Abstract:
BACKGROUND:The prevalence of aortic stenosis is nearly 20% in octogenarians. Aortic valve replacement (AVR) is the optimal therapy choice, yet many symptomatic patients are denied this beneficent technology. Whether mechanical or bioprosthetic, aortic valves are not a scarce resource and their safety, effectiveness and longevity are proven. OBJECTIVE:Because the geriatric population is soaring, clinicians will be encountering more cases of aortic stenosis and the decision-making that leads to surgical referral or non-referral warrants exploration. METHODS:A literature review was conducted to explore the notion that physicians deny AVR to their patients based solely on their chronological age value. RESULTS:Using age as the sole exclusion criterion, medical literature documents the fact that AVR is frequently denied to the elderly. CONCLUSION:It appears that AVR is another beneficent cardiac technology that has been added to the age discrimination list, even though the devices are not scarce, they are cost-effective, and they can improve the life of a symptomatic elderly patient. There is no ethical justification for denying AVR to clinically suitable elderly candidates who request such therapy.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Bramstedt KAdoi
10.1159/000066502keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
46-9issue
1eissn
0304-324Xissn
1423-0003pii
66502journal_volume
49pub_type
杂志文章,评审相关文献
GERONTOLOGY文献大全abstract:BACKGROUND:The oral cavity is a reservoir for colonization and infection of systemic organs by pathogenic bacteria. It is understood that aging, tooth eruption, hormonal changes, active disease, oral hygiene, and other factors have an influence on biofilm formation and bacterial accumulation in the oral cavity. OBJECT...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000071711
更新日期:2003-09-01 00:00:00
abstract::A mathematical model of survivorship kinetics is presented. It takes into account both deterministic and stochastic aspects of survival curves. Earlier reports [Piantanelli: Arch Gerontol Geriatr 1986;5:107-118; Piantanelli: Ann NY Acad Sci 1988; 521:99-109] described a model capable of making distinct predictions on ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213304
更新日期:1992-01-01 00:00:00
abstract::The effect of ageing on the threshold firing rate of motor units from the first dorsal interosseous muscle was investigated. Two groups of 9 healthy male subjects between the ages of 20-29 and 60-69 years took part in the study. The threshold firing rate of motor units in young subjects showed close agreement with pre...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212939
更新日期:1988-01-01 00:00:00
abstract::This review focuses on 3 allergic disorders of persons coming up against venerable age: asthma, allergic rhinitis, and atopic dermatitis. The prevalence of allergic diseases in the elderly ranges from 5 to 10% and appears to be rising. A gradual decline in immune function, termed immunosenescence, and age-related chan...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000355307
更新日期:2014-01-01 00:00:00
abstract::Both ageing and vitamin C (VC) deficiency result in immune defect. Since low serum and tissue levels of VC are found in the elderly, we have in a placebo-controlled study, tested the effect of VC supplements (500 mg/day i.m. for 1 month) on various immune parameters. Indeed, VC enhances the proliferative response of T...
journal_title:Gerontology
pub_type: 临床试验,杂志文章
doi:10.1159/000213131
更新日期:1983-01-01 00:00:00
abstract::The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212326
更新日期:1979-01-01 00:00:00
abstract::Typically, subjective memory assessments (be it in form of single items or questionnaires) in old age only weakly correlate with the performance in objective memory tests at cross-section. It thus appears as if individual differences in subjective memory assessments hardly reflect individual differences in memory in o...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000369927
更新日期:2015-01-01 00:00:00
abstract::A group of clinical senile dementia patients underwent a series of cerebrovascular examinations. Some of them were standard examinations (fundus oculi, electroencephalogram, rheoencephalogram, cerebral angiogram and pneumonencephalogram) while the others were studying regional cerebral blood flow (rCBF) and modificati...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212183
更新日期:1977-01-01 00:00:00
abstract::Sera from 40 elderly individuals ranging in age from 60 to 94 years were tested for the presence of antibodies to varicella-zoster virus (VZV)-specific proteins. Sodium dodecylsulfate polyacrylamide gel electrophoresis analysis of lysates of VZV-infected BSC-1 cells labeled with either [35S]methionine or [3H]mannose a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212962
更新日期:1988-01-01 00:00:00
abstract::Morphometric measurements have been carried out on the human myenteric esophageal neurons at the ages of 20-40 and more than 70 years. The number of neurons decreases after 70 years of age, which is accompanied by an increase in the sizes of the neurons. In percentage terms the decrease in the number of neurons in the...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213658
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Understanding comorbidity prevalence and the effects of comorbidities in older veterans with lower extremity amputations may aid in assessing patient outcomes, resource use, and facility-level quality of care. OBJECTIVES:To determine the degree to which adding outpatient to inpatient administrative data sou...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000101703
更新日期:2007-01-01 00:00:00
abstract::Older adults often face challenges as they transition out of the acute care hospital, especially with regard to adhering to their medications. In this narrative review, we discuss medication adherence in older adults across the continuum of care, describing reasons for nonadherence, methods to assess adherence and too...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000363765
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Proxy decision-making may be flawed by inaccurate perceptions of risk. This may be particularly true when older adults are the targets of the decisions, given the pervasive negative stereotypes about older adults. METHODS:In study 1, individuals aged 18- to 87 years (as target persons) as wel...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000494352
更新日期:2019-01-01 00:00:00
abstract::Various parameters of copulatory behavior were examined in intact and castrated testosterone-(T-)treated male rats of various ages ranging from 3 to 27 months. Serum T levels were controlled by subcutaneous implantation of different sizes of T-filled Silastic capsules at the time of castration. In intact male rats, sc...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212760
更新日期:1986-01-01 00:00:00
abstract::The subcellular distribution of estradiol following the in vivo administration of 3H-estradiol, cytosol and nuclear estrogen receptor after in vitro incubation with 3H-estradiol were studied in young adult female rats (3-6 months old) and old female rats (over 18 months old). After intravenous injection of 3H-estradio...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212449
更新日期:1981-01-01 00:00:00
abstract::In three mouse lineages it was found that during the 18- to 60-day interval after formalin fixation, brain weight was inversely proportional to the age at sacrifice, as was the decline in the weight of the brain during this period. In a second study using rat subjects it was confirmed that the aging difference is due ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212460
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:The common cause account suggests that there is a third factor causing aging effects in both sensory and cognitive functioning, hypothesized to be the integrity of the central nervous system [Lindenberger and Baltes; Psychol Aging 1994;9:339-355]. Importantly, the common cause account was developed based on ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000279754
更新日期:2010-01-01 00:00:00
abstract::Theophylline kinetics were evaluated in 6 elderly (age 65-75 years) and 5 young (age 22-28 years), nonsmoking males following the oral administration of 200 mg of Elixophylline. Theophylline serum concentration in the postabsorptive phase declined in a monoexponential manner. Total body clearance, elimination half-lif...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212549
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Mild-to-moderate chronic kidney disease (CKD G3a) is prevalent in older adults. Substantial evidence suggests that individuals with advanced CKD face a high risk for common geriatric conditions, like functional impairment and cognitive decline, whereas the relationships between mild-to-moderate CKD and funct...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000484140
更新日期:2018-01-01 00:00:00
abstract::The usual features of Paget's disease of bone, e.g. large head, deafness due to involvement of the 8th cranial nerve and bowing of the legs are all well described in text books of medicine. However, some features such as platybasia with neurological deficit, involvement of the 2nd, 5th and 7th cranial nerves, hydrocep...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212286
更新日期:1978-01-01 00:00:00
abstract::Neurofilament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer's disease. The abnormally proliferated neurofilament was characterized by immunostaining and electron microscopy. The intracytoplasmic neurofilament ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213295
更新日期:1991-01-01 00:00:00
abstract::During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213514
更新日期:1993-01-01 00:00:00
abstract::The activity of ceruloplasmin (CP) increased 3-fold in rat blood between 1 week and 20 months of age, but the difference in CP activity of adult and old rats was only 14%, which still is statistically significant (p less than 0.01). The increase in NaCl and KCl concentrations in vitro resulted in the same exponential ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213261
更新日期:1991-01-01 00:00:00
abstract::The Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or ...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000453579
更新日期:2017-01-01 00:00:00
abstract::The specific activities of NAD-linked isocitric dehydrogenase were determined in hypothalamus, cerebellum, pons and medulla, striatum, midbrain, and cerebral cortex (which included the hippocampus) of the female Wistar rat. In ageing the specific activities of this enzyme were decreased in all regions. Chronic treatme...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212514
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Despite declines in cognitive abilities, older adults often perform comparable to younger adults in everyday tasks [J Am Geriatr Soc 1999;47:172-183]. Older adults may compensate for cognitive declines by using more efficient strategies. People often improve their efficiency by switching from an algorithmic ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000446277
更新日期:2016-01-01 00:00:00
abstract::The heat shock protein (HSP) system is a mechanism of cell defense induced by stress, constitutively expressed during basal conditions and essential to the maintenance of cellular integrity. Acutely induced HSP synthesis decreases with aging, but the effect of age on the basal expression of HSP70 has not been specific...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000021977
更新日期:1998-01-01 00:00:00
abstract::Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because ...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000353857
更新日期:2013-01-01 00:00:00
abstract::The relation between carotid blood flow measured by Doppler spectrum analysis and brain atrophy on computed tomography (CT) was studied in 22 subjects with multiple lacunar cerebral infarctions. The subjects were divided into two groups, 7 patients with multi-infarct dementia (MID) (mean age 73 years) and 15 nondement...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213022
更新日期:1989-01-01 00:00:00
abstract::Glutamine synthetase (GS) activity was measured in whole brain, different brain areas, liver and heart of 23- to 26-month-old rats, and then compared to matched animals of 3 months. A significant increase of GS activity was found in whole brain (25%) of old rats, as well as in all brain areas studied, but particularly...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212686
更新日期:1985-01-01 00:00:00