Characterization of intracytoplasmic neurofilament accumulation in hamster brain caused by Alzheimer buffy coat inoculation: comparison with experimental neurofibrillary changes produced by aluminum intoxication.


:Neurofilament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer's disease. The abnormally proliferated neurofilament was characterized by immunostaining and electron microscopy. The intracytoplasmic neurofilament accumulation was positively stained with anti-tau and anti-ubiquitin, but not with antibody against paired helical filaments. Experimental neurofibrillary changes were produced in the rabbit brain by aluminum injection, and the proliferated neurofilaments in the rabbit brain were compared with those in the hamster brain inoculated with Alzheimer buffy coat. The results indicate that the long pathological process in the hamster brain is triggered by Alzheimer's buffy coat inoculation which results in intracytoplasmic accumulation of modified neurofilaments.






Takeda M,Nishimura T,Kudo T,Tanimukai S,Gotow T,Tanabe H,Miki T,Nakamura Y,Niigawa H,Morita H





Has Abstract,Author List Incomplete


1991-01-01 00:00:00








37 Suppl 1


  • Deficiency of the growth hormone-insulin-like growth factor-I axis potentially involved in age-related alterations in body composition.

    abstract::Because the body composition effects of growth hormone and insulin-like growth factor-I (IGF-I) are opposite to those of advancing age, it has been hypothesized that the decreased activity of the growth hormone-IGF-I axis is partly responsible for the loss of bone and muscle mass that characterizes normal human aging....


    pub_type: 杂志文章


    authors: Boonen S,Lesaffre E,Aerssens J,Pelemans W,Dequeker J,Bouillon R

    更新日期:1996-01-01 00:00:00

  • Perceived Stress and Mild Cognitive Impairment among 32,715 Community-Dwelling Older Adults across Six Low- and Middle-Income Countries.

    abstract:BACKGROUND:Perceived stress may be a modifiable risk factor for mild cognitive impairment (MCI) and ultimately dementia, but studies on this topic from low- and middle-income countries (LMICs) are lacking. OBJECTIVE:We assessed the association between perceived stress and MCI in six LMICs (China, Ghana, India, Mexico,...


    pub_type: 杂志文章


    authors: Koyanagi A,Oh H,Vancampfort D,Carvalho AF,Veronese N,Stubbs B,Lara E

    更新日期:2019-01-01 00:00:00

  • Total knee arthroplasty in the elderly: patients' self-appraisal 6 and 12 months postoperatively.

    abstract::The objective of this work was to study patients' self-appraisal of total knee arthroplasty (TKA) 6 and 12 months postoperatively, and to establish which factors determine dissatisfaction from surgery. The study group consisted of 79 patients subjected to TKA who underwent rehabilitation in a specialized institution f...


    pub_type: 杂志文章


    authors: Dickstein R,Heffes Y,Shabtai EI,Markowitz E

    更新日期:1998-01-01 00:00:00

  • Psychometric Properties of the MyotonPRO in Dementia Patients with Paratonia.

    abstract:BACKGROUND:Paratonia is a distinctive form of hypertonia, causing loss of functional mobility in early stages of dementia to severe high muscle tone and pain in the late stages. For assessing and evaluating therapeutic interventions, objective instruments are required. OBJECTIVE:Determine the psychometric properties o...


    pub_type: 杂志文章,多中心研究


    authors: Drenth H,Zuidema SU,Krijnen WP,Bautmans I,van der Schans C,Hobbelen H

    更新日期:2018-01-01 00:00:00

  • Cost-Effectiveness of a Multifaceted Podiatry Intervention for the Prevention of Falls in Older People: The REducing Falls with Orthoses and a Multifaceted Podiatry Intervention Trial Findings.

    abstract:BACKGROUND:Falls are a major cause of morbidity among older people. Multifaceted interventions may be effective in preventing falls and related fractures. OBJECTIVE:To evaluate the cost-effectiveness alongside the REducing Falls with Orthoses and a Multifaceted podiatry intervention (REFORM) trial. METHODS:REFORM was...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Corbacho B,Cockayne S,Fairhurst C,Hewitt CE,Hicks K,Kenan AM,Lamb SE,MacIntosh C,Menz HB,Redmond AC,Rodgers S,Scantlebury A,Watson J,Torgerson DJ,on behalf of the REFORM study.

    更新日期:2018-01-01 00:00:00

  • Pulmonary embolism in the elderly: clinical, instrumental and laboratory aspects.

    abstract:OBJECTIVE:To focus on diagnostic and therapeutic problems of pulmonary embolism in the elderly. METHODS:Retrospective analysis of 5 years of clinical, instrumental, and laboratory data (collected at the time of hospital admission) for patients 65 years and older with pulmonary embolism proven by a high-probability sci...


    pub_type: 杂志文章


    authors: Masotti L,Ceccarelli E,Cappelli R,Guerrini M,Forconi S

    更新日期:2000-07-01 00:00:00

  • Aging-related genes in mesenchymal stem cells: a mini-review.

    abstract::Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because ...


    pub_type: 杂志文章,评审


    authors: Yu KR,Kang KS

    更新日期:2013-01-01 00:00:00

  • Recovery of functional impairment after acute illness and mortality: one-year follow-up study.

    abstract:BACKGROUND:Functional status in older people is a dynamic situation, which makes it necessary to evaluate functional capacity at different times to determinate their prognostic value. OBJECTIVE:To examine the association between functional status (baseline and change after acute illness) and mortality and functional c...


    pub_type: 杂志文章


    authors: Baztán JJ,Gálvez CP,Socorro A

    更新日期:2009-01-01 00:00:00

  • Health-related internet use in older primary care patients.

    abstract:BACKGROUND:Adults aged 65 years and older stand to benefit from the accumulating wealth of Internet-based health resources, including online interventions to assist in the self-management of chronic health conditions. However, concerns have been expressed that lesser Internet use and familiarity among older adults may ...


    pub_type: 杂志文章


    authors: Crabb RM,Rafie S,Weingardt KR

    更新日期:2012-01-01 00:00:00

  • Zika Virus Infection in the Elderly: Possible Relationship with Guillain-Barré Syndrome.

    abstract::The Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or ...


    pub_type: 杂志文章,评审


    authors: Savino W,Messias CV,Mendes-da-Cruz DA,Passos P,Ferreira AC,Nascimento OJ

    更新日期:2017-01-01 00:00:00

  • Prevalence and facility level correlates of need for wheelchair seating assessment among long-term care residents.

    abstract:BACKGROUND:Wheelchairs are frequently prescribed for residents with mobility impairments in long-term care. Many residents receive poorly fitting wheelchairs, compromising functional independence and mobility, and contributing to subsequent health issues such as pressure ulcers. The extent of this problem and the facto...


    pub_type: 杂志文章


    authors: Giesbrecht EM,Mortenson WB,Miller WC

    更新日期:2012-01-01 00:00:00

  • Aging, longevity, and diet: historical remarks on calorie intake reduction.

    abstract:BACKGROUND:The link between longevity and diet is of great interest to biological and gerontological research. The fact that relevant knowledge has generally been available for many centuries is often not remarked upon. OBJECTIVE:This article examines three aspects of early modern Western medicine which thematize the ...


    pub_type: 历史文章,杂志文章


    authors: Schafer D

    更新日期:2005-03-01 00:00:00

  • (Na+-K+)-ATPase activity and ouabain-binding sites in the cerebral cortex of young and aged Fischer-344 rats.

    abstract::(Na+-K+)-ATPase is an enzyme responsible for ionic homeostasis in excitable tissues. Thus, the activity of this enzyme is essential for the maintenance of optimal function of the cerebral cortex. Although abnormalities of cerebral oxidative metabolism have been described in aging, these abnormalities do not appear to ...


    pub_type: 杂志文章


    authors: LaManna JC,Doull G,McCracken K,Harik SI

    更新日期:1983-01-01 00:00:00

  • The symptomatic post-surgical stomach--an endoscopic review.

    abstract::100 consecutive endoscopies in elderly patients referred with symptoms after previous gastric surgery are reviewed. 57% showed positive findings, and the procedure was found particularly useful in making definitive diagnoses in patients presenting with dyspepsia and upper gastro-intestinal bleeding. The incidence of g...


    pub_type: 杂志文章


    authors: Gibbins FJ,Gupta SD,Sen I

    更新日期:1985-01-01 00:00:00

  • Physiological and psychological predictors of walking speed in older community-dwelling people.

    abstract:BACKGROUND:Six-metre walking speed (SMWS) is a commonly used test for measuring functional performance in older people. However, apart from lower limb strength, few studies have examined the range of physiological and psychological factors that influence performance in this test. OBJECTIVE:To investigate the relative ...


    pub_type: 杂志文章


    authors: Tiedemann A,Sherrington C,Lord SR

    更新日期:2005-11-01 00:00:00

  • Molecular mechanisms of ageing. A critique.

    abstract::Two kinds of evidence, taken in conjunction, indicate that Orgel's theory is inapplicable to a wide range of disorders of senescence in man. The age dependence and the anatomical distribution of the lesions of such disorders imply a Burnet type 'forbidden clone' theory of ageing. We describe the difficulty of establis...


    pub_type: 杂志文章


    authors: Burch PR,Jackson D

    更新日期:1976-01-01 00:00:00

  • Effect of cell-bound proteins on the in vivo survival of circulating blood cells.

    abstract::Normal circulating red blood cells (RBCs) and platelets have been shown to have small amounts of IgG on their membranes. The cell-bound IgG may be cytophilic (IgG nonspecifically adsorbed from the plasma) and/or IgG autoantibody. It has been suggested that most of the RBC-bound IgG is on older RBCs and is an autoantib...


    pub_type: 杂志文章,评审


    authors: Garratty G

    更新日期:1991-01-01 00:00:00

  • Care transitions: a leverage point for safe and effective medication use in older adults--a mini-review.

    abstract::Older adults often face challenges as they transition out of the acute care hospital, especially with regard to adhering to their medications. In this narrative review, we discuss medication adherence in older adults across the continuum of care, describing reasons for nonadherence, methods to assess adherence and too...


    pub_type: 杂志文章,评审


    authors: Mixon AS,Neal E,Bell S,Powers JS,Kripalani S

    更新日期:2015-01-01 00:00:00

  • Cytoplasmic and nuclear binding of estradiol in the brain and pituitary of old female rats.

    abstract::The subcellular distribution of estradiol following the in vivo administration of 3H-estradiol, cytosol and nuclear estrogen receptor after in vitro incubation with 3H-estradiol were studied in young adult female rats (3-6 months old) and old female rats (over 18 months old). After intravenous injection of 3H-estradio...


    pub_type: 杂志文章


    authors: Jiang MJ,Peng MT

    更新日期:1981-01-01 00:00:00

  • Overactivity of tumor necrosis factor-alpha but not interleukin 6 is associated with low natural killer cytotoxic activity in the elderly.

    abstract::In this paper we asked whether the increased production of two proinflammatory cytokines-tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL6) in the absence of the inflammatory stimulus, a phenomenon frequently occurring in the elderly, may contribute to the decrease of natural killer (NK) cytotoxic activit...


    pub_type: 临床试验,杂志文章


    authors: Myśliwska J,Bryl E,Zorena K,Balon J,Foerster J,Myśliwski A

    更新日期:1997-01-01 00:00:00

  • Modelling survivorship kinetics: a two-parameter model.

    abstract::A mathematical model of survivorship kinetics is presented. It takes into account both deterministic and stochastic aspects of survival curves. Earlier reports [Piantanelli: Arch Gerontol Geriatr 1986;5:107-118; Piantanelli: Ann NY Acad Sci 1988; 521:99-109] described a model capable of making distinct predictions on ...


    pub_type: 杂志文章


    authors: Piantanelli L,Rossolini G,Nisbet R

    更新日期:1992-01-01 00:00:00

  • Effectiveness of influenza vaccine in the elderly.

    abstract:OBJECTIVE:Each year, influenza and its complications account for 10,000-40,000 excess deaths in the United States. Over 80% of these deaths occur among the elderly. The Advisory Committee on Immunization Practices for the US Public Health Service and others recommend that all persons 65 years of age and older as well a...


    pub_type: 杂志文章


    authors: Nichol KL,Margolis KL,Wouremna J,von Sternberg T

    更新日期:1996-01-01 00:00:00

  • Postural influences on urinary incontinence in the elderly.

    abstract::To evaluate the requirement for provocative cystometry in urodynamic investigation in the elderly with urinary incontinence, 100 consecutive patients, who were referred on the basis of defined clinical criteria, were first studied by supine cystometry followed by provocative tests where necessary. The most satisfactor...


    pub_type: 杂志文章


    authors: Eastwood HD

    更新日期:1986-01-01 00:00:00

  • Thymidine labelling index as a criterion of aging in vitro.

    abstract::For logarithmically growing cultures of the human diploid cell lines WI-38 and WI-26, there is an exponential increase in the fraction of cells not incorporating [3H]dT under conditions of continuous labelling. Thymidine uptake, phosphorylation and incorporation into DNA can be correlated with cell proliferation. In a...


    pub_type: 杂志文章


    authors: Cristofalo VJ

    更新日期:1976-01-01 00:00:00

  • Nosocomial infection and antibiotic utilization in geriatric patients: a pilot prospective surveillance program in skilled nursing facilities.

    abstract::Prospective surveillance of nosocomial infection was conducted at seven skilled proprietary nursing facilities in Orange County, Calif., USA. The average incidence of facility-acquired infection was 5.2 infections/1,000 patient days. The most common source of infection was urinary tract (47%), followed by respiratory ...


    pub_type: 杂志文章


    authors: Lee YL,Thrupp LD,Friis RH,Fine M,Maleki P,Cesario TC

    更新日期:1992-01-01 00:00:00

  • Ageing of the skin: study of elastic fiber network modifications by computerized image analysis.

    abstract::We quantitated the skin elastic fibers of the papillary and reticular dermis using specific staining procedure followed by automated computerized image analysis. Fifty skin biopsies of patients consulting for cardiovascular risk factors were studied. The following parameters were estimated: surface area (% of total su...


    pub_type: 杂志文章


    authors: Robert C,Lesty C,Robert AM

    更新日期:1988-01-01 00:00:00

  • Factors affecting provision of successful monitoring in home Telehealth.

    abstract:AIM:To investigate acceptance and usage issues in relation to Telehealth products as used by frail older clients of the Transition Care Program and their carers. METHOD:The study design was a quasi-randomised controlled clinical trial. A stratified random sample of participants was allocated to one of five groups usin...


    pub_type: 杂志文章,随机对照试验


    authors: Wade R,Shaw K,Cartwright C

    更新日期:2012-01-01 00:00:00

  • Study of some early immunological parameters in aging humans.

    abstract::We studied the correlation between the in vitro lymphocyte proliferative response and some early parameters of lymphocyte activation in aged people. While a consistent number of elderly subjects showed significantly decreased proliferative responses to mitogen stimulation, interleukin-1 (IL-1) production and IL-2 rece...


    pub_type: 杂志文章


    authors: Amadori A,Zanovello P,Cozzi E,Ciminale V,Borghesan F,Fagiolo U,Crepaldi G

    更新日期:1988-01-01 00:00:00

  • Intraindividual variability, change, and aging: conceptual and analytical issues.

    abstract:BACKGROUND:Developmental researchers use a variety of research designs to examine aging-related changes. Most longitudinal studies of aging are based on research designs that feature successive, widely spaced, assessments to estimate changes in cognitive performance. Such designs assume that short-term variations in co...


    pub_type: 杂志文章,评审


    authors: Martin M,Hofer SM

    更新日期:2004-01-01 00:00:00

  • Do all systems age together?

    abstract:BACKGROUND:Aging changes in different body system are well described, but few studies have considered the relationship between them. OBJECTIVE:The purpose of this study was, therefore, to investigate the interrelationships between markers of aging in different parts of the body. METHODS:A cross-sectional study design...


    pub_type: 杂志文章


    authors: Aihie Sayer A,Osmond C,Briggs R,Cooper C

    更新日期:1999-01-01 00:00:00