Abstract:
:New neurons are continuously generated and added to neural circuits in the adult brain. However, increasing age imposes changes in neural progenitor cells and their microenvironment that lead to a reduction of neurogenesis. Age-related decreased production of new neurons in the neurogenic dentate gyrus has been associated with memory impairments. Several mechanisms are known that might counteract this decline in cognitive functions. Here, we give an overview of ageing-related changes in neurogenesis in the brain of humans and rodents. We discuss possible causes for reduced neurogenesis with age, its consequences on cognition, and how neurogenesis might be restored in old age.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Seib DR,Martin-Villalba Adoi
10.1159/000368575subject
Has Abstractpub_date
2015-01-01 00:00:00pages
327-35issue
4eissn
0304-324Xissn
1423-0003pii
000368575journal_volume
61pub_type
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