The pathophysiology of dementia.

abstract：:The usual features of Paget's disease of bone, e.g. large head, deafness due to involvement of the 8th cranial nerve and bowing of the legs are all well described in text books of medicine. However, some features such as platybasia with neurological deficit, involvement of the 2nd, 5th and 7th cranial nerves, hydrocep...

journal_title：Gerontology

authors： Chakravorty NK

更新日期：1978-01-01 00:00:00

abstract：:Aging is associated with far-reaching changes in physiological functions resulting in morbidity and ultimately death. Age-related frailty, insecurity and reduced physical activity contribute to a progressive loss of muscle mass and function, commonly referred to as sarcopenia. Due to the increase in life expectancy in...

journal_title：Gerontology

authors： Arnold AS,Egger A,Handschin C

更新日期：2011-01-01 00:00:00

abstract：:Anion exchange (AE) proteins are present in human neurons in the brain. Immunohistochemical data indicate that their apparent expression level increases with age, and especially with degeneration in Alzheimer's disease-affected brain areas. The increase in immunoreactivity is probably caused by changes in AE structure...

journal_title：Gerontology

authors： Bosman GJ,Renkawek K,Van Workum FP,Bartholomeus IG,De Grip WJ

更新日期：1997-01-01 00:00:00

abstract：:Still's disease is very rare in elderly patients. We report a case of Still's disease in an elderly patient that had an atypical initial presentation. A 76-year-old woman developed unexplained chronic anemia and thrombocytosis. Three years later she had acute onset of high fever, arthritis, maculopapular rash, pleurit...

journal_title：Gerontology

authors： Vilá LM,Molina MJ

更新日期：2007-01-01 00:00:00

abstract：:During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...

journal_title：Gerontology

authors： Moran D,Korzets Z,Bernheim J,Bernheim J,Yaretzky A

更新日期：1993-01-01 00:00:00

abstract：:To investigate the mechanisms of age-related decline in synthesis of adrenal androgen, we studied the contents of cortisol (F) and dehydroepiandrosterone (DHEA) and the amounts of cytochrome P450 17 alpha-hydroxylase (P450c17) mRNA and cytochrome P450 11 beta-hydroxylase (P450c11) mRNA in young (1 year old) and senesc...

journal_title：Gerontology

authors： Ogo A,Haji M,Ohashi M,Nawata H

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Previous studies have shown links between cognitive impairment and hypertension as well as mortality. However, combined effects of these two conditions on mortality have not been fully explored. OBJECTIVE:To assess the combined effect of cognitive impairment and hypertension on all-cause mortality among the...

journal_title：Gerontology

authors： Gombojav B,Yi SW,Sull JW,Nam CM,Ohrr H

更新日期：2011-01-01 00:00:00

abstract：:We review findings on spousal interrelations in old age in such key domains as cognition, well-being, and health. Therein, we demonstrate that spousal interrelations may extend developmental options but may also make an individual vulnerable to the experience of loss. We address theoretical questions concerning possib...

journal_title：Gerontology

authors： Hoppmann C,Gerstorf D

更新日期：2009-01-01 00:00:00

abstract：:In this paper we asked whether the increased production of two proinflammatory cytokines-tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL6) in the absence of the inflammatory stimulus, a phenomenon frequently occurring in the elderly, may contribute to the decrease of natural killer (NK) cytotoxic activit...

journal_title：Gerontology

authors： Myśliwska J,Bryl E,Zorena K,Balon J,Foerster J,Myśliwski A

更新日期：1997-01-01 00:00:00

abstract：:Although common among the hospitalized frail elderly, malnutrition is often unrecognized by clinicians, and its identification is fought with difficulty due to inadequate nutritional assessment methods and standards. This study compared the use of percent ideal body weight (%IBW) and anthropometry in the assessment of...

journal_title：Gerontology

authors： Lansey S,Waslien C,Mulvihill M,Fillit H

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of peroxide-containing strip-based tooth whitening among subjects with medication-induced hyposalivation. METHODS:Eligibility for this tooth whitening study was limited to dentate adults takin...

journal_title：Gerontology

authors： Papas AS,Kugel G,Singh M,Barker ML,Gerlach RW

更新日期：2009-01-01 00:00:00

abstract：:Theophylline kinetics were evaluated in 6 elderly (age 65-75 years) and 5 young (age 22-28 years), nonsmoking males following the oral administration of 200 mg of Elixophylline. Theophylline serum concentration in the postabsorptive phase declined in a monoexponential manner. Total body clearance, elimination half-lif...

journal_title：Gerontology

authors： Blouin RA,Erwin WG,Foster TS,Scott S

更新日期：1982-01-01 00:00:00

abstract：:Aging is associated with a decline in renal concentrating ability in response to dehydration-induced arginine vasopressin (AVP) release. To examine target tissue sensitivity, cortical collecting tubules (CCT) were individually microdissected from young (3 months), middle-aged (2-3 years) and old (4-5.5 years) rabbits ...

journal_title：Gerontology

authors： Wilson PD,Dillingham MA

更新日期：1992-01-01 00:00:00

abstract：:Hydrogen breath testing (HBT) is frequently used as an alternative to small bowel aspiration in the diagnosis of small intestinal bacterial overgrowth (SIBO). The role of the glucose HBT was assessed in 30 elderly patients. A positive HBT was recorded in 15 of 20 SIBO cases and 7 of 10 culture negatives (sensitivity 7...

journal_title：Gerontology

authors： Mac Mahon M,Gibbons N,Mullins E,O'Moore RR,Keane CT,Walsh JB,Coakley D

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:compared with other vertebrate taxa, mammals possess a very limited capacity for appendage regeneration. The antlers of deer are an exception in that they are periodically lost and fully regenerated throughout the life of an individual. OBJECTIVE:in this paper we compare certain aspects of antler regenerati...

journal_title：Gerontology

authors： Kierdorf U,Kierdorf H

更新日期：2011-01-01 00:00:00

abstract：:The immunocompetence of 22 subjects aged 85-104 years (mean 90 +/- 1 years) was studied and compared to 21 young subjects aged 19-37 years (mean 30 +/- 1 years). The absolute lymphocyte number and the percentage of T and B lymphocytes in the peripheral blood was similar in the two groups. A marked decrease in phytohem...

journal_title：Gerontology

authors： Licastro F,Tabacchi PL,Chiricolo M,Parente R,Cenci M,Barboni F,Franceschi C

更新日期：1983-01-01 00:00:00

abstract：:We quantitated the skin elastic fibers of the papillary and reticular dermis using specific staining procedure followed by automated computerized image analysis. Fifty skin biopsies of patients consulting for cardiovascular risk factors were studied. The following parameters were estimated: surface area (% of total su...

journal_title：Gerontology

authors： Robert C,Lesty C,Robert AM

更新日期：1988-01-01 00:00:00

abstract：:Age differences in decision-making are of theoretical interest and have important practical implications, but relevant lines of work are distributed across multiple disciplines and often lack integration. The present review proposes an overarching conceptual framework with the aim of connecting disjointed aspects of t...

journal_title：Gerontology

authors： Löckenhoff CE

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:A large proportion of falls in older people are caused by slipping. Previous occupational safety research suggests that inadequate footwear may contribute to slipping accidents; however, no studies have assessed the slip resistance of casual footwear. OBJECTIVE:To evaluate the slip resistance of different t...

journal_title：Gerontology

authors： Menz HB,Lord ST,McIntosh AS

更新日期：2001-05-01 00:00:00

abstract：:To determine the influence of age, disease and other factors on anthropometric indices in elderly subjects aged 70 years and above, body mass index (BMI), arm muscle circumference (AMC), corrected arm muscle area (CAMA), fat-free mass (FFM) and total body fat (TBF) were determined in a random sample of 990 Chinese men...

journal_title：Gerontology

authors： Woo J,Ho SC,Sham A,Yuen YK,Chan SG

更新日期：1995-01-01 00:00:00

abstract：AIM:To investigate acceptance and usage issues in relation to Telehealth products as used by frail older clients of the Transition Care Program and their carers. METHOD:The study design was a quasi-randomised controlled clinical trial. A stratified random sample of participants was allocated to one of five groups usin...

journal_title：Gerontology

authors： Wade R,Shaw K,Cartwright C

更新日期：2012-01-01 00:00:00

abstract：:A prospective study of post-operative morbidity in 258 elderly general surgical patients is reported. In 35% of patients no post-operative complications developed. Respiratory, wound and cardiac complications were the leading types of post-operative morbidity encountered, occurring in 39.5, 16.3, and 12.4% of patients...

journal_title：Gerontology

authors： Seymour DG,Pringle R

更新日期：1983-01-01 00:00:00

abstract：:The article discusses some aspects demonstrating that a decrease in acetylcholine synthesis in senile dementia of the Alzheimer type (SDAT) is a consequence of the strong decline in glucose turnover in the brain. This becomes obvious by the fact that acetylcoenzyme A, the key substrate of acetylcholine synthesis, is e...

journal_title：Gerontology

authors： Meier-Ruge W,Bertoni-Freddari C,Iwangoff P

更新日期：1994-01-01 00:00:00

abstract：:The Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or ...

journal_title：Gerontology

authors： Savino W,Messias CV,Mendes-da-Cruz DA,Passos P,Ferreira AC,Nascimento OJ

更新日期：2017-01-01 00:00:00

abstract：:In mammals, aging is often viewed as a progressive decline in physiological competence with a corresponding inability to adapt to stressful stimulation. Several current theories of aging have implicated the sympathetic nervous system in many of the metabolic, cardiovascular and behavior changes which attend advancing ...

journal_title：Gerontology

authors： McCarty R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:During development and aging, as well as under hypoxia, many cells can adapt to a stressful environment, while others are damaged and die by apoptosis. In particular, intermittent hypoxia, i.e., hypoxia followed by reoxygenation, determines different responses in young and adult myocardia. OBJECTIVE:In the ...

journal_title：Gerontology

authors： Bianchi G,Di Giulio C,Rapino C,Rapino M,Antonucci A,Cataldi A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Older adults are stereotypically considered to be risk averse compared to younger age groups, although meta-analyses on age and the influence of gain/loss framing on risky choices have not found empirical evidence for age differences in risk-taking. OBJECTIVE:The current study extends the investigation of a...

journal_title：Gerontology

authors： Best R,Freund AM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Moderate physical exercise, dietary restriction as well as enriched environment in separate studies have been reported to delay some of the adverse effects of aging on brain function, parallel to an increase in brain-derived neurotrophic factor (BDNF). In order to elucidate these influences in a com...

journal_title：Gerontology

authors： Strasser A,Skalicky M,Hansalik M,Viidik A

更新日期：2006-01-01 00:00:00

abstract：:The life span of Drosophila melanogaster was reduced when copper compounds were fed at concentrations of 1 X 10(-3) M or greater. Feeding lower concentrations of copper compounds failed to significantly change life span. A combination of copper gluconate and gluconic acid increased the adult life span by 21.6%. We con...

journal_title：Gerontology

authors： Massie HR,Williams TR,Aiello VR

更新日期：1984-01-01 00:00:00

abstract：:The effects of ovine corticotropin releasing factor (o-CRF) on the secretions of ACTH, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were studied in the healthy young and elderly male individuals. o-CRF caused significant elevations of plasma ACTH, cortisol and DHEA concentrations...

journal_title：Gerontology

authors： Ohashi M,Fujio N,Kato K,Nawata H,Ibayashi H

更新日期：1986-01-01 00:00:00