Combined effects of cognitive impairment and hypertension on total mortality in elderly people: the Kangwha Cohort study.

Abstract:

BACKGROUND:Previous studies have shown links between cognitive impairment and hypertension as well as mortality. However, combined effects of these two conditions on mortality have not been fully explored. OBJECTIVE:To assess the combined effect of cognitive impairment and hypertension on all-cause mortality among the elderly people. METHODS:We followed a cohort of 2,496 residents in Kangwha County, ranging in age from 64 to 101 years as of March 1994, for all-cause mortality for 11.8 years up to December 31, 2005. We calculated hazard ratios (HR) for all-cause mortality by cognitive status and blood pressure using the Cox proportional hazards model after having controlled for confounding factors. RESULTS:1,189 people (47.6%) died during the 11.8 years of follow-up. The HR associated with severe cognitive impairment increased from 2.15 (95% CI: 1.30, 3.54) for prehypertension over 2.68 (95% CI: 1.60, 4.48) for stage 1 hypertension to 3.60 (95% CI: 1.99, 6.49) for stage 2 hypertension in women. A mortality risk of 3.67 (95% CI: 2.05, 6.57) was observed among men who had both mild cognitive impairment and stage 2 hypertension. CONCLUSION:Individuals with coexisting cognitive impairment and hypertension are at an increased risk of all-cause mortality compared with those with cognitive impairment or hypertension alone.

journal_name

Gerontology

journal_title

Gerontology

authors

Gombojav B,Yi SW,Sull JW,Nam CM,Ohrr H

doi

10.1159/000323759

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

490-6

issue

6

eissn

0304-324X

issn

1423-0003

pii

000323759

journal_volume

57

pub_type

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