Neurogenesis, cellular plasticity and cognition: the impact of stem cells in the adult and aging brain--a mini-review.

abstract：:In the United States, an increasing proportion of all forms of reactivation tuberculosis occurs in patients over the age of 60 years. Atypical presentations and presence of chronic illness obscure the diagnosis of tuberculosis in the elderly. Prompt diagnosis requires a high index of suspicion and aggressive procedure...

journal_title：Gerontology

authors： Nagami P,Yoshikawa TT

更新日期：1984-01-01 00:00:00

abstract：:The experimental evidence is reviewed which bears on the theory that aging in mammalian cells may be related to a decline in the efficiency of normal DNA repair processes. Although the data are as yet fragmentary, they do suggest that there is an age-associated decline in the capacity of cells to perform at least cert...

journal_title：Gerontology

authors： Little JB

更新日期：1976-01-01 00:00:00

abstract：:Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...

journal_title：Gerontology

authors： Peng MT,Hsü HK

更新日期：1982-01-01 00:00:00

abstract：:We quantitated the skin elastic fibers of the papillary and reticular dermis using specific staining procedure followed by automated computerized image analysis. Fifty skin biopsies of patients consulting for cardiovascular risk factors were studied. The following parameters were estimated: surface area (% of total su...

journal_title：Gerontology

authors： Robert C,Lesty C,Robert AM

更新日期：1988-01-01 00:00:00

abstract：:In three mouse lineages it was found that during the 18- to 60-day interval after formalin fixation, brain weight was inversely proportional to the age at sacrifice, as was the decline in the weight of the brain during this period. In a second study using rat subjects it was confirmed that the aging difference is due ...

journal_title：Gerontology

authors： Douglas RJ,Clark GM,Truncer PC,Treneer CM

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:The common cause account suggests that there is a third factor causing aging effects in both sensory and cognitive functioning, hypothesized to be the integrity of the central nervous system [Lindenberger and Baltes; Psychol Aging 1994;9:339-355]. Importantly, the common cause account was developed based on ...

journal_title：Gerontology

authors： Sternäng O,Jonsson B,Wahlin A,Nyberg L,Nilsson LG

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Dual-task-based assessment tests failed to establish a dependable relationship between dual-task-related gait changes and the risk of falls in the elderly. OBJECTIVE:The aim of this study was to examine whether changes in gait while counting backward could be associated with the occurrence of a first fall a...

journal_title：Gerontology

authors： Beauchet O,Allali G,Annweiler C,Berrut G,Maarouf N,Herrmann FR,Dubost V

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease ...

journal_title：Gerontology

authors： Barnett BP,Handa JT

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Age-related functional decline elevates the risk of car accidents. Whether specific cognitive impairments and physical frailty increase the risk of car accidents is still unclarified. OBJECTIVE:This study examines the association between car accidents, frailty, and cognitive function, owing to an increase...

journal_title：Gerontology

authors： Doi T,Ishii H,Tsutsumimoto K,Nakakubo S,Kurita S,Shimada H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Fall incidents and their negative outcomes represent a considerable problem in hospitals, especially in geriatric wards, and require implementation of strategies to prevent these undesirable events. For this reason, the College of Geriatrics, a body funded by the Belgian Government to set up quality improvem...

journal_title：Gerontology

authors： Coussement J,Dejaeger E,Lambert M,Van Den Noortgate N,De Paepe L,Boonen S,Schoevaerdts D,Milisen K

更新日期：2009-01-01 00:00:00

abstract：:Both ageing and vitamin C (VC) deficiency result in immune defect. Since low serum and tissue levels of VC are found in the elderly, we have in a placebo-controlled study, tested the effect of VC supplements (500 mg/day i.m. for 1 month) on various immune parameters. Indeed, VC enhances the proliferative response of T...

journal_title：Gerontology

authors： Kennes B,Dumont I,Brohee D,Hubert C,Neve P

更新日期：1983-01-01 00:00:00

abstract：:To evaluate the requirement for provocative cystometry in urodynamic investigation in the elderly with urinary incontinence, 100 consecutive patients, who were referred on the basis of defined clinical criteria, were first studied by supine cystometry followed by provocative tests where necessary. The most satisfactor...

journal_title：Gerontology

authors： Eastwood HD

更新日期：1986-01-01 00:00:00

abstract：:Form birefringence curves and linear dichroic properties of aging rat tendons are different from those of adult controls. The steepness of the form birefringence curves and the increased retardations found in aging tendons are ascribed to an increase in collagen aggregation accompanied by loss of tissue water. Based o...

journal_title：Gerontology

authors： Mello ML,Vidal BC,de Carvalho AC,Caseiro-Filho AC

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The leading causes of death and disability in the elderly are from cardiovascular and cerebrovascular diseases. The biological role of stem cells in the hematopoietic system has been well characterized and has led to the development of hematopoietic stem and progenitor cell (HSPC) transplantation for the tre...

journal_title：Gerontology

authors： Williams BA,Keating A

更新日期：2008-01-01 00:00:00

abstract：:Neurofilament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer's disease. The abnormally proliferated neurofilament was characterized by immunostaining and electron microscopy. The intracytoplasmic neurofilament ...

journal_title：Gerontology

authors： Takeda M,Nishimura T,Kudo T,Tanimukai S,Gotow T,Tanabe H,Miki T,Nakamura Y,Niigawa H,Morita H

更新日期：1991-01-01 00:00:00

abstract：:New neurons are continuously generated and added to neural circuits in the adult brain. However, increasing age imposes changes in neural progenitor cells and their microenvironment that lead to a reduction of neurogenesis. Age-related decreased production of new neurons in the neurogenic dentate gyrus has been associ...

journal_title：Gerontology

authors： Seib DR,Martin-Villalba A

更新日期：2015-01-01 00:00:00

abstract：:We examined age- and diet-related alterations in RNA poly(A) tail length using high-resolution gel electrophoresis followed by Northern hybridization. The results demonstrate conclusively that there is no age-related decrease in the size of the Poly(A) tail of RNA isolated from the male Fischer 344 rat. In contrast, o...

journal_title：Gerontology

authors： Kristal BS,Conrad CC,Richarson A,Yu BP

更新日期：1993-01-01 00:00:00

abstract：:The biological rhythms of rectal temperature were documented in young (circadian variations) and elderly (circadian and seasonal variations) human subjects either in apparent good health or suffering from senile dementia of Alzheimer type (SDAT). All the subjects were synchronized. Data obtained showed a decrease of t...

journal_title：Gerontology

authors： Touitou Y,Reinberg A,Bogdan A,Auzéby A,Beck H,Touitou C

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Many studies have demonstrated an inverse relationship between gait performance and cognitive impairment. The main purposes of this study were: (1) to design and validate a complex gait test (CGT) in older people, (2) to analyze the effects of age and sex on CGT, and (3) to analyze the association between CG...

journal_title：Gerontology

authors： Latorre Román PÁ,Muñoz Jiménez M,Salas Sánchez J,Consuegra González P,Moreno Del Castillo R,Herrador Sánchez JA,López Ivanco MDA,Linares Jiménez C,Navas Morales JF,Párraga Montilla JA

更新日期：2020-01-01 00:00:00

abstract：:Dysfunction associated with the aging process positions aging as a leading culprit for development of devastating diseases and mounting health-care costs. Many age-associated conditions for which aging increases risk are neurological disorders with no effective treatments, including Alzhei-mer's disease. As the propor...

journal_title：Gerontology

authors： Castellano JM

更新日期：2019-01-01 00:00:00

abstract：:During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...

journal_title：Gerontology

authors： Moran D,Korzets Z,Bernheim J,Bernheim J,Yaretzky A

更新日期：1993-01-01 00:00:00

abstract：:Some authors have hypothesised that life expectancy at birth could reach 100 years in developed countries in the next decades. Using recent data for French women, it is shown that life expectancy changes from 1993 to 2016 are mainly linked to mortality rates of oldest women. In recent years, it happened that life expe...

journal_title：Gerontology

authors： Le Bourg E

更新日期：2019-01-01 00:00:00

abstract：:We examined the presenting features, clinical course and prognosis in relation to age in 121 patients with primary biliary cirrhosis (PBC) for a mean follow-up of 4.6 years. 35 patients (29%) were over age 65 years at presentation/detection. There was a higher proportion of patients asymptomatic of liver disease in th...

journal_title：Gerontology

authors： Lehmann AB,Bassendine MF,James OF

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Infections due to Streptococcus pneumoniae are the major cause of adult community-acquired pneumonia, especially in elderly persons with chronic medical conditions. Despite their well-documented efficacy against bacteraemic disease and deaths in the elderly population, pneumococcal polysaccharide vaccines ar...

journal_title：Gerontology

authors： Wagner C,Popp W,Posch M,Vlasich C,Rosenberger-Spitzy A

更新日期：2003-07-01 00:00:00

abstract：:Demented elderly patients unable to eat independently and often refusing food are threatened by malnutrition. Therefore, we determined in 6 female patients aged 74-100 with senile dementia the average daily food consumption within a 3-week period by the exact weighing methods on six occasions. The average daily energy...

journal_title：Gerontology

authors： Stähelin HB,Hofer HO,Vogel M,Held C,Seiler WO

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Previous extensive clinical studies, using angiography or ultrasound, investigated the influence of alimentary, medicamentous and other antiatherosclerotic measures on the degree of atherosclerosis. The following signs of regression were found: clinical improvement, changes in tonus of vascular walls, format...

journal_title：Gerontology

authors： Kunz J

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder in middle and late age. Ribosomal RNA (rRNA) genes are located in the nucleolus (nucleolar organizer regions = NORs). There are increased deposits of beta-amyloid protein in the brains of the patients with AD and aged individuals with Down's syndrome (...

journal_title：Gerontology

authors： Dönmez-Altuntaş H,Akalin H,Karaman Y,Demirtaş H,Imamoğlu N,Ozkul Y

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Although foot pain has been linked to fall risk, contributions of pain severity, foot posture, or foot function are unclear. These factors were examined in a cohort of older adults. OBJECTIVE:The purpose of this study was to examine the associations of foot pain, severity of foot pain, and measures of foot ...

journal_title：Gerontology

authors： Awale A,Hagedorn TJ,Dufour AB,Menz HB,Casey VA,Hannan MT

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Due to declining birthrates and an increasing aging population, shortage of the caregiving labor force has become a global issue. Among various efforts toward the solution, introducing robotic products for assistance could provide an effective way to help older adults in their daily lives. As previous studie...

journal_title：Gerontology

authors： Tu YC,Chien SE,Yeh SL

更新日期：2020-01-01 00:00:00

abstract：:One of the problems associated with using random-source dogs to study in vivo vascular responses is their unknown background. Since aging is known to influence vascular responses, unknown variations in age could influence experimental results. The vast majority of aging studies examine arteries in vitro. This study wa...

journal_title：Gerontology

authors： Kaiser L,Ptu S

更新日期：1992-01-01 00:00:00