Disorders in peripheral arterial system in asymptomatic elderly: plethysmographic semiology at rest, during postural, effort and pharmacological tests.

abstract：:Because the body composition effects of growth hormone and insulin-like growth factor-I (IGF-I) are opposite to those of advancing age, it has been hypothesized that the decreased activity of the growth hormone-IGF-I axis is partly responsible for the loss of bone and muscle mass that characterizes normal human aging....

journal_title：Gerontology

authors： Boonen S,Lesaffre E,Aerssens J,Pelemans W,Dequeker J,Bouillon R

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:The prevalence of aortic stenosis is nearly 20% in octogenarians. Aortic valve replacement (AVR) is the optimal therapy choice, yet many symptomatic patients are denied this beneficent technology. Whether mechanical or bioprosthetic, aortic valves are not a scarce resource and their safety, effectiveness and...

journal_title：Gerontology

authors： Bramstedt KA

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Irrelevant unexpected stimuli elicit various types of inhibitory processes modulated by ongoing activity. An index of the inhibitory processes, namely the N2b and P3a event-related potentials (ERP), shows marked age-related differences. OBJECTIVE:In this experiment, we attempted to separate the effects of i...

journal_title：Gerontology

authors： Pató L,Czigler I

更新日期：2011-01-01 00:00:00

abstract：:The characteristics of long-stay patients (defined as those staying more than 6 months) have been studied in a prospective series of 2,405 admissions. 5.6% become long-stay patients and they were more likely to be women, to be readmissions, to have been admitted from an old people's home, to have been non-emergency ad...

journal_title：Gerontology

authors： Hodkinson I,Hodkinson HM

更新日期：1981-01-01 00:00:00

abstract：:Protein malnutrition is associated with a decreased febrile and acute phase response to infection and increased mortality. To elucidate a cause for this poor response, we assessed the effect of chronic protein malnutrition on monocyte production of the pyrogens interleukin-1 (IL-1) and tumor necrosis factor (TNF). Thi...

journal_title：Gerontology

authors： Bradley SF,Vibhagool A,Fabrick S,Terpenning MS,Kauffman CA

更新日期：1990-01-01 00:00:00

abstract：:Alteration in lipid peroxidation products such as lipid peroxides, lipid hydroperoxides were studied in different regions of CNS of ageing rats (13, 26, 52, 78 and 104 weeks). The levels of lipid peroxide and lipid hydroperoxide were increased in various regions of brain and spinal cord. However, the activity of super...

journal_title：Gerontology

authors： Gupta A,Hasan M,Chander R,Kapoor NK

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:As more people survive into old age, a greater number are becoming eligible for dialysis treatment for end-stage renal failure. In the UK the elderly have previously been excluded from treatment programmes, and continuing financial constraints are unlikely to improve this situation. There are few data on the...

journal_title：Gerontology

authors： Ahmed S,Addicott C,Qureshi M,Pendleton N,Clague JE,Horan MA

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The results of the very few histochemical studies that have been performed so far on the lectin-binding profile of normal human epidermis are mostly controversial; thus, the carbohydrate residue composition of the cell surface in the latter still remains in dispute and the possible alterations in the epiderm...

journal_title：Gerontology

authors： Georgiou S,Pasmatzi E,Monastirli A,Sakkis T,Alachioti S,Tsambaos D

更新日期：2005-05-01 00:00:00

abstract：:The specific activities of NAD-linked isocitric dehydrogenase were determined in hypothalamus, cerebellum, pons and medulla, striatum, midbrain, and cerebral cortex (which included the hippocampus) of the female Wistar rat. In ageing the specific activities of this enzyme were decreased in all regions. Chronic treatme...

journal_title：Gerontology

authors： Lai JC,Leung TK,Lim L

更新日期：1982-01-01 00:00:00

abstract：:Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because ...

journal_title：Gerontology

authors： Yu KR,Kang KS

更新日期：2013-01-01 00:00:00

abstract：:During a winter epidemic of A/H1N1 influenza virus, we evaluated the protection conferred by vaccination of 285 residents of a nursing home. Fifteen of 204 members of the nursing staff were also vaccinated. Serological determinations were performed before and after vaccination using radial hemolysis (RH) and neuramini...

journal_title：Gerontology

authors： Odelin MF,Pozzetto B,Aymard M,Defayolle M,Jolly-Million J

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The rate of lipogenesis and gene expression of lipogenic enzymes in white adipose tissue (WAT) of rats decreases with age. Previously, we showed the inverse relationship between serum leptin concentration and lipogenic enzymes activities in WAT of ageing rats. Based on those results, we postulated that lepti...

journal_title：Gerontology

authors： Nogalska A,Stelmanska E,Sledzinski T,Swierczynski J

更新日期：2009-01-01 00:00:00

abstract：:The activity of ceruloplasmin (CP) increased 3-fold in rat blood between 1 week and 20 months of age, but the difference in CP activity of adult and old rats was only 14%, which still is statistically significant (p less than 0.01). The increase in NaCl and KCl concentrations in vitro resulted in the same exponential ...

journal_title：Gerontology

authors： Semsei I

更新日期：1991-01-01 00:00:00

abstract：:The pharmacokinetics of indomethacin (Indo) was studied in 10 healthy elderly male volunteers (age 67-81 years) following the oral administration of a single 75-mg dose of a sustained release form of Indo. The total and free plasma and erythrocyte concentrations of Indo were determined by a specific high-pressure liqu...

journal_title：Gerontology

authors： Bruguerolle B,Barbeau G,Bélanger PM,Labrecque G

更新日期：1986-01-01 00:00:00

abstract：:The life span of Drosophila melanogaster was reduced when copper compounds were fed at concentrations of 1 X 10(-3) M or greater. Feeding lower concentrations of copper compounds failed to significantly change life span. A combination of copper gluconate and gluconic acid increased the adult life span by 21.6%. We con...

journal_title：Gerontology

authors： Massie HR,Williams TR,Aiello VR

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Future time perspective has been associated with subjective well-being, though depending on the line of research considered either an open-ended future time perspective or a limited future time perspective has been associated with high well-being. Most of this research however has conceptualized future time ...

journal_title：Gerontology

authors： Kozik P,Hoppmann CA,Gerstorf D

更新日期：2015-01-01 00:00:00

abstract：:Two kinds of evidence, taken in conjunction, indicate that Orgel's theory is inapplicable to a wide range of disorders of senescence in man. The age dependence and the anatomical distribution of the lesions of such disorders imply a Burnet type 'forbidden clone' theory of ageing. We describe the difficulty of establis...

journal_title：Gerontology

authors： Burch PR,Jackson D

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:It is known that growth factors play a role in ageing and atherogenesis, and insulin develops mitogenic activity in vitro. OBJECTIVES:This study focuses on the pathway by which insulin induces proliferation and mobility in vascular smooth muscle cells (SMCs) compared with that of insulin-like growth factor-...

journal_title：Gerontology

authors： Ruiz-Torres A,Lozano R,Melón J,Carraro R

更新日期：2005-07-01 00:00:00

abstract：:Aging researchers have long been interested in understanding individuals' subjective perceptions of their own memory functioning. Previous research has shown that subjective memory ratings are partly based on memory performance but also reflect the influence of other factors, such as depressive symptoms. The aim of th...

journal_title：Gerontology

authors： Hülür G,Hertzog C,Pearman AM,Gerstorf D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Although a relationship between diet and mortality is well recognized, there is little information on the extent to which different food sources contribute to survival in elderly people. OBJECTIVE:To examine the effect of individual food groups on mortality in institutionalized elderly people from Asturias ...

journal_title：Gerontology

authors： González S,Huerta JM,Fernández S,Patterson AM,Lasheras C

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Declines in physical fitness can notably affect healthy aging of older adults. Multimodal exercise training regimen such as mind-body interventions (MBIs) has been reported to mitigate these aging-related declines of physical function. This meta-analytical review aimed at pooling the effects of MBIs on phy...

journal_title：Gerontology

authors： Ebner SA,Meikis L,Morat M,Held S,Morat T,Donath L

更新日期：2021-01-27 00:00:00

abstract：:The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased ...

journal_title：Gerontology

authors： Zs-Nagy I,Pieri C,Giuli C,Del Moro M

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The chronological age is clearly the strongest risk factor for fractures or death. Age as a concept can be described exactly as chronological age. Age in relative terms can be described as biological age. OBJECTIVE:We postulated that, even without taking into account known or unknown comorbidity, an immedia...

journal_title：Gerontology

authors： Gerdhem P,Ringsberg K,Akesson K,Obrant KJ

更新日期：2004-09-01 00:00:00

abstract：:Caloric restriction (CR), has been shown to extend average and maximum lifespan in rodents and other animals as well as to delay a wide variety of manifestations of aging. The purpose of this study was to further elucidate the relationship between lipofuscin (LF) accumulation and the aging process by examining the eff...

journal_title：Gerontology

authors： Moore WA,Davey VA,Weindruch R,Walford R,Ivy GO

更新日期：1995-01-01 00:00:00

abstract：:The article discusses some aspects demonstrating that a decrease in acetylcholine synthesis in senile dementia of the Alzheimer type (SDAT) is a consequence of the strong decline in glucose turnover in the brain. This becomes obvious by the fact that acetylcoenzyme A, the key substrate of acetylcholine synthesis, is e...

journal_title：Gerontology

authors： Meier-Ruge W,Bertoni-Freddari C,Iwangoff P

更新日期：1994-01-01 00:00:00

abstract：:The concentration of malonaldehyde (MDA) was measured in human erythrocytes obtained from subjects suffering from senile dementia of the Alzheimer type (SDAT), non-demented elderly subjects, and from young controls by two methods: high-performance liquid chromatography (HPLC) and the thiobarbituric acid (TBA) test. Th...

journal_title：Gerontology

authors： Bermejo P,Gómez-Serranillos P,Santos J,Pastor E,Gil P,Martín-Aragón S

更新日期：1997-01-01 00:00:00

abstract：:The influence of age and smoking on pharmacokinetics of pindolol and propranolol was investigated. Although there was a statistically significant difference in certain pharmacokinetic parameters (maximum plasma concentration, area under the curve, elimination constant and elimination half-life) between elderly patient...

journal_title：Gerontology

authors： Hitzenberger G,Fitscha P,Beveridge T,Nüesch E,Pacha W

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Previous extensive clinical studies, using angiography or ultrasound, investigated the influence of alimentary, medicamentous and other antiatherosclerotic measures on the degree of atherosclerosis. The following signs of regression were found: clinical improvement, changes in tonus of vascular walls, format...

journal_title：Gerontology

authors： Kunz J

更新日期：2002-09-01 00:00:00

abstract：:Cell surface of chick fibroblasts were labelled by a short treatment with 125I in presence of lactoperoxidase. A glycoprotein (220,000 molec. wt) was iodinated and was present in a more exposed position or in greater amounts at the surface of old phase III cells compared to young phase II cells. The findings extend ou...

journal_title：Gerontology

authors： Courtois Y,Hughes RC

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Paratonia is a distinctive form of hypertonia, causing loss of functional mobility in early stages of dementia to severe high muscle tone and pain in the late stages. For assessing and evaluating therapeutic interventions, objective instruments are required. OBJECTIVE:Determine the psychometric properties o...

journal_title：Gerontology

authors： Drenth H,Zuidema SU,Krijnen WP,Bautmans I,van der Schans C,Hobbelen H

更新日期：2018-01-01 00:00:00