Allergic disorders at a venerable age: a mini-review.

abstract：BACKGROUND:Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. OBJECTIVE:To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and fr...

journal_title：Gerontology

authors： Arrieta H,Hervás G,Rezola-Pardo C,Ruiz-Litago F,Iturburu M,Yanguas JJ,Gil SM,Rodriguez-Larrad A,Irazusta J

更新日期：2019-01-01 00:00:00

abstract：:A trypsin-type protease was purified to enzymatic homogeneity from human umbilical vein endothelial cells by sequential affinity chromatographies. The enzyme specifically hydrolyzed dibasic substrates with leucine at the P3 positions, but scarcely hydrolyzed the other substrates tested. The enzyme was strongly inhibit...

journal_title：Gerontology

authors： Kido H,Takeda M,Wakabayashi H,Tanaka S,Nishimura N,Takenaka M,Okada M

更新日期：1993-01-01 00:00:00

abstract：:Patients over 65 years of age admitted to an ophthalmic ward were routinely screened in a standard way practiced in Geriatric Assessment Units. The previous drug therapy of all patients was particularly noted. A classification of the patients with undetected pathology was made and an attempt to categorise the percenta...

journal_title：Gerontology

authors： Andrews J,Pandita-Gunawardena ND,Suntharalingham M

更新日期：1977-01-01 00:00:00

abstract：:A morphometric analysis of neuronal loss during normal aging was performed in the nucleus basalis Meynert complex of the basal forebrain (Nbm) (nucleus septi medialis, nucleus of Broca's diagonal band, nucleus basalis) and the ciliary ganglion, a peripheral cholinergic structure, in patients free of neurological and p...

journal_title：Gerontology

authors： Bigl V,Arendt T,Fischer S,Fischer S,Werner M,Arendt A

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of cardiopulmonary resuscitation (CPR) and do-not-attempt-resuscitation (DNAR) orders, to define factors associated with CPR/DNAR orders and to explore how physicians make and document these decisions. METHODS:We prospectively reviewed CPR/DNAR forms of 1,446 patients admitted to ...

journal_title：Gerontology

authors： Becerra M,Hurst SA,Junod Perron N,Cochet S,Elger BS

更新日期：2011-01-01 00:00:00

abstract：:100 consecutive endoscopies in elderly patients referred with symptoms after previous gastric surgery are reviewed. 57% showed positive findings, and the procedure was found particularly useful in making definitive diagnoses in patients presenting with dyspepsia and upper gastro-intestinal bleeding. The incidence of g...

journal_title：Gerontology

authors： Gibbins FJ,Gupta SD,Sen I

更新日期：1985-01-01 00:00:00

abstract：UNLABELLED:BACKGROUND; The link between experiencing difficulties in reading or understanding and non-compliance with drug treatment among seniors is not clearly established. OBJECTIVES:We measured the effect of both difficulties in reading, as well as difficulties in understanding prescription labelling, on non-compl...

journal_title：Gerontology

authors： Moisan J,Gaudet M,Grégoire JP,Bouchard R

更新日期：2002-01-01 00:00:00

abstract：:In the present study, we examined the changes that occur with age in anti-idiotype-blocked, hapten-augmentable PFC in the mucosal-associated lymph nodes (MLN and BLN) and spleen of various strains of mice. 2-month-old 129/J, AKR/J, and C57L/J mice had a high percentage of hapten-augmentable PFC in their spleen, MLN, a...

journal_title：Gerontology

authors： Szewczuk MR,Wade AW

更新日期：1985-01-01 00:00:00

abstract：:The heat shock protein (HSP) system is a mechanism of cell defense induced by stress, constitutively expressed during basal conditions and essential to the maintenance of cellular integrity. Acutely induced HSP synthesis decreases with aging, but the effect of age on the basal expression of HSP70 has not been specific...

journal_title：Gerontology

authors： Maiello M,Boeri D,Sampietro L,Pronzato MA,Odetti P,Marinari UM

更新日期：1998-01-01 00:00:00

abstract：:We examined age- and diet-related alterations in RNA poly(A) tail length using high-resolution gel electrophoresis followed by Northern hybridization. The results demonstrate conclusively that there is no age-related decrease in the size of the Poly(A) tail of RNA isolated from the male Fischer 344 rat. In contrast, o...

journal_title：Gerontology

authors： Kristal BS,Conrad CC,Richarson A,Yu BP

更新日期：1993-01-01 00:00:00

abstract：:Acquisition of immunologic self-tolerance by clonal deletion in the thymus is concluded to be a critical process in immune aging and is found to be transiently protected from genetic instability by means of a feedback surveillance which functions at the expense of chronic thymic involution. In the immune control of ma...

journal_title：Gerontology

authors： Hartwig M

更新日期：1994-01-01 00:00:00

abstract：:In the absence of a single marker that reliably reflects biological aging, or even an exact definition of biological age, compound aging scores that combine multiple aging biomarkers into a single composite aging score can quantitatively reflect the age-related changes over time. If aging is viewed as the broad accumu...

journal_title：Gerontology

authors： Shamir L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Werner's syndrome, a rare autosomal recessive disorder, is characterized by features of premature aging. Seventy-five percent of the alleles of Japanese patients with Werner's syndrome have one of three major mutations. OBJECTIVE:To determine the genotype of a patient with Werner's syndrome. METHODS:We dia...

journal_title：Gerontology

authors： Nakayama T,Ochiai T,Takahashi Y,Ohkubo K,Hironaga T,Kokubun S

更新日期：2002-07-01 00:00:00

abstract：:We quantitated the skin elastic fibers of the papillary and reticular dermis using specific staining procedure followed by automated computerized image analysis. Fifty skin biopsies of patients consulting for cardiovascular risk factors were studied. The following parameters were estimated: surface area (% of total su...

journal_title：Gerontology

authors： Robert C,Lesty C,Robert AM

更新日期：1988-01-01 00:00:00

abstract：:Various parameters of copulatory behavior were examined in intact and castrated testosterone-(T-)treated male rats of various ages ranging from 3 to 27 months. Serum T levels were controlled by subcutaneous implantation of different sizes of T-filled Silastic capsules at the time of castration. In intact male rats, sc...

journal_title：Gerontology

authors： Hsu HK,Hsu C,Yu JY,Peng MT

更新日期：1986-01-01 00:00:00

abstract：:Empirical evidence for the conjecture that brain weight of mammals is a better predictor of life span than is body weight, is reexamined and evaluated in this paper. The original evidence was that for 63 mammalian species, log brain weight explained 79% of the log life span variance, whereas log body weight explained ...

journal_title：Gerontology

authors： Economos AC

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that vitamin D status may be relevant for physical and cognitive performance in the older population. This association may be of particular interest to older people at risk for cognitive impairment and functional decline. OBJECTIVE:The aim of this study was to determine the associa...

journal_title：Gerontology

authors： Gschwind YJ,Bischoff-Ferrari HA,Bridenbaugh SA,Härdi I,Kressig RW

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The perioperative assessment and management of elderly patients with hip fracture and significant aortic stenosis (AS) is an increasingly common clinical problem with little data available to guide perioperative management. OBJECTIVES:It was the aim of this study to examine the incidence of perioperative ev...

journal_title：Gerontology

authors： Leibowitz D,Rivkin G,Schiffman J,Rott D,Weiss AT,Mattan Y,Kandel L

更新日期：2009-01-01 00:00:00

abstract：:A profound influence of steroidal (and possibly growth) hormone change during aging on the P-450 functions has been found in male rats. Direct and rapid autonomic nervous controls on glycogen metabolism in the liver is also greatly affected by aging. However, neither the responses of isolated rat hepatocyte preparatio...

journal_title：Gerontology

authors： Kitani K

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Hypoxia and aging determine on mammalian cells a stress response which implies modified production of oxidants, reactive oxygen species or reactive nitrogen species at the mitochondrial level, interfering with cell-signaling proteins and inducing mitochondrial damage, apoptosis occurrence and functional cons...

journal_title：Gerontology

authors： Zara S,Rapino M,Centurione L,di Giacomo V,Petruccelli G,Cataldi A

更新日期：2010-01-01 00:00:00

abstract：:The glucose uptake of lizard brain slices decreased between young and middle-aged groups. There was a significant increase in the parameter between the middle-aged and old-age groups. Cold shock induced a decrease in glucose uptake of brain slices in the old, with no appreciable effect in the young and middle aged. ...

journal_title：Gerontology

authors： Dash BD,Patnaik BK

更新日期：1989-01-01 00:00:00

abstract：:Mechanisms underlying the decreased febrile response in the elderly have not been elucidated. One hypothesis is that elderly persons have a decreased response at the hypothalamic or peripheral effector level to endogenous pyrogen (EP). We studied the response to human monocyte-derived EP in young adult and aged Fische...

journal_title：Gerontology

authors： Tocco-Bradley R,Singer R,Kluger MJ,Kauffman CA

更新日期：1985-01-01 00:00:00

abstract：:The maximal glucocorticoid responsiveness and the adaptation degree are reduced in old rat liver as demonstrated by cortisol stimulation of RNA polymerases. Nevertheless the concentration of unoccupied 3H-dexamethasone binding sites in molybdate-stabilized cytosol of adrenalectomized old animals is significantly incre...

journal_title：Gerontology

authors： Martin H,Martin R

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:There is concern that people living in residential care in Australia make significant and often inappropriate use of acute in-patient hospital services. To date, no factual information has been collected in Australia and its absence may allow myths and negative stereotypes to proliferate. OBJECTIVE:To deter...

journal_title：Gerontology

authors： Finucane P,Wundke R,Whitehead C,Williamson L,Baggoley C

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Falls are a significant problem for older adults. Individuals who have sustained a fall come to the attention of health care providers and are at risk of further falls. To promote the highest quality of care and reduce variation in care, a practice guideline is needed. Summarization of evidence regarding fal...

journal_title：Gerontology

authors： Moreland J,Richardson J,Chan D,O'Neill J,Bellissimo A,Grum R,Shanks L

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:A large proportion of falls in older people are caused by slipping. Previous occupational safety research suggests that inadequate footwear may contribute to slipping accidents; however, no studies have assessed the slip resistance of casual footwear. OBJECTIVE:To evaluate the slip resistance of different t...

journal_title：Gerontology

authors： Menz HB,Lord ST,McIntosh AS

更新日期：2001-05-01 00:00:00

abstract：:A group of clinical senile dementia patients underwent a series of cerebrovascular examinations. Some of them were standard examinations (fundus oculi, electroencephalogram, rheoencephalogram, cerebral angiogram and pneumonencephalogram) while the others were studying regional cerebral blood flow (rCBF) and modificati...

journal_title：Gerontology

authors： Dekoninck WJ,Collard M,Noel G

更新日期：1977-01-01 00:00:00

abstract：:We studied the correlation between the in vitro lymphocyte proliferative response and some early parameters of lymphocyte activation in aged people. While a consistent number of elderly subjects showed significantly decreased proliferative responses to mitogen stimulation, interleukin-1 (IL-1) production and IL-2 rece...

journal_title：Gerontology

authors： Amadori A,Zanovello P,Cozzi E,Ciminale V,Borghesan F,Fagiolo U,Crepaldi G

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:During development and aging, as well as under hypoxia, many cells can adapt to a stressful environment, while others are damaged and die by apoptosis. In particular, intermittent hypoxia, i.e., hypoxia followed by reoxygenation, determines different responses in young and adult myocardia. OBJECTIVE:In the ...

journal_title：Gerontology

authors： Bianchi G,Di Giulio C,Rapino C,Rapino M,Antonucci A,Cataldi A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Cardiac surgery is widely believed to be an excessively high-risk intervention for very elderly patients with coronary artery or valvular disease. However, as life expectancy and the prospect of sustained quality of life into older age increase, this assumption should be challenged so that surgery is not den...

journal_title：Gerontology

authors： Guilfoyle MR,Drain AJ,Khan A,Ferguson J,Large SR,Nashef SA

更新日期：2010-01-01 00:00:00