Abstract:
OBJECTIVE AND BACKGROUND:The aim of the present article is to discuss the potential of gene therapy for thymic hormones as a novel therapeutic strategy to treat dyshomeostatic states associated with athymia, as Di George syndrome, or hypothymic conditions like those associated with AIDS, chronic stress or aging. First we review the advantages of the athymic (nude) mouse as an animal model to implement experimental thymic hormone gene therapy strategies to restore endocrine thymic function. The aging rat, known to be markedly hypothymic, is also considered as an alternative model. METHODS AND EXPECTED RESULTS:The possibility of constructing adenoviral vectors harboring a synthetic gene for the thymic hormone thymulin is discussed. The adenoviral vector so constructed would then be injected intramuscularly in nude mice or senile rats. Transduced myocytes should then begin to act as an ectopic source of thymulin thus restoring circulating thymulin levels to normal youthful levels. CONCLUSION:We conclude that the implementation of thymulin gene therapy should provide novel biotechnological tools that will boost basic studies on the molecular biology of thymulin and would also allow an assessment of the potential of gene therapy to restore circulating thymulin levels in thymodeficient animal models.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Goya RG,Cónsole G,Hereñú C,Brown O,Rimoldi OJdoi
10.1159/000065258keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
325-8issue
5eissn
0304-324Xissn
1423-0003pii
65258journal_volume
48pub_type
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