Abstract:
:We studied the correlation between the in vitro lymphocyte proliferative response and some early parameters of lymphocyte activation in aged people. While a consistent number of elderly subjects showed significantly decreased proliferative responses to mitogen stimulation, interleukin-1 (IL-1) production and IL-2 receptor/DR antigen expression were comparable to those of young controls. The reduction in IL-2 production observed in some aged donors did not correlate with the decreased proliferative activity in response to mitogen. Moreover, addition to the cultures of recombinant IL-2 was not capable of restoring the proliferative response to normal levels. These data on the whole seem to argue against a primary involvement in age-associated lymphocyte hyporesponsiveness of an alteration in the early phases of lymphocyte activation engaging the complex lymphokine/receptor network.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Amadori A,Zanovello P,Cozzi E,Ciminale V,Borghesan F,Fagiolo U,Crepaldi Gdoi
10.1159/000212966subject
Has Abstractpub_date
1988-01-01 00:00:00pages
277-83issue
5-6eissn
0304-324Xissn
1423-0003journal_volume
34pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract::Various parameters of copulatory behavior were examined in intact and castrated testosterone-(T-)treated male rats of various ages ranging from 3 to 27 months. Serum T levels were controlled by subcutaneous implantation of different sizes of T-filled Silastic capsules at the time of castration. In intact male rats, sc...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212760
更新日期:1986-01-01 00:00:00
abstract::The conditioned avoidance response and the cerebral levels of dopamine and noradrenaline have been studied in control rats and in rats submitted to a hypobaric hypoxia. A protection against the effects of hypoxia was induced by both dihydroergocornine (20 microgram/kg) and dihydroergocryptine (100 microgram/kg), and t...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212292
更新日期:1978-01-01 00:00:00
abstract::In the present study, we examined the changes that occur with age in anti-idiotype-blocked, hapten-augmentable PFC in the mucosal-associated lymph nodes (MLN and BLN) and spleen of various strains of mice. 2-month-old 129/J, AKR/J, and C57L/J mice had a high percentage of hapten-augmentable PFC in their spleen, MLN, a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212708
更新日期:1985-01-01 00:00:00
abstract::Recently, Granacher et al. (2010) proposed an intergenerational approach to promoting balance and strength for fall prevention in children and elderly subjects together. Although this sounds like a stimulating idea, its effectiveness for fall prevention in both groups has yet to be demonstrated. Undoubtedly, fall prev...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000322930
更新日期:2011-01-01 00:00:00
abstract::In the absence of a single marker that reliably reflects biological aging, or even an exact definition of biological age, compound aging scores that combine multiple aging biomarkers into a single composite aging score can quantitatively reflect the age-related changes over time. If aging is viewed as the broad accumu...
journal_title:Gerontology
pub_type: 评论,杂志文章
doi:10.1159/000433466
更新日期:2015-01-01 00:00:00
abstract::100 consecutive endoscopies in elderly patients referred with symptoms after previous gastric surgery are reviewed. 57% showed positive findings, and the procedure was found particularly useful in making definitive diagnoses in patients presenting with dyspepsia and upper gastro-intestinal bleeding. The incidence of g...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212699
更新日期:1985-01-01 00:00:00
abstract::One of the problems associated with using random-source dogs to study in vivo vascular responses is their unknown background. Since aging is known to influence vascular responses, unknown variations in age could influence experimental results. The vast majority of aging studies examine arteries in vitro. This study wa...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213318
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Future time perspective has been associated with subjective well-being, though depending on the line of research considered either an open-ended future time perspective or a limited future time perspective has been associated with high well-being. Most of this research however has conceptualized future time ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000368716
更新日期:2015-01-01 00:00:00
abstract::A brief review is given of the use of fluoride, mithramycin, glucagon, actinomycin D, calcitonins and diphosphonates for treatment of Paget's disease of bone. The decision regarding treatment, effectiveness of the drugs, the incidence of side effects and assessment of clinical, biochemical, histological, radiological ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212334
更新日期:1979-01-01 00:00:00
abstract::The concentration of malonaldehyde (MDA) was measured in human erythrocytes obtained from subjects suffering from senile dementia of the Alzheimer type (SDAT), non-demented elderly subjects, and from young controls by two methods: high-performance liquid chromatography (HPLC) and the thiobarbituric acid (TBA) test. Th...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213853
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:The identification of modifiable health span-promoting factors is a public health priority. OBJECTIVE:To explore the socio-environmental, lifestyle, behavioural, and psychological determinants of a clinical phenotypic measure of biological ageing in the Singapore Longitudinal Ageing Study (SLAS) cohort. ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000511211
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:A quantitative study of dermal and arterial elastic fibers as a function of age was carried out by computerized image analysis. OBJECTIVE:We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal artery in elderly subjects...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022035
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated that measures of lower quality of care and associated adverse health effects are more prevalent in for-profit nursing homes compared to not-for-profit facilities. However, these studies omit persons who receive care in the community setting, and exclusively focus on isolated clinica...
journal_title:Gerontology
pub_type: 杂志文章,多中心研究
doi:10.1159/000492029
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Old age has traditionally been considered to begin at age 65. The improving health and functional status observed among older people may necessitate reevaluation of this cut-off point. OBJECTIVE:To present the changing prevalence of common geriatric syndromes, functional parameters, common disease status an...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000335238
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Although cross-sectional studies have demonstrated associations between visual contrast sensitivity and cognitive test performance, it remains unclear whether peripheral visual or perceptual factors explain the association. OBJECTIVE:We aimed at determining whether reducing static contrast of the study stim...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000090958
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:One of the earliest and most persistent inquiries in developmental psychology is that of the relative contributions of nature and nurture to human ontogeny. One way of studying this distinction is by doing cross-cultural studies, in which culture provides a powerful way to operationalize the influence of nur...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000094610
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:During development and aging, as well as under hypoxia, many cells can adapt to a stressful environment, while others are damaged and die by apoptosis. In particular, intermittent hypoxia, i.e., hypoxia followed by reoxygenation, determines different responses in young and adult myocardia. OBJECTIVE:In the ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000089821
更新日期:2006-01-01 00:00:00
abstract::Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because ...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000353857
更新日期:2013-01-01 00:00:00
abstract::The biological rhythms of rectal temperature were documented in young (circadian variations) and elderly (circadian and seasonal variations) human subjects either in apparent good health or suffering from senile dementia of Alzheimer type (SDAT). All the subjects were synchronized. Data obtained showed a decrease of t...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212774
更新日期:1986-01-01 00:00:00
abstract::The age-related accumulation of lipopigments was determined in the adrenergic and nonadrenergic peripheral neurons of the rat using a microspectrofluorometric method and electron microscopy, 3-, 12- and 30-month-old rats were used. The rate of lipopigment accumulation was greater in nonadrenergic than adrenergic neuro...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212808
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The rate of lipogenesis and gene expression of lipogenic enzymes in white adipose tissue (WAT) of rats decreases with age. Previously, we showed the inverse relationship between serum leptin concentration and lipogenic enzymes activities in WAT of ageing rats. Based on those results, we postulated that lepti...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000187430
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The chronic stress of providing care for a spouse suffering from Alzheimer's disease has been associated with an increased risk for coronary artery disease and overall mortality. Procoagulant changes are kindled by mental stress, and they are prospectively associated with atherothrombotic events. OBJECTIVE:...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000081428
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of peroxide-containing strip-based tooth whitening among subjects with medication-induced hyposalivation. METHODS:Eligibility for this tooth whitening study was limited to dentate adults takin...
journal_title:Gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000235815
更新日期:2009-01-01 00:00:00
abstract::A prospective study of post-operative morbidity in 258 elderly general surgical patients is reported. In 35% of patients no post-operative complications developed. Respiratory, wound and cardiac complications were the leading types of post-operative morbidity encountered, occurring in 39.5, 16.3, and 12.4% of patients...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213125
更新日期:1983-01-01 00:00:00
abstract::Cell surface of chick fibroblasts were labelled by a short treatment with 125I in presence of lactoperoxidase. A glycoprotein (220,000 molec. wt) was iodinated and was present in a more exposed position or in greater amounts at the surface of old phase III cells compared to young phase II cells. The findings extend ou...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212149
更新日期:1976-01-01 00:00:00
abstract::The 'use it or lose it' hypothesis of cognitive aging predicts that engagement in intellectual, social, and physical activities offers protective benefits from age-related cognitive decline and lowers dementia risk. Although this hypothesis has not yet been supported conclusively, there is some empirical evidence in f...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000264918
更新日期:2010-01-01 00:00:00
abstract::Neurofilament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer's disease. The abnormally proliferated neurofilament was characterized by immunostaining and electron microscopy. The intracytoplasmic neurofilament ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213295
更新日期:1991-01-01 00:00:00
abstract::The vascular system of 30 old asymptomatic patients (average age 62.5 years) was studied by reflection plethysmography. The plethysmogram (PTG) was recorded from the forefinger of the left hand at rest, during two postural tests (+45 degrees arm-up and -45 degrees arm-down), after physical work, and during the infusio...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212317
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Historically, older adults have been disproportionately affected by disasters. In particular, homebound adults are especially at risk. As one facet of bolstering community resilience, home health agencies have been tasked with improving their patients' disaster preparedness. However, home health practitioner...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000494971
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Constipation and lower urinary tract symptoms (LUTS) very frequently occur in the elderly, and several reports have suggested that dysfunction in either one of these systems may affect the other. Most studies correlating rectal and bladder dysfunction, however, have been carried out in children or young wome...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000052776
更新日期:2001-03-01 00:00:00