Rapid and accurate estimation of creatinine clearance in the muscle-wasted elderly by computed tomography.

Abstract:

:To develop a new method for accurately predicting creatinine clearance (Ccr) in the debilitated elderly without urine collections, the total muscle volume of both thighs (MV thigh), as a new predictive parameter, was calculated using computed tomography in 68 debilitated patients aged 61-92 years. A regression line between 24-hour urinary creatinine excretion and MV thigh was divided by serum creatinine (Scr), and then the following formula was derived: Ccr (ml/min) = 9 x [MV thigh (cm3) - 100]/[1,000 x Scr (mg/dl)] Predicted Ccr by the new method more closely correlated with measured Ccr (r = 0.862) than did predicted Ccr by Cockcroft and Gault's method (the C-G method) (r = 0.727). Statistical analysis of prediction error (= predicted Ccr-measured Ccr) suggested that the new method could provide more accurate and less biased estimations of Ccr than did the C-G method, even in patients with renal insufficiency. By using computed tomography, we have proposed a more accurate method for predicting Ccr of the debilitated elderly than the C-G method, although the new method has inherent disadvantages of radiation exposure and high cost.

journal_name

Gerontology

journal_title

Gerontology

authors

Sanaka M,Takano K,Shimakura K,Koike Y,Mineshita S

doi

10.1159/000213705

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

332-42

issue

6

eissn

0304-324X

issn

1423-0003

journal_volume

41

pub_type

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