Do white matter changes have clinical significance in Alzheimer's disease?

abstract：:The heat shock protein (HSP) system is a mechanism of cell defense induced by stress, constitutively expressed during basal conditions and essential to the maintenance of cellular integrity. Acutely induced HSP synthesis decreases with aging, but the effect of age on the basal expression of HSP70 has not been specific...

journal_title：Gerontology

authors： Maiello M,Boeri D,Sampietro L,Pronzato MA,Odetti P,Marinari UM

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Being able to rise from a chair is an important daily life activity that requires sufficient lower extremity muscle power and postural control. OBJECTIVE:To assess the effects of an individually tailored intervention on the chair rise capacity of active and inactive community-dwelling older men and women. ...

journal_title：Gerontology

authors： Tikkanen P,Lönnroos E,Sipilä S,Nykänen I,Sulkava R,Hartikainen S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Mortality in the intensive care unit (ICU) rises with age, a high basal serum cortisol and a small response to adrenocorticotropin (ACTH) stimulation. Even slight impairment of the adrenal response during severe illness can be lethal. OBJECTIVES:To determine if age is associated with changes in basal or sti...

journal_title：Gerontology

authors： Beale E,Zhu J,Belzberg H

更新日期：2002-03-01 00:00:00

abstract：INTRODUCTION:The identification of modifiable health span-promoting factors is a public health priority. OBJECTIVE:To explore the socio-environmental, lifestyle, behavioural, and psychological determinants of a clinical phenotypic measure of biological ageing in the Singapore Longitudinal Ageing Study (SLAS) cohort. ...

journal_title：Gerontology

authors： Ng TP,Zhong X,Gao Q,Gwee X,Chua DQL,Larbi A

更新日期：2020-01-01 00:00:00

abstract：:Age differences in decision-making are of theoretical interest and have important practical implications, but relevant lines of work are distributed across multiple disciplines and often lack integration. The present review proposes an overarching conceptual framework with the aim of connecting disjointed aspects of t...

journal_title：Gerontology

authors： Löckenhoff CE

更新日期：2018-01-01 00:00:00

abstract：:A retrospective study was made of 50 consecutive cases of bacteraemia treated in a geriatric unit. The mortality rate was 24%, the highest incidence occurring amongst the cases of hospital-acquired bacteraemia where only 1 of 7 cases survived the infection. Pyrexia, acute confusion, and falls were the commonest presen...

journal_title：Gerontology

authors： Windsor AC

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Orthostatic hypotension (OH) is common in older adults and associated with increased morbidity and mortality, loss of independence and high health-care costs. Standing up slowly is a recommended non-pharmacological intervention. However, the effectiveness of this advice has not been well studied. OBJECTIVES...

journal_title：Gerontology

authors： de Bruïne ES,Reijnierse EM,Trappenburg MC,Pasma JH,de Vries OJ,Meskers CG,Maier AB

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE AND BACKGROUND:The aim of the present article is to discuss the potential of gene therapy for thymic hormones as a novel therapeutic strategy to treat dyshomeostatic states associated with athymia, as Di George syndrome, or hypothymic conditions like those associated with AIDS, chronic stress or aging. First ...

journal_title：Gerontology

authors： Goya RG,Cónsole G,Hereñú C,Brown O,Rimoldi OJ

更新日期：2002-09-01 00:00:00

abstract：:The last 2 decades have brought an explosion of research, new products, and general attention to the problem of urinary urgency, and yet patients continue to be plagued by this symptom - especially the elderly. What is it? What does it mean? How can we guide patients successfully through this challenge? This paper pre...

journal_title：Gerontology

authors： Potts JM,Payne CK

更新日期：2018-01-01 00:00:00

abstract：:The interactions of ergot alkaloids and of other drugs with dopamine (DA) and alpha-adrenergic receptors were investigated. The tested ergot alkaloids inhibit synaptosomal tyrosine hydroxylase activity and reverse the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Thus, ergot alkaloids ...

journal_title：Gerontology

authors： Goldstein M,Lew JY,Hata F,Lieberman A

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Malnutrition is a widespread but largely unrecognized problem in aged patients, more so as it is a contributing factor to the increased morbidity and mortality in this age group. Since direct measurements of body composition are not possible in a large number of patients, good anthropometric reference data a...

journal_title：Gerontology

authors： Bonnefoy M,Jauffret M,Kostka T,Jusot JF

更新日期：2002-05-01 00:00:00

abstract：:Form birefringence curves and linear dichroic properties of aging rat tendons are different from those of adult controls. The steepness of the form birefringence curves and the increased retardations found in aging tendons are ascribed to an increase in collagen aggregation accompanied by loss of tissue water. Based o...

journal_title：Gerontology

authors： Mello ML,Vidal BC,de Carvalho AC,Caseiro-Filho AC

更新日期：1979-01-01 00:00:00

abstract：:Morphometric measurements have been carried out on the human myenteric esophageal neurons at the ages of 20-40 and more than 70 years. The number of neurons decreases after 70 years of age, which is accompanied by an increase in the sizes of the neurons. In percentage terms the decrease in the number of neurons in the...

journal_title：Gerontology

authors： Meciano Filho J,Carvalho VC,de Souza RR

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Each year, influenza and its complications account for 10,000-40,000 excess deaths in the United States. Over 80% of these deaths occur among the elderly. The Advisory Committee on Immunization Practices for the US Public Health Service and others recommend that all persons 65 years of age and older as well a...

journal_title：Gerontology

authors： Nichol KL,Margolis KL,Wouremna J,von Sternberg T

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Disturbance of vertical eye movement and ocular convergence is often observed in elderly people, but little is known about its frequency. OBJECTIVE:The purpose of this study was to investigate age-associated changes in vertical eye movement and convergence in healthy elderly people, using a digital video ca...

journal_title：Gerontology

authors： Oguro H,Okada K,Suyama N,Yamashita K,Yamaguchi S,Kobayashi S

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:It has been proposed that active engagement with life may protect against cognitive decline. However, existing instruments for measuring life engagement have covered limited domains. OBJECTIVE:To present a new instrument to measure engagement with life; the RIASEC Activities List draws on activities categor...

journal_title：Gerontology

authors： Parslow RA,Jorm AF,Christensen H,Mackinnon A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Despite declines in cognitive abilities, older adults often perform comparable to younger adults in everyday tasks [J Am Geriatr Soc 1999;47:172-183]. Older adults may compensate for cognitive declines by using more efficient strategies. People often improve their efficiency by switching from an algorithmic ...

journal_title：Gerontology

authors： Frank DJ,Jordano ML,Browne K,Touron DR

更新日期：2016-01-01 00:00:00

abstract：:Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because ...

journal_title：Gerontology

authors： Yu KR,Kang KS

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Early emergency readmissions is a common and important problem in the elderly patient. Identification of the risk factors for early emergency readmissions is needed to prevent this occurring. OBJECTIVE:The aim of this study was to study the risk factors for early emergency readmission in the elderly medical...

journal_title：Gerontology

authors： Chu LW,Pei CK

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The total cholesterol concentration decreases with age in older people. The reasons for this phenomenon are controversial. This study investigated the hypothesis that poor health status is a determinant of the inverse association between age and cholesterol in older persons. METHODS:Cross-sectional study of...

journal_title：Gerontology

authors： Volpato S,Zuliani G,Guralnik JM,Palmieri E,Fellin R

更新日期：2001-01-01 00:00:00

abstract：:Constant exposure to new and persisting antigens and the need to replace cellular attrition with newly built cells lead to profound remodeling of the immune system after the age of 50 years. The impact of the immunosenescence process varies amongst the different cellular subsets represented within the immune system. E...

journal_title：Gerontology

authors： Jagger A,Shimojima Y,Goronzy JJ,Weyand CM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Nerve growth factor (NGF), discovered because of its action on cells in the peripheral and the central nervous system, is now known to act also on immune cells in developing and adult subjects. Whether peripheral lymphocytes of aged subjects are responsive to this molecule is less clear. OBJECTIVE:Aim of ou...

journal_title：Gerontology

authors： Antonelli A,Bracci-Laudiero L,Aloe L

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Functional and physiological declines in advancing age may be significant limiting factors in reduced physical activity. Sarcopenia of aging, as a normative process or disease, cannot entirely explain reduced physical activity in the elderly. OBJECTIVE:The purpose of the study was to investigate the relatio...

journal_title：Gerontology

authors： Carmeli E,Reznick AZ,Coleman R,Carmeli V

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:As more people survive into old age, a greater number are becoming eligible for dialysis treatment for end-stage renal failure. In the UK the elderly have previously been excluded from treatment programmes, and continuing financial constraints are unlikely to improve this situation. There are few data on the...

journal_title：Gerontology

authors： Ahmed S,Addicott C,Qureshi M,Pendleton N,Clague JE,Horan MA

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:There are limited psychological data on the quality of life and activities of daily living among elderly Japanese who live alone. OBJECTIVE:The aim of this study was to examine the frequency of apathy and its correlation with activities of daily living and with subjective well-being in elderly people living...

journal_title：Gerontology

authors： Yamashita K,Iijima K,Kobayashi S

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Previous studies have shown links between cognitive impairment and hypertension as well as mortality. However, combined effects of these two conditions on mortality have not been fully explored. OBJECTIVE:To assess the combined effect of cognitive impairment and hypertension on all-cause mortality among the...

journal_title：Gerontology

authors： Gombojav B,Yi SW,Sull JW,Nam CM,Ohrr H

更新日期：2011-01-01 00:00:00

abstract：:Anion exchange (AE) proteins are present in human neurons in the brain. Immunohistochemical data indicate that their apparent expression level increases with age, and especially with degeneration in Alzheimer's disease-affected brain areas. The increase in immunoreactivity is probably caused by changes in AE structure...

journal_title：Gerontology

authors： Bosman GJ,Renkawek K,Van Workum FP,Bartholomeus IG,De Grip WJ

更新日期：1997-01-01 00:00:00

abstract：:Mental healthcare of elderly people is a common problem in advanced countries. Recently, high technology has developed robots for use not only in factories but also for our living environment. In particular, human-interactive robots for psychological enrichment, which provide services by interacting with humans while ...

journal_title：Gerontology

authors： Shibata T,Wada K

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to examine the effects of a multifactorial memory training program designed for normal older adults. The multifactorial program involved the training of three components that are critical to memory functioning: recoding operations, attentional functions and relaxation. Two controls groups...

journal_title：Gerontology

authors： Stigsdotter A,Bäckman L

更新日期：1989-01-01 00:00:00

abstract：:Aging researchers have long been interested in understanding individuals' subjective perceptions of their own memory functioning. Previous research has shown that subjective memory ratings are partly based on memory performance but also reflect the influence of other factors, such as depressive symptoms. The aim of th...

journal_title：Gerontology

authors： Hülür G,Hertzog C,Pearman AM,Gerstorf D

更新日期：2015-01-01 00:00:00