An epigenetic switch mediates bistable expression of the type 1 pilus genes in Streptococcus pneumoniae.

Abstract:

:Expression of the pneumococcal type 1 pilus is bistable and positively regulated by the transcription factor RlrA. RlrA is also known to positively control its own expression. Here we present evidence that bistable expression of the type 1 pilus is mediated by the positive-feedback loop controlling rlrA expression.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Basset A,Turner KH,Boush E,Sayeed S,Dove SL,Malley R

doi

10.1128/JB.06078-11

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

1088-91

issue

5

eissn

0021-9193

issn

1098-5530

pii

JB.06078-11

journal_volume

194

pub_type

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