Purification of a trypsin-type protease from human umbilical vein endothelial cells which is highly sensitive to the Kunitz inhibitor domain peptide of Alzheimer's disease amyloid protein precursor.

abstract：:In this paper we asked whether the increased production of two proinflammatory cytokines-tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL6) in the absence of the inflammatory stimulus, a phenomenon frequently occurring in the elderly, may contribute to the decrease of natural killer (NK) cytotoxic activit...

journal_title：Gerontology

authors： Myśliwska J,Bryl E,Zorena K,Balon J,Foerster J,Myśliwski A

更新日期：1997-01-01 00:00:00

abstract：:Alzheimer neurofibrillary changes and senile plaques were found in a variety of distribution patterns and intensities in 50 brains of patients older than 73 years who had been carefully examined for signs of organic dementia in a geriatric unit. As noted by earlier observers, the severity of dementia usually correspon...

journal_title：Gerontology

authors： Ulrich J,Stähelin HB

更新日期：1984-01-01 00:00:00

abstract：:Research into the aetiology of osteoarthritis has for several decades been concentrated on the destruction of the articular cartilage, the initiating events being believed to be changes in the proteoglycans and subsequently in the supporting collagenous framework, whereafter the disease is irreversible. Recent evidenc...

journal_title：Gerontology

authors： Bailey AJ,Mansell JP

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial. It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome. OBJECTIVE:The purpose of this study was to determine whether age in...

journal_title：Gerontology

authors： Wakabayashi I

更新日期：2012-01-01 00:00:00

abstract：:In the United States, an increasing proportion of all forms of reactivation tuberculosis occurs in patients over the age of 60 years. Atypical presentations and presence of chronic illness obscure the diagnosis of tuberculosis in the elderly. Prompt diagnosis requires a high index of suspicion and aggressive procedure...

journal_title：Gerontology

authors： Nagami P,Yoshikawa TT

更新日期：1984-01-01 00:00:00

abstract：:The influence of age and smoking on pharmacokinetics of pindolol and propranolol was investigated. Although there was a statistically significant difference in certain pharmacokinetic parameters (maximum plasma concentration, area under the curve, elimination constant and elimination half-life) between elderly patient...

journal_title：Gerontology

authors： Hitzenberger G,Fitscha P,Beveridge T,Nüesch E,Pacha W

更新日期：1982-01-01 00:00:00

abstract：:Patients over 65 years of age admitted to an ophthalmic ward were routinely screened in a standard way practiced in Geriatric Assessment Units. The previous drug therapy of all patients was particularly noted. A classification of the patients with undetected pathology was made and an attempt to categorise the percenta...

journal_title：Gerontology

authors： Andrews J,Pandita-Gunawardena ND,Suntharalingham M

更新日期：1977-01-01 00:00:00

abstract：:Dysfunction associated with the aging process positions aging as a leading culprit for development of devastating diseases and mounting health-care costs. Many age-associated conditions for which aging increases risk are neurological disorders with no effective treatments, including Alzhei-mer's disease. As the propor...

journal_title：Gerontology

authors： Castellano JM

更新日期：2019-01-01 00:00:00

abstract：:Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional altera...

journal_title：Gerontology

authors： Wang M,Monticone RE,Lakatta EG

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:There is a need for simple clinical tools that can objectively assess the fall risk in people with dementia. Wearable sensors seem to have the potential for fall prediction; however, there has been limited work performed in this important area. OBJECTIVE:To explore the validity of sensor-derived physical ac...

journal_title：Gerontology

authors： Schwenk M,Hauer K,Zieschang T,Englert S,Mohler J,Najafi B

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:To explore predictors of functional improvement or decline in instrumental activities of daily living (IADL) among community-dwelling older people. METHODS:Of all the residents (>or=65 years, n = 1,673) living in Yoita town, Niigata prefecture, Japan, in 2000, 1,544 subjects who participated in the baseline...

journal_title：Gerontology

authors： Fujiwara Y,Yoshida H,Amano H,Fukaya T,Liang J,Uchida H,Shinkai S

更新日期：2008-01-01 00:00:00

abstract：:Theophylline kinetics were evaluated in 6 elderly (age 65-75 years) and 5 young (age 22-28 years), nonsmoking males following the oral administration of 200 mg of Elixophylline. Theophylline serum concentration in the postabsorptive phase declined in a monoexponential manner. Total body clearance, elimination half-lif...

journal_title：Gerontology

authors： Blouin RA,Erwin WG,Foster TS,Scott S

更新日期：1982-01-01 00:00:00

abstract：:Different approaches using cell culture techniques to study the biology of aging are critically described. Most of the studies concerned the relationship between cell division potential and aging. The growth potential of cells is fundamental for aging of the organism, since it relates to phenomena such as the regenera...

journal_title：Gerontology

authors： Macieira-Coelho A

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Malnutrition is a widespread but largely unrecognized problem in aged patients, more so as it is a contributing factor to the increased morbidity and mortality in this age group. Since direct measurements of body composition are not possible in a large number of patients, good anthropometric reference data a...

journal_title：Gerontology

authors： Bonnefoy M,Jauffret M,Kostka T,Jusot JF

更新日期：2002-05-01 00:00:00

abstract：:During a winter epidemic of A/H1N1 influenza virus, we evaluated the protection conferred by vaccination of 285 residents of a nursing home. Fifteen of 204 members of the nursing staff were also vaccinated. Serological determinations were performed before and after vaccination using radial hemolysis (RH) and neuramini...

journal_title：Gerontology

authors： Odelin MF,Pozzetto B,Aymard M,Defayolle M,Jolly-Million J

更新日期：1993-01-01 00:00:00

abstract：:The aim of the study was to examine the characteristics of colorectal cancer in elderly patients. The medical histories of 178 consecutive patients (79 men and 99 women) with colorectal cancer were studied from hospital records. The studied parameters were compared between three age groups: under 65 years old, 65-80 y...

journal_title：Gerontology

authors： Kemppainen M,Räihä I,Rajala T,Sourander L

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The common cause account suggests that there is a third factor causing aging effects in both sensory and cognitive functioning, hypothesized to be the integrity of the central nervous system [Lindenberger and Baltes; Psychol Aging 1994;9:339-355]. Importantly, the common cause account was developed based on ...

journal_title：Gerontology

authors： Sternäng O,Jonsson B,Wahlin A,Nyberg L,Nilsson LG

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:A large proportion of falls in older people are caused by slipping. Previous occupational safety research suggests that inadequate footwear may contribute to slipping accidents; however, no studies have assessed the slip resistance of casual footwear. OBJECTIVE:To evaluate the slip resistance of different t...

journal_title：Gerontology

authors： Menz HB,Lord ST,McIntosh AS

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Orthostatic hypotension (OH) is common in older adults and associated with increased morbidity and mortality, loss of independence and high health-care costs. Standing up slowly is a recommended non-pharmacological intervention. However, the effectiveness of this advice has not been well studied. OBJECTIVES...

journal_title：Gerontology

authors： de Bruïne ES,Reijnierse EM,Trappenburg MC,Pasma JH,de Vries OJ,Meskers CG,Maier AB

更新日期：2017-01-01 00:00:00

abstract：:A brief review is given of the use of fluoride, mithramycin, glucagon, actinomycin D, calcitonins and diphosphonates for treatment of Paget's disease of bone. The decision regarding treatment, effectiveness of the drugs, the incidence of side effects and assessment of clinical, biochemical, histological, radiological ...

journal_title：Gerontology

authors： Chakravorty NK

更新日期：1979-01-01 00:00:00

abstract：:The heat shock protein (HSP) system is a mechanism of cell defense induced by stress, constitutively expressed during basal conditions and essential to the maintenance of cellular integrity. Acutely induced HSP synthesis decreases with aging, but the effect of age on the basal expression of HSP70 has not been specific...

journal_title：Gerontology

authors： Maiello M,Boeri D,Sampietro L,Pronzato MA,Odetti P,Marinari UM

更新日期：1998-01-01 00:00:00

abstract：:Older adults often face challenges as they transition out of the acute care hospital, especially with regard to adhering to their medications. In this narrative review, we discuss medication adherence in older adults across the continuum of care, describing reasons for nonadherence, methods to assess adherence and too...

journal_title：Gerontology

authors： Mixon AS,Neal E,Bell S,Powers JS,Kripalani S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Studies have demonstrated that measures of lower quality of care and associated adverse health effects are more prevalent in for-profit nursing homes compared to not-for-profit facilities. However, these studies omit persons who receive care in the community setting, and exclusively focus on isolated clinica...

journal_title：Gerontology

authors： Friedman L,Avila S,Friedman D,Meltzer W

更新日期：2019-01-01 00:00:00

abstract：:During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...

journal_title：Gerontology

authors： Moran D,Korzets Z,Bernheim J,Bernheim J,Yaretzky A

更新日期：1993-01-01 00:00:00

abstract：:100 consecutive endoscopies in elderly patients referred with symptoms after previous gastric surgery are reviewed. 57% showed positive findings, and the procedure was found particularly useful in making definitive diagnoses in patients presenting with dyspepsia and upper gastro-intestinal bleeding. The incidence of g...

journal_title：Gerontology

authors： Gibbins FJ,Gupta SD,Sen I

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:It has been proposed that active engagement with life may protect against cognitive decline. However, existing instruments for measuring life engagement have covered limited domains. OBJECTIVE:To present a new instrument to measure engagement with life; the RIASEC Activities List draws on activities categor...

journal_title：Gerontology

authors： Parslow RA,Jorm AF,Christensen H,Mackinnon A

更新日期：2006-01-01 00:00:00

abstract：:Adhesion molecules, such as leukocyte-function-associated antigen (LFA-1 or CD11a/CD18), intercellular adhesion molecule 1 (ICAM-1 or CD54) and Hermes antigen (HCAM or CD44), have important roles in many adhesive interactions involving cells of the immune system. Since it has been shown that many immunological alterat...

journal_title：Gerontology

authors： Chiricolo M,Morini MC,Mancini R,Beltrandi E,Belletti D,Conte R

更新日期：1995-01-01 00:00:00

abstract：:Neurofilament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer's disease. The abnormally proliferated neurofilament was characterized by immunostaining and electron microscopy. The intracytoplasmic neurofilament ...

journal_title：Gerontology

authors： Takeda M,Nishimura T,Kudo T,Tanimukai S,Gotow T,Tanabe H,Miki T,Nakamura Y,Niigawa H,Morita H

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Research on the relationship between vestibular function and falls in older people is sparse. The perception of the postural vertical (PPV) provides an indicator measure of vestibular (otolith) function in the absence of visual input and diminished somatosensory feedback. OBJECTIVE:This study examined wheth...

journal_title：Gerontology

authors： Menant JC,St George RJ,Fitzpatrick RC,Lord SR

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Paratonia is a distinctive form of hypertonia, causing loss of functional mobility in early stages of dementia to severe high muscle tone and pain in the late stages. For assessing and evaluating therapeutic interventions, objective instruments are required. OBJECTIVE:Determine the psychometric properties o...

journal_title：Gerontology

authors： Drenth H,Zuidema SU,Krijnen WP,Bautmans I,van der Schans C,Hobbelen H

更新日期：2018-01-01 00:00:00