Mutagenesis of Neisseria gonorrhoeae: absence of error-prone repair.

Abstract:

:The lethal and mutagenic effects of various mutagens on Neisseria gonorrhoeae were investigated. Lethality studies demonstrated that N. gonorrhoeae was relatively sensitive to ethyl methanesulfonate, UV light, and methyl methanesulfonate. Although N. gonorrhoeae was readily mutated by ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine for the three genetic markers assayed, no increase in the mutation frequency was observed for any of the selective markers after UV irradiation or methyl methanesulfonate treatment. These results suggest that N. gonorrhoeae lacks an error-prone repair mechanism.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Campbell LA,Yasbin RE

doi

10.1128/JB.160.1.288-293.1984

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

288-93

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

160

pub_type

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