Abstract:
:The rates of collagen fibril formation are, under otherwise identical conditions, a function of the age of the acid-soluble rat tail tendon collagen utilized. The rate is most rapid with young adult (165 day) collagen, which exhibits no induction period before collagen multimerization begins. In contrast, 21-day collagen exhibits both a 30% slower rate and an induction period. Collagens from older animals also have age-dependent fibril formation rates going from a maximum at 165 days to 80% of that for 1,100-day-old material. These age-related differences in collagen fibril formation kinetics appear to be related to the degree of cross-linking of the collagen involved.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Brooks C,Simons ERdoi
10.1159/000212248subject
Has Abstractpub_date
1978-01-01 00:00:00pages
161-8issue
3eissn
0304-324Xissn
1423-0003journal_volume
24pub_type
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