The impact of environment in comparison with moderate physical exercise and dietary restriction on BDNF in the cerebral parietotemporal cortex of aged Sprague-Dawley rats.

abstract：BACKGROUND:Cognitively stimulating activities contribute to the accumulation of cognitive reserve that is proposed to be instrumental for maintaining cognitive functioning in aging. Adopting a novel, more general conceptual perspective including models of vulnerability, we argue that cognitive reserve may modify the lo...

journal_title：Gerontology

authors： Ihle A,Rimmele U,Oris M,Maurer J,Kliegel M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:There are limited psychological data on the quality of life and activities of daily living among elderly Japanese who live alone. OBJECTIVE:The aim of this study was to examine the frequency of apathy and its correlation with activities of daily living and with subjective well-being in elderly people living...

journal_title：Gerontology

authors： Yamashita K,Iijima K,Kobayashi S

更新日期：1999-09-01 00:00:00

abstract：:Cyclic AMP-dependent and -independent protein kinase have been isolated from livers of rats at 3, 9, 18 and 30 months of age. A preliminary characterization reported here reveals that in addition to a decrease in their activities due to ageing and a likely shift to cyclic AMP-independent casein kinase activity at 30 m...

journal_title：Gerontology

authors： Kumar R,Chiero L,Rodriguez D

更新日期：1984-01-01 00:00:00

abstract：:The prevalence of and risk factors for varicose veins (VV) were studied in elderly persons over 60 years of age who had visited the Tonya and Farabi Hospitals in Trabzon, a city in northeastern Turkey. VV were defined as dilated, tortuous and elongated veins of the lower extremities and were classified into four types...

journal_title：Gerontology

authors： Komsuoğlu B,Göldeli O,Kulan K,Cetinarslan B,Komsuoğlu SS

更新日期：1994-01-01 00:00:00

abstract：:Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulat...

journal_title：Gerontology

authors： Nagy V,Penninger JM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Many studies have demonstrated an inverse relationship between gait performance and cognitive impairment. The main purposes of this study were: (1) to design and validate a complex gait test (CGT) in older people, (2) to analyze the effects of age and sex on CGT, and (3) to analyze the association between CG...

journal_title：Gerontology

authors： Latorre Román PÁ,Muñoz Jiménez M,Salas Sánchez J,Consuegra González P,Moreno Del Castillo R,Herrador Sánchez JA,López Ivanco MDA,Linares Jiménez C,Navas Morales JF,Párraga Montilla JA

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The oral cavity is a reservoir for colonization and infection of systemic organs by pathogenic bacteria. It is understood that aging, tooth eruption, hormonal changes, active disease, oral hygiene, and other factors have an influence on biofilm formation and bacterial accumulation in the oral cavity. OBJECT...

journal_title：Gerontology

authors： Senpuku H,Sogame A,Inoshita E,Tsuha Y,Miyazaki H,Hanada N

更新日期：2003-09-01 00:00:00

abstract：:Neuropsychological research contributes to a better understanding of cognitive mechanisms involved in making advantageous decisions, which is important for everyday life. Using laboratory gambling tasks, it has been demonstrated that both structural and functional brain changes can result in disadvantageous decision-m...

journal_title：Gerontology

authors： Brand M,Markowitsch HJ

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The link between longevity and diet is of great interest to biological and gerontological research. The fact that relevant knowledge has generally been available for many centuries is often not remarked upon. OBJECTIVE:This article examines three aspects of early modern Western medicine which thematize the ...

journal_title：Gerontology

authors： Schafer D

更新日期：2005-03-01 00:00:00

abstract：:To investigate the mechanisms of age-related decline in synthesis of adrenal androgen, we studied the contents of cortisol (F) and dehydroepiandrosterone (DHEA) and the amounts of cytochrome P450 17 alpha-hydroxylase (P450c17) mRNA and cytochrome P450 11 beta-hydroxylase (P450c11) mRNA in young (1 year old) and senesc...

journal_title：Gerontology

authors： Ogo A,Haji M,Ohashi M,Nawata H

更新日期：1991-01-01 00:00:00

abstract：:Measurements of total exchangeable potassium and total exchangeable sodium, total body water and extracellular fluid volumes were made in 69 patients aged 30-90+ years, using multiple isotope techniques. The patients were not suffering from any chronic disorder or having potassium or diuretic therapy and were consider...

journal_title：Gerontology

authors： Cox JR,Shalaby WA

更新日期：1981-01-01 00:00:00

abstract：:Older adults often face challenges as they transition out of the acute care hospital, especially with regard to adhering to their medications. In this narrative review, we discuss medication adherence in older adults across the continuum of care, describing reasons for nonadherence, methods to assess adherence and too...

journal_title：Gerontology

authors： Mixon AS,Neal E,Bell S,Powers JS,Kripalani S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:It is known from clinical practice and observational studies that elderly patients with a diagnosis of inflammatory rheumatic diseases (IRD) bear a significantly increased risk for cardiovascular diseases such as coronary artery disease (CAD) and heart failure. The molecular mechanism, however, is still not ...

journal_title：Gerontology

authors： Bruton M,Hollan I,Xiao J,Lindroos E,Mikkelsen K,Rynning SE,Saatvedt K,Almdahl SM,Harris HE,Lundberg IE,Wick C

更新日期：2017-01-01 00:00:00

abstract：:Protein malnutrition is associated with a decreased febrile and acute phase response to infection and increased mortality. To elucidate a cause for this poor response, we assessed the effect of chronic protein malnutrition on monocyte production of the pyrogens interleukin-1 (IL-1) and tumor necrosis factor (TNF). Thi...

journal_title：Gerontology

authors： Bradley SF,Vibhagool A,Fabrick S,Terpenning MS,Kauffman CA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Despite declines in cognitive abilities, older adults often perform comparable to younger adults in everyday tasks [J Am Geriatr Soc 1999;47:172-183]. Older adults may compensate for cognitive declines by using more efficient strategies. People often improve their efficiency by switching from an algorithmic ...

journal_title：Gerontology

authors： Frank DJ,Jordano ML,Browne K,Touron DR

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To focus on diagnostic and therapeutic problems of pulmonary embolism in the elderly. METHODS:Retrospective analysis of 5 years of clinical, instrumental, and laboratory data (collected at the time of hospital admission) for patients 65 years and older with pulmonary embolism proven by a high-probability sci...

journal_title：Gerontology

authors： Masotti L,Ceccarelli E,Cappelli R,Guerrini M,Forconi S

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder in middle and late age. Ribosomal RNA (rRNA) genes are located in the nucleolus (nucleolar organizer regions = NORs). There are increased deposits of beta-amyloid protein in the brains of the patients with AD and aged individuals with Down's syndrome (...

journal_title：Gerontology

authors： Dönmez-Altuntaş H,Akalin H,Karaman Y,Demirtaş H,Imamoğlu N,Ozkul Y

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Hypoxia and aging determine on mammalian cells a stress response which implies modified production of oxidants, reactive oxygen species or reactive nitrogen species at the mitochondrial level, interfering with cell-signaling proteins and inducing mitochondrial damage, apoptosis occurrence and functional cons...

journal_title：Gerontology

authors： Zara S,Rapino M,Centurione L,di Giacomo V,Petruccelli G,Cataldi A

更新日期：2010-01-01 00:00:00

abstract：:We performed 24-hour ambulatory electrocardiographic (Holter) examinations in 50 retired hospital workers (30 men, 20 women), aged 58-85 years (mean age +/- SD: 65.9 +/- 4.6 years), with a normal clinical history, physical examination and baseline ECG. There was a significant difference between daytime and nocturnal m...

journal_title：Gerontology

authors： Ribera JM,Cruz AJ,Zamorano JL,Pérez-Casar F

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Previous studies have shown links between cognitive impairment and hypertension as well as mortality. However, combined effects of these two conditions on mortality have not been fully explored. OBJECTIVE:To assess the combined effect of cognitive impairment and hypertension on all-cause mortality among the...

journal_title：Gerontology

authors： Gombojav B,Yi SW,Sull JW,Nam CM,Ohrr H

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:compared with other vertebrate taxa, mammals possess a very limited capacity for appendage regeneration. The antlers of deer are an exception in that they are periodically lost and fully regenerated throughout the life of an individual. OBJECTIVE:in this paper we compare certain aspects of antler regenerati...

journal_title：Gerontology

authors： Kierdorf U,Kierdorf H

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Many falls in older adults occur during walking and result in lateral falls. The ability to perform a recovery step after balance perturbation determines whether a fall will occur. AIM:To investigate age-related changes in first recovery step kinematics and kinematic adaptations over a wide range of later...

journal_title：Gerontology

authors： Nachmani H,Shani G,Shapiro A,Melzer I

更新日期：2020-01-01 00:00:00

abstract：:Dementia is a symptom of a variety of specific structural brain diseases as well as several system degenerations. Alzheimer's disease presently is the commonest cause in the developed world, causing a cortical-subcortical degeneration of ascending cholinergic neurons and large pyramidal cells in the cerebral cortex. C...

journal_title：Gerontology

authors： Plum F

更新日期：1986-01-01 00:00:00

abstract：:The effect of aging on plasma erythropoietin (EPO) levels after acute hemorrhage was investigated in ovariectomized (Ovx) rats. Old (22 months), middle (mid)-aged (14 months) and adult (5-6 months) Ovx rats were studied. Rats were anesthetized with ether and bled by heart puncture (5 ml/kg). They were bled again after...

journal_title：Gerontology

authors： Wang RY,Tung YF,Wang PS

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Perceived stress may be a modifiable risk factor for mild cognitive impairment (MCI) and ultimately dementia, but studies on this topic from low- and middle-income countries (LMICs) are lacking. OBJECTIVE:We assessed the association between perceived stress and MCI in six LMICs (China, Ghana, India, Mexico,...

journal_title：Gerontology

authors： Koyanagi A,Oh H,Vancampfort D,Carvalho AF,Veronese N,Stubbs B,Lara E

更新日期：2019-01-01 00:00:00

abstract：:We use nerve tissue cultures as a model system for studying the mode of action of centrally acting drugs. Neurons in cerebellar cultures retain a number of organ-specific properties including the formation of complex synaptic networks and characteristic bioelectric activity. Electrical activity may be recorded from Pu...

journal_title：Gerontology

authors： Gähwiler BH

更新日期：1978-01-01 00:00:00

abstract：:Taurine (TAU) is thought to be a neuromodulator or an inhibitory neurotransmitter in the mammalian brain. In the periphery, TAU is involved in a wide spectrum of physiological functions. One of the most important putative physiological function of TAU is the modulation of cardiovascular activity including blood pressu...

journal_title：Gerontology

authors： Wallace DR,Dawson R Jr

更新日期：1990-01-01 00:00:00

abstract：:Mental healthcare of elderly people is a common problem in advanced countries. Recently, high technology has developed robots for use not only in factories but also for our living environment. In particular, human-interactive robots for psychological enrichment, which provide services by interacting with humans while ...

journal_title：Gerontology

authors： Shibata T,Wada K

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The prevalence of aortic stenosis is nearly 20% in octogenarians. Aortic valve replacement (AVR) is the optimal therapy choice, yet many symptomatic patients are denied this beneficent technology. Whether mechanical or bioprosthetic, aortic valves are not a scarce resource and their safety, effectiveness and...

journal_title：Gerontology

authors： Bramstedt KA

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Research on the relationship between vestibular function and falls in older people is sparse. The perception of the postural vertical (PPV) provides an indicator measure of vestibular (otolith) function in the absence of visual input and diminished somatosensory feedback. OBJECTIVE:This study examined wheth...

journal_title：Gerontology

authors： Menant JC,St George RJ,Fitzpatrick RC,Lord SR

更新日期：2012-01-01 00:00:00