Influence of smoking and age on pharmacokinetics of beta-receptor blockers.

abstract：:The relation between carotid blood flow measured by Doppler spectrum analysis and brain atrophy on computed tomography (CT) was studied in 22 subjects with multiple lacunar cerebral infarctions. The subjects were divided into two groups, 7 patients with multi-infarct dementia (MID) (mean age 73 years) and 15 nondement...

journal_title：Gerontology

authors： Yamashita K,Kobayashi S,Yamaguchi S,Kitani M,Okada K,Fujihara S,Shimode K,Tsunematsu T

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Older adults are stereotypically considered to be risk averse compared to younger age groups, although meta-analyses on age and the influence of gain/loss framing on risky choices have not found empirical evidence for age differences in risk-taking. OBJECTIVE:The current study extends the investigation of a...

journal_title：Gerontology

authors： Best R,Freund AM

更新日期：2018-01-01 00:00:00

abstract：:(Na+-K+)-ATPase is an enzyme responsible for ionic homeostasis in excitable tissues. Thus, the activity of this enzyme is essential for the maintenance of optimal function of the cerebral cortex. Although abnormalities of cerebral oxidative metabolism have been described in aging, these abnormalities do not appear to ...

journal_title：Gerontology

authors： LaManna JC,Doull G,McCracken K,Harik SI

更新日期：1983-01-01 00:00:00

abstract：:As populations age globally, the health of older adults is looming larger on the agendas of public health bodies. In particular, the priority is to ensure that older adults remain healthy, independent, and engaged in their communities. In other words, ensuring that increasing life spans are matched by increasing "heal...

journal_title：Gerontology

authors： Doherty TM,Di Pasquale A,Michel JP,Del Giudice G

更新日期：2020-01-01 00:00:00

abstract：:Constant exposure to new and persisting antigens and the need to replace cellular attrition with newly built cells lead to profound remodeling of the immune system after the age of 50 years. The impact of the immunosenescence process varies amongst the different cellular subsets represented within the immune system. E...

journal_title：Gerontology

authors： Jagger A,Shimojima Y,Goronzy JJ,Weyand CM

更新日期：2014-01-01 00:00:00

abstract：:The experimental evidence is reviewed which bears on the theory that aging in mammalian cells may be related to a decline in the efficiency of normal DNA repair processes. Although the data are as yet fragmentary, they do suggest that there is an age-associated decline in the capacity of cells to perform at least cert...

journal_title：Gerontology

authors： Little JB

更新日期：1976-01-01 00:00:00

abstract：:In the present study, we examined the changes that occur with age in anti-idiotype-blocked, hapten-augmentable PFC in the mucosal-associated lymph nodes (MLN and BLN) and spleen of various strains of mice. 2-month-old 129/J, AKR/J, and C57L/J mice had a high percentage of hapten-augmentable PFC in their spleen, MLN, a...

journal_title：Gerontology

authors： Szewczuk MR,Wade AW

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Diabetes is common in elderly persons and is highly prevalent in Mexican Americans. Little is known about factors associated with the incidence of diabetes complications. OBJECTIVE:To examine the social, demographic and health factors associated with a 7-year incidence of diabetes complications among older ...

journal_title：Gerontology

authors： Kaushik VP,Al Snih S,Ray LA,Raji MA,Markides KS,Goodwin JS

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:There are limited psychological data on the quality of life and activities of daily living among elderly Japanese who live alone. OBJECTIVE:The aim of this study was to examine the frequency of apathy and its correlation with activities of daily living and with subjective well-being in elderly people living...

journal_title：Gerontology

authors： Yamashita K,Iijima K,Kobayashi S

更新日期：1999-09-01 00:00:00

abstract：:The biological rhythms of rectal temperature were documented in young (circadian variations) and elderly (circadian and seasonal variations) human subjects either in apparent good health or suffering from senile dementia of Alzheimer type (SDAT). All the subjects were synchronized. Data obtained showed a decrease of t...

journal_title：Gerontology

authors： Touitou Y,Reinberg A,Bogdan A,Auzéby A,Beck H,Touitou C

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:In Japan, vascular dementia (VD) has been responsible for the majority of all dementia cases in both epidemiological and neuropathological studies. Recently, however, several epidemiological investigations have shown that the rate of VD has decreased and senile dementia of the Alzheimer type (SDAT) is now th...

journal_title：Gerontology

authors： Seno H,Ishino H,Inagaki T,Iijima M,Kaku K,Inata T

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The chronic stress of providing care for a spouse suffering from Alzheimer's disease has been associated with an increased risk for coronary artery disease and overall mortality. Procoagulant changes are kindled by mental stress, and they are prospectively associated with atherothrombotic events. OBJECTIVE:...

journal_title：Gerontology

authors： von Kanel R,Dimsdale JE,Adler KA,Patterson TL,Mills PJ,Grant I

更新日期：2005-01-01 00:00:00

abstract：:Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...

journal_title：Gerontology

authors： Peng MT,Hsü HK

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Although white matter changes visible with MRI are generally considered to result from ischemia, it has become clear that these changes also appear in patients with Alzheimer's disease (AD). However, their significance in AD is unknown. OBJECTIVE:We evaluated the clinical significance of white matter change...

journal_title：Gerontology

authors： Kono I,Mori S,Nakajima K,Nakagawa M,Watanabe Y,Kizu O,Yamada K,Sakai Y

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Nerve growth factor (NGF), discovered because of its action on cells in the peripheral and the central nervous system, is now known to act also on immune cells in developing and adult subjects. Whether peripheral lymphocytes of aged subjects are responsive to this molecule is less clear. OBJECTIVE:Aim of ou...

journal_title：Gerontology

authors： Antonelli A,Bracci-Laudiero L,Aloe L

更新日期：2003-05-01 00:00:00

abstract：:The spectrum of aldimine cross-link bonds of skin collagen is dependent on the localization of the examined material. In correlation to this, there is no synchronous behaviour of cross-linkage in the aging process. The age-dependent decrease of HLNL and the increase of DHLNL in the collagen of tail tendon is only unsu...

journal_title：Gerontology

authors： Ruiz-Torres A

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:The leading causes of death and disability in the elderly are from cardiovascular and cerebrovascular diseases. The biological role of stem cells in the hematopoietic system has been well characterized and has led to the development of hematopoietic stem and progenitor cell (HSPC) transplantation for the tre...

journal_title：Gerontology

authors： Williams BA,Keating A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Functional and physiological declines in advancing age may be significant limiting factors in reduced physical activity. Sarcopenia of aging, as a normative process or disease, cannot entirely explain reduced physical activity in the elderly. OBJECTIVE:The purpose of the study was to investigate the relatio...

journal_title：Gerontology

authors： Carmeli E,Reznick AZ,Coleman R,Carmeli V

更新日期：2000-09-01 00:00:00

abstract：:Over the past decades, information about the characteristics of attractiveness has accumulated. We know about eight pillars of beauty, among them youthfulness, symmetry, hormone markers and body odor. But what is the biological function of these attractive signals? Is there one common function to be found in all eight...

journal_title：Gerontology

authors： Oberzaucher E,Grammer K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Future time perspective has been associated with subjective well-being, though depending on the line of research considered either an open-ended future time perspective or a limited future time perspective has been associated with high well-being. Most of this research however has conceptualized future time ...

journal_title：Gerontology

authors： Kozik P,Hoppmann CA,Gerstorf D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:compared with other vertebrate taxa, mammals possess a very limited capacity for appendage regeneration. The antlers of deer are an exception in that they are periodically lost and fully regenerated throughout the life of an individual. OBJECTIVE:in this paper we compare certain aspects of antler regenerati...

journal_title：Gerontology

authors： Kierdorf U,Kierdorf H

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial. It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome. OBJECTIVE:The purpose of this study was to determine whether age in...

journal_title：Gerontology

authors： Wakabayashi I

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Disturbance of vertical eye movement and ocular convergence is often observed in elderly people, but little is known about its frequency. OBJECTIVE:The purpose of this study was to investigate age-associated changes in vertical eye movement and convergence in healthy elderly people, using a digital video ca...

journal_title：Gerontology

authors： Oguro H,Okada K,Suyama N,Yamashita K,Yamaguchi S,Kobayashi S

更新日期：2004-05-01 00:00:00

abstract：:Induced tyrosine aminotransferase from adult and old rat liver was purified and its properties were studied. No differences could be detected for any physicochemical properties studied, i.e. specific activity, molecular weight, isoelectric point, thermostability, sensitivity to trypsin, Km for pyridoxal phosphate. Mor...

journal_title：Gerontology

authors： Szajnert MF,Schapira F

更新日期：1983-01-01 00:00:00

abstract：:The effects of long-term cigarette smoking on regional cerebral blood flow (rCBF) were studied in 67 normal male volunteers. All subjects were healthy volunteers without any past history of cerebral and pulmonary disease. rCBF decreased significantly with advancing age. Although there was no significant difference in ...

journal_title：Gerontology

authors： Yamashita K,Kobayashi S,Yamaguchi S,Kitani M,Tsunematsu T

更新日期：1988-01-01 00:00:00

abstract：:Walking and other physical activities were studied in a representative population sample of 619 70-year-old people in the city of Gothenburg, Sweden. Walking was the most common physical activity declared, and two thirds of those without an obvious disability walked 30 min or more every day. Subjects who took a daily ...

journal_title：Gerontology

authors： Frändin K,Grimby G,Mellström D,Svanborg A

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The common cause account suggests that there is a third factor causing aging effects in both sensory and cognitive functioning, hypothesized to be the integrity of the central nervous system [Lindenberger and Baltes; Psychol Aging 1994;9:339-355]. Importantly, the common cause account was developed based on ...

journal_title：Gerontology

authors： Sternäng O,Jonsson B,Wahlin A,Nyberg L,Nilsson LG

更新日期：2010-01-01 00:00:00

abstract：:Empirical evidence for the conjecture that brain weight of mammals is a better predictor of life span than is body weight, is reexamined and evaluated in this paper. The original evidence was that for 63 mammalian species, log brain weight explained 79% of the log life span variance, whereas log body weight explained ...

journal_title：Gerontology

authors： Economos AC

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:As more people survive into old age, a greater number are becoming eligible for dialysis treatment for end-stage renal failure. In the UK the elderly have previously been excluded from treatment programmes, and continuing financial constraints are unlikely to improve this situation. There are few data on the...

journal_title：Gerontology

authors： Ahmed S,Addicott C,Qureshi M,Pendleton N,Clague JE,Horan MA

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:There is a need for simple clinical tools that can objectively assess the fall risk in people with dementia. Wearable sensors seem to have the potential for fall prediction; however, there has been limited work performed in this important area. OBJECTIVE:To explore the validity of sensor-derived physical ac...

journal_title：Gerontology

authors： Schwenk M,Hauer K,Zieschang T,Englert S,Mohler J,Najafi B

更新日期：2014-01-01 00:00:00