Do subchondral bone changes exacerbate or precede articular cartilage destruction in osteoarthritis of the elderly?

abstract：BACKGROUND:Although white matter changes visible with MRI are generally considered to result from ischemia, it has become clear that these changes also appear in patients with Alzheimer's disease (AD). However, their significance in AD is unknown. OBJECTIVE:We evaluated the clinical significance of white matter change...

journal_title：Gerontology

authors： Kono I,Mori S,Nakajima K,Nakagawa M,Watanabe Y,Kizu O,Yamada K,Sakai Y

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Cardiac surgery is widely believed to be an excessively high-risk intervention for very elderly patients with coronary artery or valvular disease. However, as life expectancy and the prospect of sustained quality of life into older age increase, this assumption should be challenged so that surgery is not den...

journal_title：Gerontology

authors： Guilfoyle MR,Drain AJ,Khan A,Ferguson J,Large SR,Nashef SA

更新日期：2010-01-01 00:00:00

abstract：:We studied the correlation between the in vitro lymphocyte proliferative response and some early parameters of lymphocyte activation in aged people. While a consistent number of elderly subjects showed significantly decreased proliferative responses to mitogen stimulation, interleukin-1 (IL-1) production and IL-2 rece...

journal_title：Gerontology

authors： Amadori A,Zanovello P,Cozzi E,Ciminale V,Borghesan F,Fagiolo U,Crepaldi G

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Six-metre walking speed (SMWS) is a commonly used test for measuring functional performance in older people. However, apart from lower limb strength, few studies have examined the range of physiological and psychological factors that influence performance in this test. OBJECTIVE:To investigate the relative ...

journal_title：Gerontology

authors： Tiedemann A,Sherrington C,Lord SR

更新日期：2005-11-01 00:00:00

abstract：:New neurons are continuously generated and added to neural circuits in the adult brain. However, increasing age imposes changes in neural progenitor cells and their microenvironment that lead to a reduction of neurogenesis. Age-related decreased production of new neurons in the neurogenic dentate gyrus has been associ...

journal_title：Gerontology

authors： Seib DR,Martin-Villalba A

更新日期：2015-01-01 00:00:00

abstract：:Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because ...

journal_title：Gerontology

authors： Yu KR,Kang KS

更新日期：2013-01-01 00:00:00

abstract：:Phagocytically stimulated canine leukocyte suspensions obtained from 12 young adult and 43 aged individuals were examined for several physiological manifestations of the phagocytically induced respiratory burst. There was considerable variation in levels of oxygen consumption, glucose oxidation via the hexose monophos...

journal_title：Gerontology

authors： Johnson DD,Renshaw HW,Warner DH,Browder EJ,Williams JD

更新日期：1984-01-01 00:00:00

abstract：:We examined age- and diet-related alterations in RNA poly(A) tail length using high-resolution gel electrophoresis followed by Northern hybridization. The results demonstrate conclusively that there is no age-related decrease in the size of the Poly(A) tail of RNA isolated from the male Fischer 344 rat. In contrast, o...

journal_title：Gerontology

authors： Kristal BS,Conrad CC,Richarson A,Yu BP

更新日期：1993-01-01 00:00:00

abstract：:This review focuses on 3 allergic disorders of persons coming up against venerable age: asthma, allergic rhinitis, and atopic dermatitis. The prevalence of allergic diseases in the elderly ranges from 5 to 10% and appears to be rising. A gradual decline in immune function, termed immunosenescence, and age-related chan...

journal_title：Gerontology

authors： Milgrom H,Huang H

更新日期：2014-01-01 00:00:00

abstract：:Typically, subjective memory assessments (be it in form of single items or questionnaires) in old age only weakly correlate with the performance in objective memory tests at cross-section. It thus appears as if individual differences in subjective memory assessments hardly reflect individual differences in memory in o...

journal_title：Gerontology

authors： Zimprich D,Kurtz T

更新日期：2015-01-01 00:00:00

abstract：:Creatine phosphokinase (CPK) has been shown to provide the initial ATP for muscle contraction. The effect of wheel running on CPK levels was compared in hindleg and cardiac muscles of young, intermediate-age and old outbred CW-1 and inbred C57BL mice. Short-term (5 weeks) and long-term (over 12 months) regimens were u...

journal_title：Gerontology

authors： Steinhagen-Thiessen E,Reznick AZ

更新日期：1987-01-01 00:00:00

abstract：:We performed 24-hour ambulatory electrocardiographic (Holter) examinations in 50 retired hospital workers (30 men, 20 women), aged 58-85 years (mean age +/- SD: 65.9 +/- 4.6 years), with a normal clinical history, physical examination and baseline ECG. There was a significant difference between daytime and nocturnal m...

journal_title：Gerontology

authors： Ribera JM,Cruz AJ,Zamorano JL,Pérez-Casar F

更新日期：1989-01-01 00:00:00

abstract：:Alloxan diabetes in Swiss mice of both sexes accelerated the ageing of collagen in newly formed cotton pellet granuloma concomitant with its similar effect on dorsal skin. The degree of response of collagen to alloxanization was dependent on the duration of the treatment and the sex of the animal. It is suggested that...

journal_title：Gerontology

authors： Behera HN,Patnaik BK

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Adults aged 65 years and older stand to benefit from the accumulating wealth of Internet-based health resources, including online interventions to assist in the self-management of chronic health conditions. However, concerns have been expressed that lesser Internet use and familiarity among older adults may ...

journal_title：Gerontology

authors： Crabb RM,Rafie S,Weingardt KR

更新日期：2012-01-01 00:00:00

abstract：:One of the problems associated with using random-source dogs to study in vivo vascular responses is their unknown background. Since aging is known to influence vascular responses, unknown variations in age could influence experimental results. The vast majority of aging studies examine arteries in vitro. This study wa...

journal_title：Gerontology

authors： Kaiser L,Ptu S

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:In Japan, vascular dementia (VD) has been responsible for the majority of all dementia cases in both epidemiological and neuropathological studies. Recently, however, several epidemiological investigations have shown that the rate of VD has decreased and senile dementia of the Alzheimer type (SDAT) is now th...

journal_title：Gerontology

authors： Seno H,Ishino H,Inagaki T,Iijima M,Kaku K,Inata T

更新日期：1999-01-01 00:00:00

abstract：:The purpose of this study was to examine the effects of a multifactorial memory training program designed for normal older adults. The multifactorial program involved the training of three components that are critical to memory functioning: recoding operations, attentional functions and relaxation. Two controls groups...

journal_title：Gerontology

authors： Stigsdotter A,Bäckman L

更新日期：1989-01-01 00:00:00

abstract：:A mathematical model of survivorship kinetics is presented. It takes into account both deterministic and stochastic aspects of survival curves. Earlier reports [Piantanelli: Arch Gerontol Geriatr 1986;5:107-118; Piantanelli: Ann NY Acad Sci 1988; 521:99-109] described a model capable of making distinct predictions on ...

journal_title：Gerontology

authors： Piantanelli L,Rossolini G,Nisbet R

更新日期：1992-01-01 00:00:00

abstract：:Hyposplenism has been reported in elderly people. However, from previous studies, it was not clear whether the observed alterations in splenic function were a physiologic effect of advanced age itself or a consequence of age-related diseases. As hyposplenism is believed to predispose to infections, autoimmune phenomen...

journal_title：Gerontology

authors： Ravaglia G,Forti P,Biagi F,Maioli F,Boschi F,Corazza GR

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:Declines in physical fitness can notably affect healthy aging of older adults. Multimodal exercise training regimen such as mind-body interventions (MBIs) has been reported to mitigate these aging-related declines of physical function. This meta-analytical review aimed at pooling the effects of MBIs on phy...

journal_title：Gerontology

authors： Ebner SA,Meikis L,Morat M,Held S,Morat T,Donath L

更新日期：2021-01-27 00:00:00

abstract：:Older adults often face challenges as they transition out of the acute care hospital, especially with regard to adhering to their medications. In this narrative review, we discuss medication adherence in older adults across the continuum of care, describing reasons for nonadherence, methods to assess adherence and too...

journal_title：Gerontology

authors： Mixon AS,Neal E,Bell S,Powers JS,Kripalani S

更新日期：2015-01-01 00:00:00

abstract：:Acquisition of immunologic self-tolerance by clonal deletion in the thymus is concluded to be a critical process in immune aging and is found to be transiently protected from genetic instability by means of a feedback surveillance which functions at the expense of chronic thymic involution. In the immune control of ma...

journal_title：Gerontology

authors： Hartwig M

更新日期：1994-01-01 00:00:00

abstract：:Adhesion molecules, such as leukocyte-function-associated antigen (LFA-1 or CD11a/CD18), intercellular adhesion molecule 1 (ICAM-1 or CD54) and Hermes antigen (HCAM or CD44), have important roles in many adhesive interactions involving cells of the immune system. Since it has been shown that many immunological alterat...

journal_title：Gerontology

authors： Chiricolo M,Morini MC,Mancini R,Beltrandi E,Belletti D,Conte R

更新日期：1995-01-01 00:00:00

abstract：:To develop a new method for accurately predicting creatinine clearance (Ccr) in the debilitated elderly without urine collections, the total muscle volume of both thighs (MV thigh), as a new predictive parameter, was calculated using computed tomography in 68 debilitated patients aged 61-92 years. A regression line be...

journal_title：Gerontology

authors： Sanaka M,Takano K,Shimakura K,Koike Y,Mineshita S

更新日期：1995-01-01 00:00:00

abstract：:Historically, family ties have been understood as the primary source of support for aging adults, and past empirical and theoretical work has highlighted the tendency of older adults to focus on close family. However, in line with demographic changes and historical increases in the diversity of social structures, frie...

journal_title：Gerontology

authors： Fiori KL,Windsor TD,Huxhold O

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder in middle and late age. Ribosomal RNA (rRNA) genes are located in the nucleolus (nucleolar organizer regions = NORs). There are increased deposits of beta-amyloid protein in the brains of the patients with AD and aged individuals with Down's syndrome (...

journal_title：Gerontology

authors： Dönmez-Altuntaş H,Akalin H,Karaman Y,Demirtaş H,Imamoğlu N,Ozkul Y

更新日期：2005-09-01 00:00:00

abstract：:The effects of ovine corticotropin releasing factor (o-CRF) on the secretions of ACTH, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were studied in the healthy young and elderly male individuals. o-CRF caused significant elevations of plasma ACTH, cortisol and DHEA concentrations...

journal_title：Gerontology

authors： Ohashi M,Fujio N,Kato K,Nawata H,Ibayashi H

更新日期：1986-01-01 00:00:00

abstract：:We have previously shown that lymphocytes from Alzheimer's disease (AD) patients are hypersensitive to ionising radiation, as revealed by their higher levels of dicentrics than those from age-matched, normal individuals. We have now examined the sensitivity of these cells to N-methyl-N-nitrosourea or methyl methanesul...

journal_title：Gerontology

authors： Tobi SE,Neary D,Itzhaki RF

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The common cause account suggests that there is a third factor causing aging effects in both sensory and cognitive functioning, hypothesized to be the integrity of the central nervous system [Lindenberger and Baltes; Psychol Aging 1994;9:339-355]. Importantly, the common cause account was developed based on ...

journal_title：Gerontology

authors： Sternäng O,Jonsson B,Wahlin A,Nyberg L,Nilsson LG

更新日期：2010-01-01 00:00:00

abstract：:Mitochondrial abnormality in the skeletal muscles of 13 patients with myotonic dystrophy was analyzed by both histochemical and molecular biologic methods. Nine of 13 patients had ragged-red fibers (50 +/- 116 per 10,000 muscle fibers, mean +/- SD), and 10 patients had cytochrome c oxidase-negative fibers (41 +/- 90 p...

journal_title：Gerontology

authors： Sahashi K,Tanaka M,Tashiro M,Ohno K,Ibi T,Takahashi A,Ozawa T

更新日期：1992-01-01 00:00:00