Effects of deoxyribonucleic acid products on deoxyribonucleic acid synthesis of virulent and avirulent pneumococci.

Abstract:

:Firshein, W. (Wesleyan University, Middletown, Conn.). Effects of deoxyribonucleic acid products on deoxyribonucleic acid synthesis of virulent and avirulent pneumococci. J. Bacteriol. 82:169-180. 1961.-Cell suspensions of virulent pneumococci synthesize a greater amount of deoxyribonucleic acid (DNA) per cell in the presence of DNA + deoxyribonuclease + mixtures of deoxynucleosides and deoxynucleotides (supplement-1) than unsupplemented suspensions. Under identical conditions, avirulent and weakly virulent pneumococci do not respond to these DNA breakdown products. Glucose and casitone must be present for maximal effects to occur.A DNA turnover occurs in virulent cells. This has been demonstrated by a decrease in specific activity of H(3)-DNA extracted from virulent (S) cells exposed to nonradioactive supplement-1.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

FIRSHEIN W

doi

10.1128/JB.82.2.169-180.1961

keywords:

subject

Has Abstract

pub_date

1961-08-01 00:00:00

pages

169-80

eissn

0021-9193

issn

1098-5530

journal_volume

82

pub_type

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