Abstract:
:Acquisition of immunologic self-tolerance by clonal deletion in the thymus is concluded to be a critical process in immune aging and is found to be transiently protected from genetic instability by means of a feedback surveillance which functions at the expense of chronic thymic involution. In the immune control of mammalian aging, principles of Darwinian natural selection are suggested to work at the cellular level. During life, an immune-mediated stabilizing cell selection is displaced by a destabilizing one, thus changing physiological to pathological aging. In consequence, mammalian aging may be approached from an evolutionary point of view by both genetic cell variation and immune selection and be revealed correspondingly both as a stochastic and programmed process. Age-dependent diseases may be characterized as the consequence of localized pathological aging.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Hartwig Mdoi
10.1159/000213604subject
Has Abstractpub_date
1994-01-01 00:00:00pages
307-13issue
6eissn
0304-324Xissn
1423-0003journal_volume
40pub_type
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