Regulatory T cells and the immune aging process: a mini-review.

abstract：:Dietary intake, sunlight exposure and 25-hydroxy-vitamin D levels were estimated in 62 patients admitted to a geriatric assessment unit. There was a significant correlation between vitamin D intake and 25-hydroxy-vitamin D levels but none between sunlight exposure and these. This suggests that in old age dietary defic...

journal_title：Gerontology

authors： Nayal AS,MacLennan WJ,Hamilton JC,Rose P,Kong M

更新日期：1978-01-01 00:00:00

abstract：:In this paper we asked whether the increased production of two proinflammatory cytokines-tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL6) in the absence of the inflammatory stimulus, a phenomenon frequently occurring in the elderly, may contribute to the decrease of natural killer (NK) cytotoxic activit...

journal_title：Gerontology

authors： Myśliwska J,Bryl E,Zorena K,Balon J,Foerster J,Myśliwski A

更新日期：1997-01-01 00:00:00

abstract：:Caloric restriction (CR), has been shown to extend average and maximum lifespan in rodents and other animals as well as to delay a wide variety of manifestations of aging. The purpose of this study was to further elucidate the relationship between lipofuscin (LF) accumulation and the aging process by examining the eff...

journal_title：Gerontology

authors： Moore WA,Davey VA,Weindruch R,Walford R,Ivy GO

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:While many studies investigate the factors that influence the institutionalisation of older persons, only a few consider one of its most important predictors, namely, the perceived need for institutionalisation. Also referred to as 'desire for institutionalisation', it has mainly been investigated for inform...

journal_title：Gerontology

authors： Dubois MF,Dubuc N,Raîche M,Caron CD,Hébert R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP), a nonspecific marker of the inflammatory status, is associated with cardiovascular disease risk factors and may be an important feature of the metabolic syndrome (MSX) in middle-aged subjects. OBJECTIVES:We assessed the relationship of CRP levels to specific components of MSX and o...

journal_title：Gerontology

authors： Dupuy AM,Jaussent I,Lacroux A,Durant R,Cristol JP,Delcourt C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Research on the relationship between vestibular function and falls in older people is sparse. The perception of the postural vertical (PPV) provides an indicator measure of vestibular (otolith) function in the absence of visual input and diminished somatosensory feedback. OBJECTIVE:This study examined wheth...

journal_title：Gerontology

authors： Menant JC,St George RJ,Fitzpatrick RC,Lord SR

更新日期：2012-01-01 00:00:00

abstract：:The life span of Drosophila melanogaster was reduced when copper compounds were fed at concentrations of 1 X 10(-3) M or greater. Feeding lower concentrations of copper compounds failed to significantly change life span. A combination of copper gluconate and gluconic acid increased the adult life span by 21.6%. We con...

journal_title：Gerontology

authors： Massie HR,Williams TR,Aiello VR

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Malnutrition is a widespread but largely unrecognized problem in aged patients, more so as it is a contributing factor to the increased morbidity and mortality in this age group. Since direct measurements of body composition are not possible in a large number of patients, good anthropometric reference data a...

journal_title：Gerontology

authors： Bonnefoy M,Jauffret M,Kostka T,Jusot JF

更新日期：2002-05-01 00:00:00

abstract：:The effect of age on the compositional analysis of human Descemet's membrane was examined. Membranes were obtained from human corneas ranging from 0.5 to 95 years and purified by sodium dodecyl sulfate (SDS) extraction. Substantial age-related changes were obtained in the amino acid compositions of the SDS-insoluble b...

journal_title：Gerontology

authors： Freeman IL,Vergnes JP,Brown SI

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Functional and physiological declines in advancing age may be significant limiting factors in reduced physical activity. Sarcopenia of aging, as a normative process or disease, cannot entirely explain reduced physical activity in the elderly. OBJECTIVE:The purpose of the study was to investigate the relatio...

journal_title：Gerontology

authors： Carmeli E,Reznick AZ,Coleman R,Carmeli V

更新日期：2000-09-01 00:00:00

abstract：:The conditioned avoidance response and the cerebral levels of dopamine and noradrenaline have been studied in control rats and in rats submitted to a hypobaric hypoxia. A protection against the effects of hypoxia was induced by both dihydroergocornine (20 microgram/kg) and dihydroergocryptine (100 microgram/kg), and t...

journal_title：Gerontology

authors： Boismare F,Le Poncin M,Lefrançois J

更新日期：1978-01-01 00:00:00

abstract：:The concentrations of noradrenaline and adrenaline were studied in specimens of the posterior tibial artery obtained from 18 subjects at postmortem examination. The mean noradrenaline concentration was 167 ng/g artery (range 17-449 ng/g) and the mean adrenaline concentration was 5 ng/g (range 0--21 ng/g). There was no...

journal_title：Gerontology

authors： Neubauer B,Christensen NJ

更新日期：1978-01-01 00:00:00

abstract：:The characteristics of long-stay patients (defined as those staying more than 6 months) have been studied in a prospective series of 2,405 admissions. 5.6% become long-stay patients and they were more likely to be women, to be readmissions, to have been admitted from an old people's home, to have been non-emergency ad...

journal_title：Gerontology

authors： Hodkinson I,Hodkinson HM

更新日期：1981-01-01 00:00:00

abstract：:Mental healthcare of elderly people is a common problem in advanced countries. Recently, high technology has developed robots for use not only in factories but also for our living environment. In particular, human-interactive robots for psychological enrichment, which provide services by interacting with humans while ...

journal_title：Gerontology

authors： Shibata T,Wada K

更新日期：2011-01-01 00:00:00

abstract：:Some authors have hypothesised that life expectancy at birth could reach 100 years in developed countries in the next decades. Using recent data for French women, it is shown that life expectancy changes from 1993 to 2016 are mainly linked to mortality rates of oldest women. In recent years, it happened that life expe...

journal_title：Gerontology

authors： Le Bourg E

更新日期：2019-01-01 00:00:00

abstract：:Morphometric measurements have been carried out on the human myenteric esophageal neurons at the ages of 20-40 and more than 70 years. The number of neurons decreases after 70 years of age, which is accompanied by an increase in the sizes of the neurons. In percentage terms the decrease in the number of neurons in the...

journal_title：Gerontology

authors： Meciano Filho J,Carvalho VC,de Souza RR

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:compared with other vertebrate taxa, mammals possess a very limited capacity for appendage regeneration. The antlers of deer are an exception in that they are periodically lost and fully regenerated throughout the life of an individual. OBJECTIVE:in this paper we compare certain aspects of antler regenerati...

journal_title：Gerontology

authors： Kierdorf U,Kierdorf H

更新日期：2011-01-01 00:00:00

abstract：:In the present study, we examined the changes that occur with age in anti-idiotype-blocked, hapten-augmentable PFC in the mucosal-associated lymph nodes (MLN and BLN) and spleen of various strains of mice. 2-month-old 129/J, AKR/J, and C57L/J mice had a high percentage of hapten-augmentable PFC in their spleen, MLN, a...

journal_title：Gerontology

authors： Szewczuk MR,Wade AW

更新日期：1985-01-01 00:00:00

abstract：:Neurofilament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer's disease. The abnormally proliferated neurofilament was characterized by immunostaining and electron microscopy. The intracytoplasmic neurofilament ...

journal_title：Gerontology

authors： Takeda M,Nishimura T,Kudo T,Tanimukai S,Gotow T,Tanabe H,Miki T,Nakamura Y,Niigawa H,Morita H

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Although white matter changes visible with MRI are generally considered to result from ischemia, it has become clear that these changes also appear in patients with Alzheimer's disease (AD). However, their significance in AD is unknown. OBJECTIVE:We evaluated the clinical significance of white matter change...

journal_title：Gerontology

authors： Kono I,Mori S,Nakajima K,Nakagawa M,Watanabe Y,Kizu O,Yamada K,Sakai Y

更新日期：2004-07-01 00:00:00

abstract：:Still's disease is very rare in elderly patients. We report a case of Still's disease in an elderly patient that had an atypical initial presentation. A 76-year-old woman developed unexplained chronic anemia and thrombocytosis. Three years later she had acute onset of high fever, arthritis, maculopapular rash, pleurit...

journal_title：Gerontology

authors： Vilá LM,Molina MJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Cardiac surgery is widely believed to be an excessively high-risk intervention for very elderly patients with coronary artery or valvular disease. However, as life expectancy and the prospect of sustained quality of life into older age increase, this assumption should be challenged so that surgery is not den...

journal_title：Gerontology

authors： Guilfoyle MR,Drain AJ,Khan A,Ferguson J,Large SR,Nashef SA

更新日期：2010-01-01 00:00:00

abstract：:Typically, subjective memory assessments (be it in form of single items or questionnaires) in old age only weakly correlate with the performance in objective memory tests at cross-section. It thus appears as if individual differences in subjective memory assessments hardly reflect individual differences in memory in o...

journal_title：Gerontology

authors： Zimprich D,Kurtz T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:A large proportion of falls in older people are caused by slipping. Previous occupational safety research suggests that inadequate footwear may contribute to slipping accidents; however, no studies have assessed the slip resistance of casual footwear. OBJECTIVE:To evaluate the slip resistance of different t...

journal_title：Gerontology

authors： Menz HB,Lord ST,McIntosh AS

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Dual-task-based assessment tests failed to establish a dependable relationship between dual-task-related gait changes and the risk of falls in the elderly. OBJECTIVE:The aim of this study was to examine whether changes in gait while counting backward could be associated with the occurrence of a first fall a...

journal_title：Gerontology

authors： Beauchet O,Allali G,Annweiler C,Berrut G,Maarouf N,Herrmann FR,Dubost V

更新日期：2008-01-01 00:00:00

abstract：:We studied the correlation between the in vitro lymphocyte proliferative response and some early parameters of lymphocyte activation in aged people. While a consistent number of elderly subjects showed significantly decreased proliferative responses to mitogen stimulation, interleukin-1 (IL-1) production and IL-2 rece...

journal_title：Gerontology

authors： Amadori A,Zanovello P,Cozzi E,Ciminale V,Borghesan F,Fagiolo U,Crepaldi G

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease ...

journal_title：Gerontology

authors： Barnett BP,Handa JT

更新日期：2013-01-01 00:00:00

abstract：:Aging researchers have long been interested in understanding individuals' subjective perceptions of their own memory functioning. Previous research has shown that subjective memory ratings are partly based on memory performance but also reflect the influence of other factors, such as depressive symptoms. The aim of th...

journal_title：Gerontology

authors： Hülür G,Hertzog C,Pearman AM,Gerstorf D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:As more people survive into old age, a greater number are becoming eligible for dialysis treatment for end-stage renal failure. In the UK the elderly have previously been excluded from treatment programmes, and continuing financial constraints are unlikely to improve this situation. There are few data on the...

journal_title：Gerontology

authors： Ahmed S,Addicott C,Qureshi M,Pendleton N,Clague JE,Horan MA

更新日期：1999-05-01 00:00:00

abstract：:We studied the effects of factors associated with vascular injury on the production of endothelin-1 (ET-1) in cultured porcine aortic endothelial cells. ET-1 mRNA expression and peptide production in endothelial cells were increased by thrombin, transforming growth factor beta 1 (TGF beta 1), interleukin-1 (IL-1) and ...

journal_title：Gerontology

authors： Maemura K,Kurihara H,Morita T,Oh-hashi Y,Yazaki Y

更新日期：1992-01-01 00:00:00