(Na+-K+)-ATPase activity and ouabain-binding sites in the cerebral cortex of young and aged Fischer-344 rats.

Abstract:

:(Na+-K+)-ATPase is an enzyme responsible for ionic homeostasis in excitable tissues. Thus, the activity of this enzyme is essential for the maintenance of optimal function of the cerebral cortex. Although abnormalities of cerebral oxidative metabolism have been described in aging, these abnormalities do not appear to be associated with changes in the in vitro enzyme characteristics of (Na+-K+)-ATPase. Specifically, there were no significant differences between preparations from the cerebral cortex of 3- and 28-month-old Fischer-344 rats in their: (i) high-affinity binding to [3H]-ouabain, (ii) number of ouabain-binding sites, or (iii) K+-p-nitrophenylphosphatase activity.

journal_name

Gerontology

journal_title

Gerontology

authors

LaManna JC,Doull G,McCracken K,Harik SI

doi

10.1159/000213123

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

242-7

issue

4

eissn

0304-324X

issn

1423-0003

journal_volume

29

pub_type

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