A neuropathological study of dementia in nursing homes over a 17-year period, in Shimane Prefecture, Japan.

abstract：BACKGROUND:Historically, older adults have been disproportionately affected by disasters. In particular, homebound adults are especially at risk. As one facet of bolstering community resilience, home health agencies have been tasked with improving their patients' disaster preparedness. However, home health practitioner...

journal_title：Gerontology

authors： Wyte-Lake T,Claver M,Tubbesing S,Davis D,Dobalian A

更新日期：2019-01-01 00:00:00

abstract：:The influence of age and smoking on pharmacokinetics of pindolol and propranolol was investigated. Although there was a statistically significant difference in certain pharmacokinetic parameters (maximum plasma concentration, area under the curve, elimination constant and elimination half-life) between elderly patient...

journal_title：Gerontology

authors： Hitzenberger G,Fitscha P,Beveridge T,Nüesch E,Pacha W

更新日期：1982-01-01 00:00:00

abstract：:The spectrum of aldimine cross-link bonds of skin collagen is dependent on the localization of the examined material. In correlation to this, there is no synchronous behaviour of cross-linkage in the aging process. The age-dependent decrease of HLNL and the increase of DHLNL in the collagen of tail tendon is only unsu...

journal_title：Gerontology

authors： Ruiz-Torres A

更新日期：1978-01-01 00:00:00

abstract：INTRODUCTION:Age-related functional decline elevates the risk of car accidents. Whether specific cognitive impairments and physical frailty increase the risk of car accidents is still unclarified. OBJECTIVE:This study examines the association between car accidents, frailty, and cognitive function, owing to an increase...

journal_title：Gerontology

authors： Doi T,Ishii H,Tsutsumimoto K,Nakakubo S,Kurita S,Shimada H

更新日期：2020-01-01 00:00:00

abstract：:The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased ...

journal_title：Gerontology

authors： Zs-Nagy I,Pieri C,Giuli C,Del Moro M

更新日期：1979-01-01 00:00:00

abstract：:The specific activities of NAD-linked isocitric dehydrogenase were determined in hypothalamus, cerebellum, pons and medulla, striatum, midbrain, and cerebral cortex (which included the hippocampus) of the female Wistar rat. In ageing the specific activities of this enzyme were decreased in all regions. Chronic treatme...

journal_title：Gerontology

authors： Lai JC,Leung TK,Lim L

更新日期：1982-01-01 00:00:00

abstract：:Research into the aetiology of osteoarthritis has for several decades been concentrated on the destruction of the articular cartilage, the initiating events being believed to be changes in the proteoglycans and subsequently in the supporting collagenous framework, whereafter the disease is irreversible. Recent evidenc...

journal_title：Gerontology

authors： Bailey AJ,Mansell JP

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Falls are a significant problem for older adults. Individuals who have sustained a fall come to the attention of health care providers and are at risk of further falls. To promote the highest quality of care and reduce variation in care, a practice guideline is needed. Summarization of evidence regarding fal...

journal_title：Gerontology

authors： Moreland J,Richardson J,Chan D,O'Neill J,Bellissimo A,Grum R,Shanks L

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Paratonia is a distinctive form of hypertonia, causing loss of functional mobility in early stages of dementia to severe high muscle tone and pain in the late stages. For assessing and evaluating therapeutic interventions, objective instruments are required. OBJECTIVE:Determine the psychometric properties o...

journal_title：Gerontology

authors： Drenth H,Zuidema SU,Krijnen WP,Bautmans I,van der Schans C,Hobbelen H

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Being able to rise from a chair is an important daily life activity that requires sufficient lower extremity muscle power and postural control. OBJECTIVE:To assess the effects of an individually tailored intervention on the chair rise capacity of active and inactive community-dwelling older men and women. ...

journal_title：Gerontology

authors： Tikkanen P,Lönnroos E,Sipilä S,Nykänen I,Sulkava R,Hartikainen S

更新日期：2013-01-01 00:00:00

abstract：:We have shown that ultrastructural changes accompany ageing in the human fetal lung fibroblast strain MRC-5. In order to further characterise these changes a method has been devised to prepare subcellular fractions from MRC-5 fibroblasts using a discontinous gradient of metrizamide preceded by a low-speed centrifugati...

journal_title：Gerontology

authors： Shakespeare VA,Buchanan JH

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Proxy decision-making may be flawed by inaccurate perceptions of risk. This may be particularly true when older adults are the targets of the decisions, given the pervasive negative stereotypes about older adults. METHODS:In study 1, individuals aged 18- to 87 years (as target persons) as wel...

journal_title：Gerontology

authors： Rolison JJ,Hanoch Y,Freund AM

更新日期：2019-01-01 00:00:00

abstract：:The kinetics of cell proliferation and sister chromatid exchanges (SCE) were studied in blood lymphocytes treated by mitomycin C (MMC) in young and old human donors. In both the young and old donors MMC inhibited cell proliferation. Spontaneous SCE frequency was not age-dependent. In young donors, MMC induced a dose-r...

journal_title：Gerontology

authors： Musilová J,Michalová K,Pacovský V

更新日期：1984-01-01 00:00:00

abstract：:Form birefringence curves and linear dichroic properties of aging rat tendons are different from those of adult controls. The steepness of the form birefringence curves and the increased retardations found in aging tendons are ascribed to an increase in collagen aggregation accompanied by loss of tissue water. Based o...

journal_title：Gerontology

authors： Mello ML,Vidal BC,de Carvalho AC,Caseiro-Filho AC

更新日期：1979-01-01 00:00:00

abstract：:Mitochondrial abnormality in the skeletal muscles of 13 patients with myotonic dystrophy was analyzed by both histochemical and molecular biologic methods. Nine of 13 patients had ragged-red fibers (50 +/- 116 per 10,000 muscle fibers, mean +/- SD), and 10 patients had cytochrome c oxidase-negative fibers (41 +/- 90 p...

journal_title：Gerontology

authors： Sahashi K,Tanaka M,Tashiro M,Ohno K,Ibi T,Takahashi A,Ozawa T

更新日期：1992-01-01 00:00:00

abstract：:We performed 24-hour ambulatory electrocardiographic (Holter) examinations in 50 retired hospital workers (30 men, 20 women), aged 58-85 years (mean age +/- SD: 65.9 +/- 4.6 years), with a normal clinical history, physical examination and baseline ECG. There was a significant difference between daytime and nocturnal m...

journal_title：Gerontology

authors： Ribera JM,Cruz AJ,Zamorano JL,Pérez-Casar F

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The rate of lipogenesis and gene expression of lipogenic enzymes in white adipose tissue (WAT) of rats decreases with age. Previously, we showed the inverse relationship between serum leptin concentration and lipogenic enzymes activities in WAT of ageing rats. Based on those results, we postulated that lepti...

journal_title：Gerontology

authors： Nogalska A,Stelmanska E,Sledzinski T,Swierczynski J

更新日期：2009-01-01 00:00:00

abstract：:We have previously shown that lymphocytes from Alzheimer's disease (AD) patients are hypersensitive to ionising radiation, as revealed by their higher levels of dicentrics than those from age-matched, normal individuals. We have now examined the sensitivity of these cells to N-methyl-N-nitrosourea or methyl methanesul...

journal_title：Gerontology

authors： Tobi SE,Neary D,Itzhaki RF

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Reference values are usually defined based on blood samples from healthy men or nonpregnant women in the age range of 20-50 years. These values are not optimal for elderly patients, as many biological markers change over time and adequate reference values are important for correct clinical decisions. OBJECT...

journal_title：Gerontology

authors： Carlsson L,Lind L,Larsson A

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:Creutzfeldt-Jakob disease (CJD) is not only a disorder of the central nervous system but also affects the skeletal muscle. Subclinical skeletal muscle involvement, manifesting as hyper-creatine-kinase (CK)-emia, is rare. CASE REPORT:The patient, a 60-year-old male, developed progressive dementia, accompanie...

journal_title：Gerontology

authors： Finsterer J,Gelpi E

更新日期：2006-01-01 00:00:00

abstract：:The maximal glucocorticoid responsiveness and the adaptation degree are reduced in old rat liver as demonstrated by cortisol stimulation of RNA polymerases. Nevertheless the concentration of unoccupied 3H-dexamethasone binding sites in molybdate-stabilized cytosol of adrenalectomized old animals is significantly incre...

journal_title：Gerontology

authors： Martin H,Martin R

更新日期：1988-01-01 00:00:00

abstract：:Although the two-point discrimination test of the skin is a simple test of the sensory nerve function, there have been few studies on age-related changes in the ability to discriminate between two points in a large noninstitutionalized population. In this study we attempted (1) to determine normal values on the two-po...

journal_title：Gerontology

authors： Shimokata H,Kuzuya F

更新日期：1995-01-01 00:00:00

abstract：:During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...

journal_title：Gerontology

authors： Moran D,Korzets Z,Bernheim J,Bernheim J,Yaretzky A

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:Each year, influenza and its complications account for 10,000-40,000 excess deaths in the United States. Over 80% of these deaths occur among the elderly. The Advisory Committee on Immunization Practices for the US Public Health Service and others recommend that all persons 65 years of age and older as well a...

journal_title：Gerontology

authors： Nichol KL,Margolis KL,Wouremna J,von Sternberg T

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Functional and physiological declines in advancing age may be significant limiting factors in reduced physical activity. Sarcopenia of aging, as a normative process or disease, cannot entirely explain reduced physical activity in the elderly. OBJECTIVE:The purpose of the study was to investigate the relatio...

journal_title：Gerontology

authors： Carmeli E,Reznick AZ,Coleman R,Carmeli V

更新日期：2000-09-01 00:00:00

abstract：:Electrolytes and/or amino acids were determined in leg skeletal muscle biopsies from elderly (age range 57-75 years) and young (age range 20-35 years) apparently healthy women. When compared to the young group, the elderly one was characterized by increased levels of muscular Na+ and Cl-, while the calculated intracel...

journal_title：Gerontology

authors： Möller P,Alvestrand A,Bergström J,Fürst P,Hellström K

更新日期：1983-01-01 00:00:00

abstract：:In this paper we asked whether the increased production of two proinflammatory cytokines-tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL6) in the absence of the inflammatory stimulus, a phenomenon frequently occurring in the elderly, may contribute to the decrease of natural killer (NK) cytotoxic activit...

journal_title：Gerontology

authors： Myśliwska J,Bryl E,Zorena K,Balon J,Foerster J,Myśliwski A

更新日期：1997-01-01 00:00:00

abstract：:Mental healthcare of elderly people is a common problem in advanced countries. Recently, high technology has developed robots for use not only in factories but also for our living environment. In particular, human-interactive robots for psychological enrichment, which provide services by interacting with humans while ...

journal_title：Gerontology

authors： Shibata T,Wada K

更新日期：2011-01-01 00:00:00

abstract：:Metabolic, endocrine and biochemical variables of female hamsters were studied to define age-related alterations in their characteristics. Endurance performance, aerobic capacity and metabolic fuels and hormones were measured and compared in young-adult (2-3 months) and old (16-17 months) hamsters to determine if the ...

journal_title：Gerontology

authors： Nichols JF,Borer KT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Wheelchairs are frequently prescribed for residents with mobility impairments in long-term care. Many residents receive poorly fitting wheelchairs, compromising functional independence and mobility, and contributing to subsequent health issues such as pressure ulcers. The extent of this problem and the facto...

journal_title：Gerontology

authors： Giesbrecht EM,Mortenson WB,Miller WC

更新日期：2012-01-01 00:00:00