Study of some early immunological parameters in aging humans.

Abstract:

:We studied the correlation between the in vitro lymphocyte proliferative response and some early parameters of lymphocyte activation in aged people. While a consistent number of elderly subjects showed significantly decreased proliferative responses to mitogen stimulation, interleukin-1 (IL-1) production and IL-2 receptor/DR antigen expression were comparable to those of young controls. The reduction in IL-2 production observed in some aged donors did not correlate with the decreased proliferative activity in response to mitogen. Moreover, addition to the cultures of recombinant IL-2 was not capable of restoring the proliferative response to normal levels. These data on the whole seem to argue against a primary involvement in age-associated lymphocyte hyporesponsiveness of an alteration in the early phases of lymphocyte activation engaging the complex lymphokine/receptor network.

journal_name

Gerontology

journal_title

Gerontology

authors

Amadori A,Zanovello P,Cozzi E,Ciminale V,Borghesan F,Fagiolo U,Crepaldi G

doi

10.1159/000212966

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

277-83

issue

5-6

eissn

0304-324X

issn

1423-0003

journal_volume

34

pub_type

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