Abstract:
BACKGROUND:A quantitative study of dermal and arterial elastic fibers as a function of age was carried out by computerized image analysis. OBJECTIVE:We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal artery in elderly subjects. METHODS:we quantitated the skin elastic fibers of the reticular dermis and the elastic fibers of the temporal artery using a specific staining procedure followed by automated image analysis in 16 subjects of age range 63-87 years. RESULTS:There was a good correlation between the area fraction occupied by the elastic fibers in the unexposed skin (inner part of the upper arm) and aging (r = 0.669, p < 0.01). The area fraction occupied by elastic fibers in unexposed skin was correlated with the area fraction occupied by elastic fibers in the deep part of the temporal artery (r = 0.498, p < 0.05). Actinic elastosis affected both tissues, but there was no correlation between the amount of elastotic material in the exposed skin and the area fraction of elastic fibers in the superficial part of the temporal artery. CONCLUSION:We provided evidence that in sun-protected tissues the area fraction occupied by elastic fibers in dermis and deep part of the temporal artery showed a significant correlation. We proposed that skin biopsies were a valuable diagnostic tool for predicting arterial wall abnormalities of elastic fibers.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Gogly B,Godeau G,Septier D,Hornebeck W,Pellat B,Jeandel Cdoi
10.1159/000022035subject
Has Abstractpub_date
1998-01-01 00:00:00pages
318-23issue
6eissn
0304-324Xissn
1423-0003pii
ger44318journal_volume
44pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract::A mathematical model of survivorship kinetics is presented. It takes into account both deterministic and stochastic aspects of survival curves. Earlier reports [Piantanelli: Arch Gerontol Geriatr 1986;5:107-118; Piantanelli: Ann NY Acad Sci 1988; 521:99-109] described a model capable of making distinct predictions on ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213304
更新日期:1992-01-01 00:00:00
abstract::Theophylline kinetics were evaluated in 6 elderly (age 65-75 years) and 5 young (age 22-28 years), nonsmoking males following the oral administration of 200 mg of Elixophylline. Theophylline serum concentration in the postabsorptive phase declined in a monoexponential manner. Total body clearance, elimination half-lif...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212549
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Mortality in the intensive care unit (ICU) rises with age, a high basal serum cortisol and a small response to adrenocorticotropin (ACTH) stimulation. Even slight impairment of the adrenal response during severe illness can be lethal. OBJECTIVES:To determine if age is associated with changes in basal or sti...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000048932
更新日期:2002-03-01 00:00:00
abstract::The eukaryotic stress response involves translational suppression of non-housekeeping proteins and the sequestration of unnecessary mRNA transcripts into stress granules (SGs). This process is dependent on mRNA-binding proteins (RBPs) that interact with capped mRNA transcripts through RNA recognition motifs, and exhib...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000354170
更新日期:2013-01-01 00:00:00
abstract::Phagocytically stimulated canine leukocyte suspensions obtained from 12 young adult and 43 aged individuals were examined for several physiological manifestations of the phagocytically induced respiratory burst. There was considerable variation in levels of oxygen consumption, glucose oxidation via the hexose monophos...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212625
更新日期:1984-01-01 00:00:00
abstract::L-tryptophan (L-T) was added at a dose of 150-450 mg daily to eight Parkinsonian patients who developed visual hallucinations with paranoidal features under L-dopa (L-D) treatment (112.5-75 mg daily) in combination with alpha-methyldopa hydrazine (12.5-75 mg daily). In six patients L-T ameliorated the symptomatology b...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212220
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Although a relationship between diet and mortality is well recognized, there is little information on the extent to which different food sources contribute to survival in elderly people. OBJECTIVE:To examine the effect of individual food groups on mortality in institutionalized elderly people from Asturias ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000135069
更新日期:2008-01-01 00:00:00
abstract::The 'use it or lose it' hypothesis of cognitive aging predicts that engagement in intellectual, social, and physical activities offers protective benefits from age-related cognitive decline and lowers dementia risk. Although this hypothesis has not yet been supported conclusively, there is some empirical evidence in f...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000264918
更新日期:2010-01-01 00:00:00
abstract::Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional altera...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000362548
更新日期:2014-01-01 00:00:00
abstract::The article discusses some aspects demonstrating that a decrease in acetylcholine synthesis in senile dementia of the Alzheimer type (SDAT) is a consequence of the strong decline in glucose turnover in the brain. This becomes obvious by the fact that acetylcoenzyme A, the key substrate of acetylcholine synthesis, is e...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000213592
更新日期:1994-01-01 00:00:00
abstract::In the present study, we examined the changes that occur with age in anti-idiotype-blocked, hapten-augmentable PFC in the mucosal-associated lymph nodes (MLN and BLN) and spleen of various strains of mice. 2-month-old 129/J, AKR/J, and C57L/J mice had a high percentage of hapten-augmentable PFC in their spleen, MLN, a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212708
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:The rate of lipogenesis and gene expression of lipogenic enzymes in white adipose tissue (WAT) of rats decreases with age. Previously, we showed the inverse relationship between serum leptin concentration and lipogenic enzymes activities in WAT of ageing rats. Based on those results, we postulated that lepti...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000187430
更新日期:2009-01-01 00:00:00
abstract::Alloxan diabetes in Swiss mice of both sexes accelerated the ageing of collagen in newly formed cotton pellet granuloma concomitant with its similar effect on dorsal skin. The degree of response of collagen to alloxanization was dependent on the duration of the treatment and the sex of the animal. It is suggested that...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212475
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Although cross-sectional studies have demonstrated associations between visual contrast sensitivity and cognitive test performance, it remains unclear whether peripheral visual or perceptual factors explain the association. OBJECTIVE:We aimed at determining whether reducing static contrast of the study stim...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000090958
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Irrelevant unexpected stimuli elicit various types of inhibitory processes modulated by ongoing activity. An index of the inhibitory processes, namely the N2b and P3a event-related potentials (ERP), shows marked age-related differences. OBJECTIVE:In this experiment, we attempted to separate the effects of i...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000314159
更新日期:2011-01-01 00:00:00
abstract::Dementia is a symptom of a variety of specific structural brain diseases as well as several system degenerations. Alzheimer's disease presently is the commonest cause in the developed world, causing a cortical-subcortical degeneration of ascending cholinergic neurons and large pyramidal cells in the cerebral cortex. C...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212832
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Disturbance of vertical eye movement and ocular convergence is often observed in elderly people, but little is known about its frequency. OBJECTIVE:The purpose of this study was to investigate age-associated changes in vertical eye movement and convergence in healthy elderly people, using a digital video ca...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000076777
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:There is concern that people living in residential care in Australia make significant and often inappropriate use of acute in-patient hospital services. To date, no factual information has been collected in Australia and its absence may allow myths and negative stereotypes to proliferate. OBJECTIVE:To deter...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022148
更新日期:2000-05-01 00:00:00
abstract::Antinuclear antibodies, anticardiolipin antibodies and IgM rheumatoid factor were determined in 300 healthy aged subjects, comparing their prevalence to that in 100 healthy subjects aged between 19 and 44 years and 352 patients under 65 years of age, affected by various systemic rheumatic diseases. Increased productio...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213183
更新日期:1990-01-01 00:00:00
abstract::Older adults have surprisingly high levels of well-being, which has been referred to as a paradox in the past. Improved emotion regulation has been suggested to underlie these high levels of well-being. Later life is also a period with enhanced exposure to critical life events, and this comes with risks. During such t...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000371707
更新日期:2015-01-01 00:00:00
abstract::Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212507
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. OBJECTIVE:To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and fr...
journal_title:Gerontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000494137
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Older adults are stereotypically considered to be risk averse compared to younger age groups, although meta-analyses on age and the influence of gain/loss framing on risky choices have not found empirical evidence for age differences in risk-taking. OBJECTIVE:The current study extends the investigation of a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000487636
更新日期:2018-01-01 00:00:00
abstract::We examined the presenting features, clinical course and prognosis in relation to age in 121 patients with primary biliary cirrhosis (PBC) for a mean follow-up of 4.6 years. 35 patients (29%) were over age 65 years at presentation/detection. There was a higher proportion of patients asymptomatic of liver disease in th...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212701
更新日期:1985-01-01 00:00:00
abstract::Period life expectancy is one of the most used summary indicators for the overall health of a population. Its levels and trends direct health policies, and researchers try to identify the determining risk factors to assess and forecast future developments. The use of period life expectancy is often based on the assump...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000500955
更新日期:2020-01-01 00:00:00
abstract::Recently, Granacher et al. (2010) proposed an intergenerational approach to promoting balance and strength for fall prevention in children and elderly subjects together. Although this sounds like a stimulating idea, its effectiveness for fall prevention in both groups has yet to be demonstrated. Undoubtedly, fall prev...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000322930
更新日期:2011-01-01 00:00:00
abstract::Creatine phosphokinase (CPK) has been shown to provide the initial ATP for muscle contraction. The effect of wheel running on CPK levels was compared in hindleg and cardiac muscles of young, intermediate-age and old outbred CW-1 and inbred C57BL mice. Short-term (5 weeks) and long-term (over 12 months) regimens were u...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212849
更新日期:1987-01-01 00:00:00
abstract::The subcellular distribution of estradiol following the in vivo administration of 3H-estradiol, cytosol and nuclear estrogen receptor after in vitro incubation with 3H-estradiol were studied in young adult female rats (3-6 months old) and old female rats (over 18 months old). After intravenous injection of 3H-estradio...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212449
更新日期:1981-01-01 00:00:00
abstract::Acquisition of immunologic self-tolerance by clonal deletion in the thymus is concluded to be a critical process in immune aging and is found to be transiently protected from genetic instability by means of a feedback surveillance which functions at the expense of chronic thymic involution. In the immune control of ma...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000213604
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Due to aging, tissue regeneration gradually declines. Contemporary strategies to promote tissue-specific regeneration, in particular in elderly patients, often include synthetic material apt for implantation primarily aiming at upholding body functions and regaining appropriate anatomical and functional inte...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000494798
更新日期:2019-01-01 00:00:00