediated mutations do not differ from each other and therefore do not provide support for the hypothesis that adaptive and growth-dependent mutations arise by substantially different mechanisms.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Hall BG

doi

10.1128/JB.181.4.1149-1155.1999

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

1149-55

issue

4

eissn

0021-9193

issn

1098-5530

journal_volume

181

pub_type

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