Abstract:
:Theophylline kinetics were evaluated in 6 elderly (age 65-75 years) and 5 young (age 22-28 years), nonsmoking males following the oral administration of 200 mg of Elixophylline. Theophylline serum concentration in the postabsorptive phase declined in a monoexponential manner. Total body clearance, elimination half-life, volume of distribution and protein binding were determined. There were no statistically significant differences in these kinetic parameters between the elderly and young subjects. Therefore, advancing age should not be used as a sole factor in the adjustment of theophylline dosage.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Blouin RA,Erwin WG,Foster TS,Scott Sdoi
10.1159/000212549subject
Has Abstractpub_date
1982-01-01 00:00:00pages
323-7issue
5eissn
0304-324Xissn
1423-0003journal_volume
28pub_type
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