Abstract:
:We use nerve tissue cultures as a model system for studying the mode of action of centrally acting drugs. Neurons in cerebellar cultures retain a number of organ-specific properties including the formation of complex synaptic networks and characteristic bioelectric activity. Electrical activity may be recorded from Purkinje cells which can be identified by direct visualization. We observed that dihydroergotoxine mesylate (DHET; active substance of Hydergine) modulated the spontaneous activity of cultured neurons. Addition of 10(-8)g/ml DHET to rat cerebellar explants led to a significant regularization of the spontaneous firing of Purkinje cells. Within the 10(-10) - 10(-5)g/ml concentration range used in these experiments, DHET had no detectalbe effect on the average firing rate.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Gähwiler BHdoi
10.1159/000212300subject
Has Abstractpub_date
1978-01-01 00:00:00pages
71-5eissn
0304-324Xissn
1423-0003journal_volume
24 Suppl 1pub_type
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