Basal synthesis of heat shock protein 70 increases with age in rat kidneys.

abstract：:(Na+-K+)-ATPase is an enzyme responsible for ionic homeostasis in excitable tissues. Thus, the activity of this enzyme is essential for the maintenance of optimal function of the cerebral cortex. Although abnormalities of cerebral oxidative metabolism have been described in aging, these abnormalities do not appear to ...

journal_title：Gerontology

authors： LaManna JC,Doull G,McCracken K,Harik SI

更新日期：1983-01-01 00:00:00

abstract：:The age-related accumulation of lipopigments was determined in the adrenergic and nonadrenergic peripheral neurons of the rat using a microspectrofluorometric method and electron microscopy, 3-, 12- and 30-month-old rats were used. The rate of lipopigment accumulation was greater in nonadrenergic than adrenergic neuro...

journal_title：Gerontology

authors： Koistinaho J

更新日期：1986-01-01 00:00:00

abstract：:During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...

journal_title：Gerontology

authors： Moran D,Korzets Z,Bernheim J,Bernheim J,Yaretzky A

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Historically, older adults have been disproportionately affected by disasters. In particular, homebound adults are especially at risk. As one facet of bolstering community resilience, home health agencies have been tasked with improving their patients' disaster preparedness. However, home health practitioner...

journal_title：Gerontology

authors： Wyte-Lake T,Claver M,Tubbesing S,Davis D,Dobalian A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease ...

journal_title：Gerontology

authors： Barnett BP,Handa JT

更新日期：2013-01-01 00:00:00

abstract：:L-tryptophan (L-T) was added at a dose of 150-450 mg daily to eight Parkinsonian patients who developed visual hallucinations with paranoidal features under L-dopa (L-D) treatment (112.5-75 mg daily) in combination with alpha-methyldopa hydrazine (12.5-75 mg daily). In six patients L-T ameliorated the symptomatology b...

journal_title：Gerontology

authors： Rabey JM,Vardi J,Askenazi JJ,Streifler M

更新日期：1977-01-01 00:00:00

abstract：:Alteration in lipid peroxidation products such as lipid peroxides, lipid hydroperoxides were studied in different regions of CNS of ageing rats (13, 26, 52, 78 and 104 weeks). The levels of lipid peroxide and lipid hydroperoxide were increased in various regions of brain and spinal cord. However, the activity of super...

journal_title：Gerontology

authors： Gupta A,Hasan M,Chander R,Kapoor NK

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Disturbance of vertical eye movement and ocular convergence is often observed in elderly people, but little is known about its frequency. OBJECTIVE:The purpose of this study was to investigate age-associated changes in vertical eye movement and convergence in healthy elderly people, using a digital video ca...

journal_title：Gerontology

authors： Oguro H,Okada K,Suyama N,Yamashita K,Yamaguchi S,Kobayashi S

更新日期：2004-05-01 00:00:00

abstract：:The maximal glucocorticoid responsiveness and the adaptation degree are reduced in old rat liver as demonstrated by cortisol stimulation of RNA polymerases. Nevertheless the concentration of unoccupied 3H-dexamethasone binding sites in molybdate-stabilized cytosol of adrenalectomized old animals is significantly incre...

journal_title：Gerontology

authors： Martin H,Martin R

更新日期：1988-01-01 00:00:00

abstract：:The interactions of ergot alkaloids and of other drugs with dopamine (DA) and alpha-adrenergic receptors were investigated. The tested ergot alkaloids inhibit synaptosomal tyrosine hydroxylase activity and reverse the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Thus, ergot alkaloids ...

journal_title：Gerontology

authors： Goldstein M,Lew JY,Hata F,Lieberman A

更新日期：1978-01-01 00:00:00

abstract：:We use nerve tissue cultures as a model system for studying the mode of action of centrally acting drugs. Neurons in cerebellar cultures retain a number of organ-specific properties including the formation of complex synaptic networks and characteristic bioelectric activity. Electrical activity may be recorded from Pu...

journal_title：Gerontology

authors： Gähwiler BH

更新日期：1978-01-01 00:00:00

abstract：INTRODUCTION:The identification of modifiable health span-promoting factors is a public health priority. OBJECTIVE:To explore the socio-environmental, lifestyle, behavioural, and psychological determinants of a clinical phenotypic measure of biological ageing in the Singapore Longitudinal Ageing Study (SLAS) cohort. ...

journal_title：Gerontology

authors： Ng TP,Zhong X,Gao Q,Gwee X,Chua DQL,Larbi A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The link between longevity and diet is of great interest to biological and gerontological research. The fact that relevant knowledge has generally been available for many centuries is often not remarked upon. OBJECTIVE:This article examines three aspects of early modern Western medicine which thematize the ...

journal_title：Gerontology

authors： Schafer D

更新日期：2005-03-01 00:00:00

abstract：:The rates of collagen fibril formation are, under otherwise identical conditions, a function of the age of the acid-soluble rat tail tendon collagen utilized. The rate is most rapid with young adult (165 day) collagen, which exhibits no induction period before collagen multimerization begins. In contrast, 21-day colla...

journal_title：Gerontology

authors： Brooks C,Simons ER

更新日期：1978-01-01 00:00:00

abstract：:Morphometric measurements have been carried out on the human myenteric esophageal neurons at the ages of 20-40 and more than 70 years. The number of neurons decreases after 70 years of age, which is accompanied by an increase in the sizes of the neurons. In percentage terms the decrease in the number of neurons in the...

journal_title：Gerontology

authors： Meciano Filho J,Carvalho VC,de Souza RR

更新日期：1995-01-01 00:00:00

abstract：:Phagocytically stimulated canine leukocyte suspensions obtained from 12 young adult and 43 aged individuals were examined for several physiological manifestations of the phagocytically induced respiratory burst. There was considerable variation in levels of oxygen consumption, glucose oxidation via the hexose monophos...

journal_title：Gerontology

authors： Johnson DD,Renshaw HW,Warner DH,Browder EJ,Williams JD

更新日期：1984-01-01 00:00:00

abstract：:Electrolytes and/or amino acids were determined in leg skeletal muscle biopsies from elderly (age range 57-75 years) and young (age range 20-35 years) apparently healthy women. When compared to the young group, the elderly one was characterized by increased levels of muscular Na+ and Cl-, while the calculated intracel...

journal_title：Gerontology

authors： Möller P,Alvestrand A,Bergström J,Fürst P,Hellström K

更新日期：1983-01-01 00:00:00

abstract：:Protein malnutrition is associated with a decreased febrile and acute phase response to infection and increased mortality. To elucidate a cause for this poor response, we assessed the effect of chronic protein malnutrition on monocyte production of the pyrogens interleukin-1 (IL-1) and tumor necrosis factor (TNF). Thi...

journal_title：Gerontology

authors： Bradley SF,Vibhagool A,Fabrick S,Terpenning MS,Kauffman CA

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Many falls in older adults occur during walking and result in lateral falls. The ability to perform a recovery step after balance perturbation determines whether a fall will occur. AIM:To investigate age-related changes in first recovery step kinematics and kinematic adaptations over a wide range of later...

journal_title：Gerontology

authors： Nachmani H,Shani G,Shapiro A,Melzer I

更新日期：2020-01-01 00:00:00

abstract：:100 consecutive endoscopies in elderly patients referred with symptoms after previous gastric surgery are reviewed. 57% showed positive findings, and the procedure was found particularly useful in making definitive diagnoses in patients presenting with dyspepsia and upper gastro-intestinal bleeding. The incidence of g...

journal_title：Gerontology

authors： Gibbins FJ,Gupta SD,Sen I

更新日期：1985-01-01 00:00:00

abstract：:The concentration of malonaldehyde (MDA) was measured in human erythrocytes obtained from subjects suffering from senile dementia of the Alzheimer type (SDAT), non-demented elderly subjects, and from young controls by two methods: high-performance liquid chromatography (HPLC) and the thiobarbituric acid (TBA) test. Th...

journal_title：Gerontology

authors： Bermejo P,Gómez-Serranillos P,Santos J,Pastor E,Gil P,Martín-Aragón S

更新日期：1997-01-01 00:00:00

abstract：:The Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or ...

journal_title：Gerontology

authors： Savino W,Messias CV,Mendes-da-Cruz DA,Passos P,Ferreira AC,Nascimento OJ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Aging changes in different body system are well described, but few studies have considered the relationship between them. OBJECTIVE:The purpose of this study was, therefore, to investigate the interrelationships between markers of aging in different parts of the body. METHODS:A cross-sectional study design...

journal_title：Gerontology

authors： Aihie Sayer A,Osmond C,Briggs R,Cooper C

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:compared with other vertebrate taxa, mammals possess a very limited capacity for appendage regeneration. The antlers of deer are an exception in that they are periodically lost and fully regenerated throughout the life of an individual. OBJECTIVE:in this paper we compare certain aspects of antler regenerati...

journal_title：Gerontology

authors： Kierdorf U,Kierdorf H

更新日期：2011-01-01 00:00:00

abstract：:Tuberculosis is still a major cause of morbidity and mortality worldwide. Recent studies have suggested that even in the developed world its incidence in the elderly is increasing. Symptoms of active tuberculosis are non-specific and less pronounced in the elderly. Radiological features are more likely to be 'atypical...

journal_title：Gerontology

authors： Packham S

更新日期：2001-07-01 00:00:00

abstract：:Normal circulating red blood cells (RBCs) and platelets have been shown to have small amounts of IgG on their membranes. The cell-bound IgG may be cytophilic (IgG nonspecifically adsorbed from the plasma) and/or IgG autoantibody. It has been suggested that most of the RBC-bound IgG is on older RBCs and is an autoantib...

journal_title：Gerontology

authors： Garratty G

更新日期：1991-01-01 00:00:00

abstract：:To develop a new method for accurately predicting creatinine clearance (Ccr) in the debilitated elderly without urine collections, the total muscle volume of both thighs (MV thigh), as a new predictive parameter, was calculated using computed tomography in 68 debilitated patients aged 61-92 years. A regression line be...

journal_title：Gerontology

authors： Sanaka M,Takano K,Shimakura K,Koike Y,Mineshita S

更新日期：1995-01-01 00:00:00

abstract：:Historically, family ties have been understood as the primary source of support for aging adults, and past empirical and theoretical work has highlighted the tendency of older adults to focus on close family. However, in line with demographic changes and historical increases in the diversity of social structures, frie...

journal_title：Gerontology

authors： Fiori KL,Windsor TD,Huxhold O

更新日期：2020-01-01 00:00:00

abstract：:The effect of ageing on the threshold firing rate of motor units from the first dorsal interosseous muscle was investigated. Two groups of 9 healthy male subjects between the ages of 20-29 and 60-69 years took part in the study. The threshold firing rate of motor units in young subjects showed close agreement with pre...

journal_title：Gerontology

authors： Newton JP,Yemm R,McDonagh MJ

更新日期：1988-01-01 00:00:00

abstract：:During a winter epidemic of A/H1N1 influenza virus, we evaluated the protection conferred by vaccination of 285 residents of a nursing home. Fifteen of 204 members of the nursing staff were also vaccinated. Serological determinations were performed before and after vaccination using radial hemolysis (RH) and neuramini...

journal_title：Gerontology

authors： Odelin MF,Pozzetto B,Aymard M,Defayolle M,Jolly-Million J

更新日期：1993-01-01 00:00:00