Abstract:
:In mammals, aging is often viewed as a progressive decline in physiological competence with a corresponding inability to adapt to stressful stimulation. Several current theories of aging have implicated the sympathetic nervous system in many of the metabolic, cardiovascular and behavior changes which attend advancing age. To provide an empirical base for evaluating the role of the sympathetic nervous system in aging, I have studied the activity of the sympathetic nerves and the adrenal medulla of adult and aged Fischer 344 male rats before, during and after exposure to various stressful stimuli. Plasma levels of norepinephrine and epinephrine served as biochemical indices of the activity of the sympathetic nerves and the adrenal medulla, respectively. Under resting conditions, rats 4-24 months of age had similar plasma levels of both catecholamines. When stressed for a brief period of time (intermittent footshock for 1 min), 12- and 24-month-old rats exhibited a diminished sympathetic-adrenal medullary response compared to young adult rats (4 months old). With an increase in the intensity and duration of the stressor (cold water immersion for 10 min), the sympathetic-adrenal medullary responses of 6- and 22-month-old rats were comparable. However, the sympathetic nervous system remained in a heightened state of activity for a longer period of time following the stressful stimulus in aged rats. Finally, with prolonged exposure to an intense stressor (cellular glucoprivation following administration of 2-deoxy-D-glucose), 24-month-old rats exhibited an exaggerated adrenal medullary response and a greater mortality rate compared to 6-month-old rats. These findings suggest that homeostatic regulation of the sympathetic nervous system is impaired in aged rodents. Further, the nature of this impairment is dependent upon the intensity and duration of the activating stimulus. These apparent age-related alterations in regulation of the sympathetic nervous system may contribute to the increased morbidity and mortality of aged animals during prolonged exposure to stressful stimulation.
journal_name
Gerontologyjournal_title
Gerontologyauthors
McCarty Rdoi
10.1159/000212785subject
Has Abstractpub_date
1986-01-01 00:00:00pages
172-83issue
3eissn
0304-324Xissn
1423-0003journal_volume
32pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract::Demented elderly patients unable to eat independently and often refusing food are threatened by malnutrition. Therefore, we determined in 6 female patients aged 74-100 with senile dementia the average daily food consumption within a 3-week period by the exact weighing methods on six occasions. The average daily energy...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213107
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:It has been proposed that active engagement with life may protect against cognitive decline. However, existing instruments for measuring life engagement have covered limited domains. OBJECTIVE:To present a new instrument to measure engagement with life; the RIASEC Activities List draws on activities categor...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000091829
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Mild-to-moderate chronic kidney disease (CKD G3a) is prevalent in older adults. Substantial evidence suggests that individuals with advanced CKD face a high risk for common geriatric conditions, like functional impairment and cognitive decline, whereas the relationships between mild-to-moderate CKD and funct...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000484140
更新日期:2018-01-01 00:00:00
abstract::When mouse peritoneal macrophages were cultured with oxidized human low density lipoprotein (ox-LDL), storage of ceroid-like pigments was observed within the cells by light and fluorescent microscopy, and fluorescence spectrophotometry. The fluorescent products exhibit the characteristics of Schiff base structures, ha...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213724
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Irrelevant unexpected stimuli elicit various types of inhibitory processes modulated by ongoing activity. An index of the inhibitory processes, namely the N2b and P3a event-related potentials (ERP), shows marked age-related differences. OBJECTIVE:In this experiment, we attempted to separate the effects of i...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000314159
更新日期:2011-01-01 00:00:00
abstract::Electrolytes and/or amino acids were determined in leg skeletal muscle biopsies from elderly (age range 57-75 years) and young (age range 20-35 years) apparently healthy women. When compared to the young group, the elderly one was characterized by increased levels of muscular Na+ and Cl-, while the calculated intracel...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213088
更新日期:1983-01-01 00:00:00
abstract::Although the two-point discrimination test of the skin is a simple test of the sensory nerve function, there have been few studies on age-related changes in the ability to discriminate between two points in a large noninstitutionalized population. In this study we attempted (1) to determine normal values on the two-po...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213693
更新日期:1995-01-01 00:00:00
abstract::The effect of aging on plasma erythropoietin (EPO) levels after acute hemorrhage was investigated in ovariectomized (Ovx) rats. Old (22 months), middle (mid)-aged (14 months) and adult (5-6 months) Ovx rats were studied. Rats were anesthetized with ether and bled by heart puncture (5 ml/kg). They were bled again after...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213666
更新日期:1995-01-01 00:00:00
abstract::The objective of this work was to study patients' self-appraisal of total knee arthroplasty (TKA) 6 and 12 months postoperatively, and to establish which factors determine dissatisfaction from surgery. The study group consisted of 79 patients subjected to TKA who underwent rehabilitation in a specialized institution f...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022011
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Falls are a significant problem for older adults. Individuals who have sustained a fall come to the attention of health care providers and are at risk of further falls. To promote the highest quality of care and reduce variation in care, a practice guideline is needed. Summarization of evidence regarding fal...
journal_title:Gerontology
pub_type: 杂志文章,meta分析
doi:10.1159/000067948
更新日期:2003-03-01 00:00:00
abstract::Protein malnutrition is associated with a decreased febrile and acute phase response to infection and increased mortality. To elucidate a cause for this poor response, we assessed the effect of chronic protein malnutrition on monocyte production of the pyrogens interleukin-1 (IL-1) and tumor necrosis factor (TNF). Thi...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213193
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:Age-related functional decline elevates the risk of car accidents. Whether specific cognitive impairments and physical frailty increase the risk of car accidents is still unclarified. OBJECTIVE:This study examines the association between car accidents, frailty, and cognitive function, owing to an increase...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000508823
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:BACKGROUND; The link between experiencing difficulties in reading or understanding and non-compliance with drug treatment among seniors is not clearly established. OBJECTIVES:We measured the effect of both difficulties in reading, as well as difficulties in understanding prescription labelling, on non-compl...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000048924
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Early emergency readmissions is a common and important problem in the elderly patient. Identification of the risk factors for early emergency readmissions is needed to prevent this occurring. OBJECTIVE:The aim of this study was to study the risk factors for early emergency readmission in the elderly medical...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022091
更新日期:1999-07-01 00:00:00
abstract::The article discusses some aspects demonstrating that a decrease in acetylcholine synthesis in senile dementia of the Alzheimer type (SDAT) is a consequence of the strong decline in glucose turnover in the brain. This becomes obvious by the fact that acetylcoenzyme A, the key substrate of acetylcholine synthesis, is e...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000213592
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Understanding comorbidity prevalence and the effects of comorbidities in older veterans with lower extremity amputations may aid in assessing patient outcomes, resource use, and facility-level quality of care. OBJECTIVES:To determine the degree to which adding outpatient to inpatient administrative data sou...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000101703
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Werner's syndrome, a rare autosomal recessive disorder, is characterized by features of premature aging. Seventy-five percent of the alleles of Japanese patients with Werner's syndrome have one of three major mutations. OBJECTIVE:To determine the genotype of a patient with Werner's syndrome. METHODS:We dia...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000058353
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Research on the relationship between vestibular function and falls in older people is sparse. The perception of the postural vertical (PPV) provides an indicator measure of vestibular (otolith) function in the absence of visual input and diminished somatosensory feedback. OBJECTIVE:This study examined wheth...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000339295
更新日期:2012-01-01 00:00:00
abstract::Morphometric measurements have been carried out on the human myenteric esophageal neurons at the ages of 20-40 and more than 70 years. The number of neurons decreases after 70 years of age, which is accompanied by an increase in the sizes of the neurons. In percentage terms the decrease in the number of neurons in the...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213658
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:A large proportion of falls in older people are caused by slipping. Previous occupational safety research suggests that inadequate footwear may contribute to slipping accidents; however, no studies have assessed the slip resistance of casual footwear. OBJECTIVE:To evaluate the slip resistance of different t...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000052788
更新日期:2001-05-01 00:00:00
abstract::Induced tyrosine aminotransferase from adult and old rat liver was purified and its properties were studied. No differences could be detected for any physicochemical properties studied, i.e. specific activity, molecular weight, isoelectric point, thermostability, sensitivity to trypsin, Km for pyridoxal phosphate. Mor...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213132
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVES:Due to an increase in the percentage of older people in industrialized countries there is an increasing demand for medical care for the elderly. With advancing age, a series of structural, architectural and compositional modifications take place in the vasculature. Therefore, we analyzed the influence of pat...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000080177
更新日期:2004-11-01 00:00:00
abstract::The pharmacokinetics of indomethacin (Indo) was studied in 10 healthy elderly male volunteers (age 67-81 years) following the oral administration of a single 75-mg dose of a sustained release form of Indo. The total and free plasma and erythrocyte concentrations of Indo were determined by a specific high-pressure liqu...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212802
更新日期:1986-01-01 00:00:00
abstract::Dysfunction associated with the aging process positions aging as a leading culprit for development of devastating diseases and mounting health-care costs. Many age-associated conditions for which aging increases risk are neurological disorders with no effective treatments, including Alzhei-mer's disease. As the propor...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000492573
更新日期:2019-01-01 00:00:00
abstract::This review focuses on 3 allergic disorders of persons coming up against venerable age: asthma, allergic rhinitis, and atopic dermatitis. The prevalence of allergic diseases in the elderly ranges from 5 to 10% and appears to be rising. A gradual decline in immune function, termed immunosenescence, and age-related chan...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000355307
更新日期:2014-01-01 00:00:00
abstract::Phagocytically stimulated canine leukocyte suspensions obtained from 12 young adult and 43 aged individuals were examined for several physiological manifestations of the phagocytically induced respiratory burst. There was considerable variation in levels of oxygen consumption, glucose oxidation via the hexose monophos...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212625
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Hearing impairment (HI) is a very common condition in elderly people and the epidemiology together with hearing-related problems is still poorly investigated. Moreover, the cognitive status may be impaired in relation to hearing function. OBJECTIVE:The goal of the study was to evaluate: (a) the prevalence o...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022113
更新日期:1999-11-01 00:00:00
abstract::The aim of the study was to examine the characteristics of colorectal cancer in elderly patients. The medical histories of 178 consecutive patients (79 men and 99 women) with colorectal cancer were studied from hospital records. The studied parameters were compared between three age groups: under 65 years old, 65-80 y...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213537
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Each year, influenza and its complications account for 10,000-40,000 excess deaths in the United States. Over 80% of these deaths occur among the elderly. The Advisory Committee on Immunization Practices for the US Public Health Service and others recommend that all persons 65 years of age and older as well a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213803
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Cognitively stimulating activities contribute to the accumulation of cognitive reserve that is proposed to be instrumental for maintaining cognitive functioning in aging. Adopting a novel, more general conceptual perspective including models of vulnerability, we argue that cognitive reserve may modify the lo...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000501293
更新日期:2020-01-01 00:00:00