Molecular mechanisms of ageing. A critique.

abstract：:Hydrogen breath testing (HBT) is frequently used as an alternative to small bowel aspiration in the diagnosis of small intestinal bacterial overgrowth (SIBO). The role of the glucose HBT was assessed in 30 elderly patients. A positive HBT was recorded in 15 of 20 SIBO cases and 7 of 10 culture negatives (sensitivity 7...

journal_title：Gerontology

authors： Mac Mahon M,Gibbons N,Mullins E,O'Moore RR,Keane CT,Walsh JB,Coakley D

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Moderate physical exercise, dietary restriction as well as enriched environment in separate studies have been reported to delay some of the adverse effects of aging on brain function, parallel to an increase in brain-derived neurotrophic factor (BDNF). In order to elucidate these influences in a com...

journal_title：Gerontology

authors： Strasser A,Skalicky M,Hansalik M,Viidik A

更新日期：2006-01-01 00:00:00

abstract：:In this paper we asked whether the increased production of two proinflammatory cytokines-tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL6) in the absence of the inflammatory stimulus, a phenomenon frequently occurring in the elderly, may contribute to the decrease of natural killer (NK) cytotoxic activit...

journal_title：Gerontology

authors： Myśliwska J,Bryl E,Zorena K,Balon J,Foerster J,Myśliwski A

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Malnutrition is a widespread but largely unrecognized problem in aged patients, more so as it is a contributing factor to the increased morbidity and mortality in this age group. Since direct measurements of body composition are not possible in a large number of patients, good anthropometric reference data a...

journal_title：Gerontology

authors： Bonnefoy M,Jauffret M,Kostka T,Jusot JF

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:The results of the very few histochemical studies that have been performed so far on the lectin-binding profile of normal human epidermis are mostly controversial; thus, the carbohydrate residue composition of the cell surface in the latter still remains in dispute and the possible alterations in the epiderm...

journal_title：Gerontology

authors： Georgiou S,Pasmatzi E,Monastirli A,Sakkis T,Alachioti S,Tsambaos D

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Although cross-sectional studies have demonstrated associations between visual contrast sensitivity and cognitive test performance, it remains unclear whether peripheral visual or perceptual factors explain the association. OBJECTIVE:We aimed at determining whether reducing static contrast of the study stim...

journal_title：Gerontology

authors： Anstey KJ,Butterworth P,Borzycki M,Andrews S

更新日期：2006-01-01 00:00:00

abstract：:Protein malnutrition is associated with a decreased febrile and acute phase response to infection and increased mortality. To elucidate a cause for this poor response, we assessed the effect of chronic protein malnutrition on monocyte production of the pyrogens interleukin-1 (IL-1) and tumor necrosis factor (TNF). Thi...

journal_title：Gerontology

authors： Bradley SF,Vibhagool A,Fabrick S,Terpenning MS,Kauffman CA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial. It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome. OBJECTIVE:The purpose of this study was to determine whether age in...

journal_title：Gerontology

authors： Wakabayashi I

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:It has been proposed that active engagement with life may protect against cognitive decline. However, existing instruments for measuring life engagement have covered limited domains. OBJECTIVE:To present a new instrument to measure engagement with life; the RIASEC Activities List draws on activities categor...

journal_title：Gerontology

authors： Parslow RA,Jorm AF,Christensen H,Mackinnon A

更新日期：2006-01-01 00:00:00

abstract：:The effects of long-term cigarette smoking on regional cerebral blood flow (rCBF) were studied in 67 normal male volunteers. All subjects were healthy volunteers without any past history of cerebral and pulmonary disease. rCBF decreased significantly with advancing age. Although there was no significant difference in ...

journal_title：Gerontology

authors： Yamashita K,Kobayashi S,Yamaguchi S,Kitani M,Tsunematsu T

更新日期：1988-01-01 00:00:00

abstract：:To evaluate the requirement for provocative cystometry in urodynamic investigation in the elderly with urinary incontinence, 100 consecutive patients, who were referred on the basis of defined clinical criteria, were first studied by supine cystometry followed by provocative tests where necessary. The most satisfactor...

journal_title：Gerontology

authors： Eastwood HD

更新日期：1986-01-01 00:00:00

abstract：:We examined the presenting features, clinical course and prognosis in relation to age in 121 patients with primary biliary cirrhosis (PBC) for a mean follow-up of 4.6 years. 35 patients (29%) were over age 65 years at presentation/detection. There was a higher proportion of patients asymptomatic of liver disease in th...

journal_title：Gerontology

authors： Lehmann AB,Bassendine MF,James OF

更新日期：1985-01-01 00:00:00

abstract：:Older adults have surprisingly high levels of well-being, which has been referred to as a paradox in the past. Improved emotion regulation has been suggested to underlie these high levels of well-being. Later life is also a period with enhanced exposure to critical life events, and this comes with risks. During such t...

journal_title：Gerontology

authors： Brose A,Ebner-Priemer UW

更新日期：2015-01-01 00:00:00

abstract：:Cyclic AMP-dependent and -independent protein kinase have been isolated from livers of rats at 3, 9, 18 and 30 months of age. A preliminary characterization reported here reveals that in addition to a decrease in their activities due to ageing and a likely shift to cyclic AMP-independent casein kinase activity at 30 m...

journal_title：Gerontology

authors： Kumar R,Chiero L,Rodriguez D

更新日期：1984-01-01 00:00:00

abstract：:The experimental evidence is reviewed which bears on the theory that aging in mammalian cells may be related to a decline in the efficiency of normal DNA repair processes. Although the data are as yet fragmentary, they do suggest that there is an age-associated decline in the capacity of cells to perform at least cert...

journal_title：Gerontology

authors： Little JB

更新日期：1976-01-01 00:00:00

abstract：INTRODUCTION:Many falls in older adults occur during walking and result in lateral falls. The ability to perform a recovery step after balance perturbation determines whether a fall will occur. AIM:To investigate age-related changes in first recovery step kinematics and kinematic adaptations over a wide range of later...

journal_title：Gerontology

authors： Nachmani H,Shani G,Shapiro A,Melzer I

更新日期：2020-01-01 00:00:00

abstract：:Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because ...

journal_title：Gerontology

authors： Yu KR,Kang KS

更新日期：2013-01-01 00:00:00

abstract：:The purpose of this study was to examine the effects of a multifactorial memory training program designed for normal older adults. The multifactorial program involved the training of three components that are critical to memory functioning: recoding operations, attentional functions and relaxation. Two controls groups...

journal_title：Gerontology

authors： Stigsdotter A,Bäckman L

更新日期：1989-01-01 00:00:00

abstract：:Both ageing and vitamin C (VC) deficiency result in immune defect. Since low serum and tissue levels of VC are found in the elderly, we have in a placebo-controlled study, tested the effect of VC supplements (500 mg/day i.m. for 1 month) on various immune parameters. Indeed, VC enhances the proliferative response of T...

journal_title：Gerontology

authors： Kennes B,Dumont I,Brohee D,Hubert C,Neve P

更新日期：1983-01-01 00:00:00

abstract：:Although it is usually assumed that Lamarckian inheritance does not and cannot occur, molecular mechanisms by which non-mutational changes acquired in one generation can be transmitted to the next are now known. These mechanisms involve changes in chromatin structure, rather than changes in DNA base sequence. It is ar...

journal_title：Gerontology

authors： Jablonka E,Lamb MJ

更新日期：1990-01-01 00:00:00

abstract：:For logarithmically growing cultures of the human diploid cell lines WI-38 and WI-26, there is an exponential increase in the fraction of cells not incorporating [3H]dT under conditions of continuous labelling. Thymidine uptake, phosphorylation and incorporation into DNA can be correlated with cell proliferation. In a...

journal_title：Gerontology

authors： Cristofalo VJ

更新日期：1976-01-01 00:00:00

abstract：:The hippocampus is a structure equipped with a high degree of flexibility and adaptation. In contrast to most structures of the adult central nervous system, the hippocampus can rely on a form of plasticity known as neurogenesis. The continuous provision of new neurons derived from resident adult neural stem cells app...

journal_title：Gerontology

authors： Couillard-Despres S,Iglseder B,Aigner L

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Six-metre walking speed (SMWS) is a commonly used test for measuring functional performance in older people. However, apart from lower limb strength, few studies have examined the range of physiological and psychological factors that influence performance in this test. OBJECTIVE:To investigate the relative ...

journal_title：Gerontology

authors： Tiedemann A,Sherrington C,Lord SR

更新日期：2005-11-01 00:00:00

abstract：:The distribution of sister chromatid exchange (SCE) points has been analyzed in cultured lymphocytes from three age-groups of 30 females (n = 10; young: 13-20, middle-aged: 30-55, old: 75-84 years). The observed interchromosomal SCE distribution is in good agreement with the results of previous workers, significant ag...

journal_title：Gerontology

authors： Vormittag W

更新日期：1983-01-01 00:00:00

abstract：:Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...

journal_title：Gerontology

authors： Peng MT,Hsü HK

更新日期：1982-01-01 00:00:00

abstract：:Dietary intake, sunlight exposure and 25-hydroxy-vitamin D levels were estimated in 62 patients admitted to a geriatric assessment unit. There was a significant correlation between vitamin D intake and 25-hydroxy-vitamin D levels but none between sunlight exposure and these. This suggests that in old age dietary defic...

journal_title：Gerontology

authors： Nayal AS,MacLennan WJ,Hamilton JC,Rose P,Kong M

更新日期：1978-01-01 00:00:00

abstract：OBJECTIVE:A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of peroxide-containing strip-based tooth whitening among subjects with medication-induced hyposalivation. METHODS:Eligibility for this tooth whitening study was limited to dentate adults takin...

journal_title：Gerontology

authors： Papas AS,Kugel G,Singh M,Barker ML,Gerlach RW

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Orthostatic hypotension (OH) is common in older adults and associated with increased morbidity and mortality, loss of independence and high health-care costs. Standing up slowly is a recommended non-pharmacological intervention. However, the effectiveness of this advice has not been well studied. OBJECTIVES...

journal_title：Gerontology

authors： de Bruïne ES,Reijnierse EM,Trappenburg MC,Pasma JH,de Vries OJ,Meskers CG,Maier AB

更新日期：2017-01-01 00:00:00

abstract：:Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional altera...

journal_title：Gerontology

authors： Wang M,Monticone RE,Lakatta EG

更新日期：2014-01-01 00:00:00

abstract：:Sera from 40 elderly individuals ranging in age from 60 to 94 years were tested for the presence of antibodies to varicella-zoster virus (VZV)-specific proteins. Sodium dodecylsulfate polyacrylamide gel electrophoresis analysis of lysates of VZV-infected BSC-1 cells labeled with either [35S]methionine or [3H]mannose a...

journal_title：Gerontology

authors： Vafai A,Mahalingam R,Zerbe G,Wellish M,Gilden DH

更新日期：1988-01-01 00:00:00