Pharmacokinetics of a sustained-release product of indomethacin in the elderly.

abstract：BACKGROUND:Cognitively stimulating activities contribute to the accumulation of cognitive reserve that is proposed to be instrumental for maintaining cognitive functioning in aging. Adopting a novel, more general conceptual perspective including models of vulnerability, we argue that cognitive reserve may modify the lo...

journal_title：Gerontology

authors： Ihle A,Rimmele U,Oris M,Maurer J,Kliegel M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Adults aged 65 years and older stand to benefit from the accumulating wealth of Internet-based health resources, including online interventions to assist in the self-management of chronic health conditions. However, concerns have been expressed that lesser Internet use and familiarity among older adults may ...

journal_title：Gerontology

authors： Crabb RM,Rafie S,Weingardt KR

更新日期：2012-01-01 00:00:00

abstract：:The maximal glucocorticoid responsiveness and the adaptation degree are reduced in old rat liver as demonstrated by cortisol stimulation of RNA polymerases. Nevertheless the concentration of unoccupied 3H-dexamethasone binding sites in molybdate-stabilized cytosol of adrenalectomized old animals is significantly incre...

journal_title：Gerontology

authors： Martin H,Martin R

更新日期：1988-01-01 00:00:00

abstract：:The interactions of ergot alkaloids and of other drugs with dopamine (DA) and alpha-adrenergic receptors were investigated. The tested ergot alkaloids inhibit synaptosomal tyrosine hydroxylase activity and reverse the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Thus, ergot alkaloids ...

journal_title：Gerontology

authors： Goldstein M,Lew JY,Hata F,Lieberman A

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Understanding comorbidity prevalence and the effects of comorbidities in older veterans with lower extremity amputations may aid in assessing patient outcomes, resource use, and facility-level quality of care. OBJECTIVES:To determine the degree to which adding outpatient to inpatient administrative data sou...

journal_title：Gerontology

authors： Kurichi JE,Stineman MG,Kwong PL,Bates BE,Reker DM

更新日期：2007-01-01 00:00:00

abstract：:Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...

journal_title：Gerontology

authors： Peng MT,Hsü HK

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Hypoxia and aging determine on mammalian cells a stress response which implies modified production of oxidants, reactive oxygen species or reactive nitrogen species at the mitochondrial level, interfering with cell-signaling proteins and inducing mitochondrial damage, apoptosis occurrence and functional cons...

journal_title：Gerontology

authors： Zara S,Rapino M,Centurione L,di Giacomo V,Petruccelli G,Cataldi A

更新日期：2010-01-01 00:00:00

abstract：:Sera from 40 elderly individuals ranging in age from 60 to 94 years were tested for the presence of antibodies to varicella-zoster virus (VZV)-specific proteins. Sodium dodecylsulfate polyacrylamide gel electrophoresis analysis of lysates of VZV-infected BSC-1 cells labeled with either [35S]methionine or [3H]mannose a...

journal_title：Gerontology

authors： Vafai A,Mahalingam R,Zerbe G,Wellish M,Gilden DH

更新日期：1988-01-01 00:00:00

abstract：UNLABELLED:BACKGROUND; The link between experiencing difficulties in reading or understanding and non-compliance with drug treatment among seniors is not clearly established. OBJECTIVES:We measured the effect of both difficulties in reading, as well as difficulties in understanding prescription labelling, on non-compl...

journal_title：Gerontology

authors： Moisan J,Gaudet M,Grégoire JP,Bouchard R

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:A quantitative study of dermal and arterial elastic fibers as a function of age was carried out by computerized image analysis. OBJECTIVE:We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal artery in elderly subjects...

journal_title：Gerontology

authors： Gogly B,Godeau G,Septier D,Hornebeck W,Pellat B,Jeandel C

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Malnutrition is a widespread but largely unrecognized problem in aged patients, more so as it is a contributing factor to the increased morbidity and mortality in this age group. Since direct measurements of body composition are not possible in a large number of patients, good anthropometric reference data a...

journal_title：Gerontology

authors： Bonnefoy M,Jauffret M,Kostka T,Jusot JF

更新日期：2002-05-01 00:00:00

abstract：:The concentration of malonaldehyde (MDA) was measured in human erythrocytes obtained from subjects suffering from senile dementia of the Alzheimer type (SDAT), non-demented elderly subjects, and from young controls by two methods: high-performance liquid chromatography (HPLC) and the thiobarbituric acid (TBA) test. Th...

journal_title：Gerontology

authors： Bermejo P,Gómez-Serranillos P,Santos J,Pastor E,Gil P,Martín-Aragón S

更新日期：1997-01-01 00:00:00

abstract：:To determine the influence of age, disease and other factors on anthropometric indices in elderly subjects aged 70 years and above, body mass index (BMI), arm muscle circumference (AMC), corrected arm muscle area (CAMA), fat-free mass (FFM) and total body fat (TBF) were determined in a random sample of 990 Chinese men...

journal_title：Gerontology

authors： Woo J,Ho SC,Sham A,Yuen YK,Chan SG

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To focus on diagnostic and therapeutic problems of pulmonary embolism in the elderly. METHODS:Retrospective analysis of 5 years of clinical, instrumental, and laboratory data (collected at the time of hospital admission) for patients 65 years and older with pulmonary embolism proven by a high-probability sci...

journal_title：Gerontology

authors： Masotti L,Ceccarelli E,Cappelli R,Guerrini M,Forconi S

更新日期：2000-07-01 00:00:00

abstract：:The effects of ageing and of 6 months of Hydergine treatment on lipofuscin deposition within the cytoplasma of pyramidal neurons of rat prefrontal cortex, hippocampus (fields CA1 and CA3) and of Purkinje neurons were assessed microfluorimetrically. No lipofuscin autofluorescence was detected in the nerve cell populati...

journal_title：Gerontology

authors： Amenta D,Ferrante F,Franch F,Amenta F

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Health care providers often believe that individuals with cognitive disturbance are unaware of their deficits. The term unawareness was first used to describe hemiplegia following right hemisphere stroke but has since been applied to unawareness of any neurological or neuropsychological deficit. Clinicians u...

journal_title：Gerontology

authors： McDougall GJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Moderate physical exercise, dietary restriction as well as enriched environment in separate studies have been reported to delay some of the adverse effects of aging on brain function, parallel to an increase in brain-derived neurotrophic factor (BDNF). In order to elucidate these influences in a com...

journal_title：Gerontology

authors： Strasser A,Skalicky M,Hansalik M,Viidik A

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:Due to an increase in the percentage of older people in industrialized countries there is an increasing demand for medical care for the elderly. With advancing age, a series of structural, architectural and compositional modifications take place in the vasculature. Therefore, we analyzed the influence of pat...

journal_title：Gerontology

authors： Kröger K,Strubel G,Poser M,Pratikto T,Renzing-Köhler K,Rudofsky G

更新日期：2004-11-01 00:00:00

abstract：:The effect of aging on plasma erythropoietin (EPO) levels after acute hemorrhage was investigated in ovariectomized (Ovx) rats. Old (22 months), middle (mid)-aged (14 months) and adult (5-6 months) Ovx rats were studied. Rats were anesthetized with ether and bled by heart puncture (5 ml/kg). They were bled again after...

journal_title：Gerontology

authors： Wang RY,Tung YF,Wang PS

更新日期：1995-01-01 00:00:00

abstract：:Various parameters of copulatory behavior were examined in intact and castrated testosterone-(T-)treated male rats of various ages ranging from 3 to 27 months. Serum T levels were controlled by subcutaneous implantation of different sizes of T-filled Silastic capsules at the time of castration. In intact male rats, sc...

journal_title：Gerontology

authors： Hsu HK,Hsu C,Yu JY,Peng MT

更新日期：1986-01-01 00:00:00

abstract：:Patients over 65 years of age admitted to an ophthalmic ward were routinely screened in a standard way practiced in Geriatric Assessment Units. The previous drug therapy of all patients was particularly noted. A classification of the patients with undetected pathology was made and an attempt to categorise the percenta...

journal_title：Gerontology

authors： Andrews J,Pandita-Gunawardena ND,Suntharalingham M

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:The results of the very few histochemical studies that have been performed so far on the lectin-binding profile of normal human epidermis are mostly controversial; thus, the carbohydrate residue composition of the cell surface in the latter still remains in dispute and the possible alterations in the epiderm...

journal_title：Gerontology

authors： Georgiou S,Pasmatzi E,Monastirli A,Sakkis T,Alachioti S,Tsambaos D

更新日期：2005-05-01 00:00:00

abstract：:The biological rhythms of rectal temperature were documented in young (circadian variations) and elderly (circadian and seasonal variations) human subjects either in apparent good health or suffering from senile dementia of Alzheimer type (SDAT). All the subjects were synchronized. Data obtained showed a decrease of t...

journal_title：Gerontology

authors： Touitou Y,Reinberg A,Bogdan A,Auzéby A,Beck H,Touitou C

更新日期：1986-01-01 00:00:00

abstract：:Aging is associated with far-reaching changes in physiological functions resulting in morbidity and ultimately death. Age-related frailty, insecurity and reduced physical activity contribute to a progressive loss of muscle mass and function, commonly referred to as sarcopenia. Due to the increase in life expectancy in...

journal_title：Gerontology

authors： Arnold AS,Egger A,Handschin C

更新日期：2011-01-01 00:00:00

abstract：:The objective of this work was to study patients' self-appraisal of total knee arthroplasty (TKA) 6 and 12 months postoperatively, and to establish which factors determine dissatisfaction from surgery. The study group consisted of 79 patients subjected to TKA who underwent rehabilitation in a specialized institution f...

journal_title：Gerontology

authors： Dickstein R,Heffes Y,Shabtai EI,Markowitz E

更新日期：1998-01-01 00:00:00

abstract：:For logarithmically growing cultures of the human diploid cell lines WI-38 and WI-26, there is an exponential increase in the fraction of cells not incorporating [3H]dT under conditions of continuous labelling. Thymidine uptake, phosphorylation and incorporation into DNA can be correlated with cell proliferation. In a...

journal_title：Gerontology

authors： Cristofalo VJ

更新日期：1976-01-01 00:00:00

abstract：:Some authors have hypothesised that life expectancy at birth could reach 100 years in developed countries in the next decades. Using recent data for French women, it is shown that life expectancy changes from 1993 to 2016 are mainly linked to mortality rates of oldest women. In recent years, it happened that life expe...

journal_title：Gerontology

authors： Le Bourg E

更新日期：2019-01-01 00:00:00

abstract：:The rates of collagen fibril formation are, under otherwise identical conditions, a function of the age of the acid-soluble rat tail tendon collagen utilized. The rate is most rapid with young adult (165 day) collagen, which exhibits no induction period before collagen multimerization begins. In contrast, 21-day colla...

journal_title：Gerontology

authors： Brooks C,Simons ER

更新日期：1978-01-01 00:00:00

abstract：:The specific activities of NAD-linked isocitric dehydrogenase were determined in hypothalamus, cerebellum, pons and medulla, striatum, midbrain, and cerebral cortex (which included the hippocampus) of the female Wistar rat. In ageing the specific activities of this enzyme were decreased in all regions. Chronic treatme...

journal_title：Gerontology

authors： Lai JC,Leung TK,Lim L

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Perceived stress may be a modifiable risk factor for mild cognitive impairment (MCI) and ultimately dementia, but studies on this topic from low- and middle-income countries (LMICs) are lacking. OBJECTIVE:We assessed the association between perceived stress and MCI in six LMICs (China, Ghana, India, Mexico,...

journal_title：Gerontology

authors： Koyanagi A,Oh H,Vancampfort D,Carvalho AF,Veronese N,Stubbs B,Lara E

更新日期：2019-01-01 00:00:00