Staphylococcus aureus YoeB homologues inhibit translation initiation.

Abstract:

:YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin system found in various bacterial genomes. Here, we show that Staphylococcus aureus contains two YoeB homologues, both of which function as ribosome-dependent mRNA interferases to inhibit translation initiation in a manner identical to that of YoeB-ec from Escherichia coli.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Yoshizumi S,Zhang Y,Yamaguchi Y,Chen L,Kreiswirth BN,Inouye M

doi

10.1128/JB.00623-09

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

5868-72

issue

18

eissn

0021-9193

issn

1098-5530

pii

JB.00623-09

journal_volume

191

pub_type

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