Abstract:
:To develop a new method for accurately predicting creatinine clearance (Ccr) in the debilitated elderly without urine collections, the total muscle volume of both thighs (MV thigh), as a new predictive parameter, was calculated using computed tomography in 68 debilitated patients aged 61-92 years. A regression line between 24-hour urinary creatinine excretion and MV thigh was divided by serum creatinine (Scr), and then the following formula was derived: Ccr (ml/min) = 9 x [MV thigh (cm3) - 100]/[1,000 x Scr (mg/dl)] Predicted Ccr by the new method more closely correlated with measured Ccr (r = 0.862) than did predicted Ccr by Cockcroft and Gault's method (the C-G method) (r = 0.727). Statistical analysis of prediction error (= predicted Ccr-measured Ccr) suggested that the new method could provide more accurate and less biased estimations of Ccr than did the C-G method, even in patients with renal insufficiency. By using computed tomography, we have proposed a more accurate method for predicting Ccr of the debilitated elderly than the C-G method, although the new method has inherent disadvantages of radiation exposure and high cost.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Sanaka M,Takano K,Shimakura K,Koike Y,Mineshita Sdoi
10.1159/000213705subject
Has Abstractpub_date
1995-01-01 00:00:00pages
332-42issue
6eissn
0304-324Xissn
1423-0003journal_volume
41pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract::The effect of age on the compositional analysis of human Descemet's membrane was examined. Membranes were obtained from human corneas ranging from 0.5 to 95 years and purified by sodium dodecyl sulfate (SDS) extraction. Substantial age-related changes were obtained in the amino acid compositions of the SDS-insoluble b...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212417
更新日期:1980-01-01 00:00:00
abstract::Anion exchange (AE) proteins are present in human neurons in the brain. Immunohistochemical data indicate that their apparent expression level increases with age, and especially with degeneration in Alzheimer's disease-affected brain areas. The increase in immunoreactivity is probably caused by changes in AE structure...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213836
更新日期:1997-01-01 00:00:00
abstract::Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212507
更新日期:1982-01-01 00:00:00
abstract::(Na+-K+)-ATPase is an enzyme responsible for ionic homeostasis in excitable tissues. Thus, the activity of this enzyme is essential for the maintenance of optimal function of the cerebral cortex. Although abnormalities of cerebral oxidative metabolism have been described in aging, these abnormalities do not appear to ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213123
更新日期:1983-01-01 00:00:00
abstract::Various parameters of copulatory behavior were examined in intact and castrated testosterone-(T-)treated male rats of various ages ranging from 3 to 27 months. Serum T levels were controlled by subcutaneous implantation of different sizes of T-filled Silastic capsules at the time of castration. In intact male rats, sc...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212760
更新日期:1986-01-01 00:00:00
abstract::The interactions of ergot alkaloids and of other drugs with dopamine (DA) and alpha-adrenergic receptors were investigated. The tested ergot alkaloids inhibit synaptosomal tyrosine hydroxylase activity and reverse the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Thus, ergot alkaloids ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212301
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Developmental researchers use a variety of research designs to examine aging-related changes. Most longitudinal studies of aging are based on research designs that feature successive, widely spaced, assessments to estimate changes in cognitive performance. Such designs assume that short-term variations in co...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000074382
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:While many studies investigate the factors that influence the institutionalisation of older persons, only a few consider one of its most important predictors, namely, the perceived need for institutionalisation. Also referred to as 'desire for institutionalisation', it has mainly been investigated for inform...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000131887
更新日期:2008-01-01 00:00:00
abstract::Older adults often face challenges as they transition out of the acute care hospital, especially with regard to adhering to their medications. In this narrative review, we discuss medication adherence in older adults across the continuum of care, describing reasons for nonadherence, methods to assess adherence and too...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000363765
更新日期:2015-01-01 00:00:00
abstract::We performed 24-hour ambulatory electrocardiographic (Holter) examinations in 50 retired hospital workers (30 men, 20 women), aged 58-85 years (mean age +/- SD: 65.9 +/- 4.6 years), with a normal clinical history, physical examination and baseline ECG. There was a significant difference between daytime and nocturnal m...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213015
更新日期:1989-01-01 00:00:00
abstract::The pharmacokinetics of indomethacin (Indo) was studied in 10 healthy elderly male volunteers (age 67-81 years) following the oral administration of a single 75-mg dose of a sustained release form of Indo. The total and free plasma and erythrocyte concentrations of Indo were determined by a specific high-pressure liqu...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212802
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Health care providers often believe that individuals with cognitive disturbance are unaware of their deficits. The term unawareness was first used to describe hemiplegia following right hemisphere stroke but has since been applied to unawareness of any neurological or neuropsychological deficit. Clinicians u...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022027
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:In Japan, vascular dementia (VD) has been responsible for the majority of all dementia cases in both epidemiological and neuropathological studies. Recently, however, several epidemiological investigations have shown that the rate of VD has decreased and senile dementia of the Alzheimer type (SDAT) is now th...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022054
更新日期:1999-01-01 00:00:00
abstract::As populations age globally, the health of older adults is looming larger on the agendas of public health bodies. In particular, the priority is to ensure that older adults remain healthy, independent, and engaged in their communities. In other words, ensuring that increasing life spans are matched by increasing "heal...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000503141
更新日期:2020-01-01 00:00:00
abstract::The effects of ovine corticotropin releasing factor (o-CRF) on the secretions of ACTH, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were studied in the healthy young and elderly male individuals. o-CRF caused significant elevations of plasma ACTH, cortisol and DHEA concentrations...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212812
更新日期:1986-01-01 00:00:00
abstract::Cell surface of chick fibroblasts were labelled by a short treatment with 125I in presence of lactoperoxidase. A glycoprotein (220,000 molec. wt) was iodinated and was present in a more exposed position or in greater amounts at the surface of old phase III cells compared to young phase II cells. The findings extend ou...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212149
更新日期:1976-01-01 00:00:00
abstract::The 'use it or lose it' hypothesis of cognitive aging predicts that engagement in intellectual, social, and physical activities offers protective benefits from age-related cognitive decline and lowers dementia risk. Although this hypothesis has not yet been supported conclusively, there is some empirical evidence in f...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000264918
更新日期:2010-01-01 00:00:00
abstract::A retrospective study was made of 50 consecutive cases of bacteraemia treated in a geriatric unit. The mortality rate was 24%, the highest incidence occurring amongst the cases of hospital-acquired bacteraemia where only 1 of 7 cases survived the infection. Pyrexia, acute confusion, and falls were the commonest presen...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213104
更新日期:1983-01-01 00:00:00
abstract::Aging researchers have long been interested in understanding individuals' subjective perceptions of their own memory functioning. Previous research has shown that subjective memory ratings are partly based on memory performance but also reflect the influence of other factors, such as depressive symptoms. The aim of th...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000369010
更新日期:2015-01-01 00:00:00
abstract::The immunocompetence of 22 subjects aged 85-104 years (mean 90 +/- 1 years) was studied and compared to 21 young subjects aged 19-37 years (mean 30 +/- 1 years). The absolute lymphocyte number and the percentage of T and B lymphocytes in the peripheral blood was similar in the two groups. A marked decrease in phytohem...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213095
更新日期:1983-01-01 00:00:00
abstract::During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213514
更新日期:1993-01-01 00:00:00
abstract::Hydrogen breath testing (HBT) is frequently used as an alternative to small bowel aspiration in the diagnosis of small intestinal bacterial overgrowth (SIBO). The role of the glucose HBT was assessed in 30 elderly patients. A positive HBT was recorded in 15 of 20 SIBO cases and 7 of 10 culture negatives (sensitivity 7...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213769
更新日期:1996-01-01 00:00:00
abstract::We quantitated the skin elastic fibers of the papillary and reticular dermis using specific staining procedure followed by automated computerized image analysis. Fifty skin biopsies of patients consulting for cardiovascular risk factors were studied. The following parameters were estimated: surface area (% of total su...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212969
更新日期:1988-01-01 00:00:00
abstract::Although the two-point discrimination test of the skin is a simple test of the sensory nerve function, there have been few studies on age-related changes in the ability to discriminate between two points in a large noninstitutionalized population. In this study we attempted (1) to determine normal values on the two-po...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213693
更新日期:1995-01-01 00:00:00
abstract::The last 2 decades have brought an explosion of research, new products, and general attention to the problem of urinary urgency, and yet patients continue to be plagued by this symptom - especially the elderly. What is it? What does it mean? How can we guide patients successfully through this challenge? This paper pre...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000492330
更新日期:2018-01-01 00:00:00
abstract::Dietary intake, sunlight exposure and 25-hydroxy-vitamin D levels were estimated in 62 patients admitted to a geriatric assessment unit. There was a significant correlation between vitamin D intake and 25-hydroxy-vitamin D levels but none between sunlight exposure and these. This suggests that in old age dietary defic...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212244
更新日期:1978-01-01 00:00:00
abstract::Lymphopenia is a common finding in old people admitted to medical and psychiatric wards. We describe a pilot study of the clinical associations, and prognostic significance of lymphopenia in elderly persons admitted to acute medical and psychiatric wards. Consecutive patients admitted to acute medical and psychiatric ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022003
更新日期:1998-01-01 00:00:00
abstract::Constant exposure to new and persisting antigens and the need to replace cellular attrition with newly built cells lead to profound remodeling of the immune system after the age of 50 years. The impact of the immunosenescence process varies amongst the different cellular subsets represented within the immune system. E...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000355303
更新日期:2014-01-01 00:00:00
abstract::Age differences in decision-making are of theoretical interest and have important practical implications, but relevant lines of work are distributed across multiple disciplines and often lack integration. The present review proposes an overarching conceptual framework with the aim of connecting disjointed aspects of t...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000485247
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Falls are a major cause of morbidity among older people. Multifaceted interventions may be effective in preventing falls and related fractures. OBJECTIVE:To evaluate the cost-effectiveness alongside the REducing Falls with Orthoses and a Multifaceted podiatry intervention (REFORM) trial. METHODS:REFORM was...
journal_title:Gerontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000489171
更新日期:2018-01-01 00:00:00