Abstract:
BACKGROUND:Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. OBJECTIVE:To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. METHODS:A literature review. RESULTS:The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. CONCLUSIONS:Oxidative stress and complement dysregulation play a substantive role in the development of AMD.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Barnett BP,Handa JTdoi
10.1159/000346169subject
Has Abstractpub_date
2013-01-01 00:00:00pages
297-306issue
4eissn
0304-324Xissn
1423-0003pii
000346169journal_volume
59pub_type
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