Zika Virus Infection in the Elderly: Possible Relationship with Guillain-Barré Syndrome.

Abstract:

:The Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or gastrointestinal infectious diseases. Despite being relatively rare, the incidence rate of GBS rises with age, which makes GBS more frequent in the elderly, in whom it is also a more severe disease with slower recovery than in younger patients. Different forms of GBS have been described having diagnostic confirmation of a previous infection with the ZIKV virus. Although we do not have enough evidence that elderly people are a particularly susceptible population to developing GBS following ZIKV infection, this is plausible. We should consider this possibility, particularly taking into account that aging subjects are more susceptible to infections. In this context, a deeper understanding of how the immune system in the elderly functions in relation to ZIKV infection is necessary, as well as an understanding of what kind of alterations of the nervous system such an infection triggers in the elderly, beyond GBS. This will be relevant for better therapeutic interventions and for designing vaccine candidates that can be applied in an aging population, particularly those prone to develop ZIKV-induced autoimmunity.

journal_name

Gerontology

journal_title

Gerontology

authors

Savino W,Messias CV,Mendes-da-Cruz DA,Passos P,Ferreira AC,Nascimento OJ

doi

10.1159/000453579

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

210-215

issue

3

eissn

0304-324X

issn

1423-0003

pii

000453579

journal_volume

63

pub_type

杂志文章,评审
  • Electrolytes and free amino acids in leg skeletal muscle of young and elderly women.

    abstract::Electrolytes and/or amino acids were determined in leg skeletal muscle biopsies from elderly (age range 57-75 years) and young (age range 20-35 years) apparently healthy women. When compared to the young group, the elderly one was characterized by increased levels of muscular Na+ and Cl-, while the calculated intracel...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213088

    authors: Möller P,Alvestrand A,Bergström J,Fürst P,Hellström K

    更新日期:1983-01-01 00:00:00

  • Perception of Risk for Older Adults: Differences in Evaluations for Self versus Others and across Risk Domains.

    abstract:BACKGROUND AND OBJECTIVES:Proxy decision-making may be flawed by inaccurate perceptions of risk. This may be particularly true when older adults are the targets of the decisions, given the pervasive negative stereotypes about older adults. METHODS:In study 1, individuals aged 18- to 87 years (as target persons) as wel...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000494352

    authors: Rolison JJ,Hanoch Y,Freund AM

    更新日期:2019-01-01 00:00:00

  • Future time perspective: opportunities and limitations are differentially associated with subjective well-being and hair cortisol concentration.

    abstract:BACKGROUND:Future time perspective has been associated with subjective well-being, though depending on the line of research considered either an open-ended future time perspective or a limited future time perspective has been associated with high well-being. Most of this research however has conceptualized future time ...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000368716

    authors: Kozik P,Hoppmann CA,Gerstorf D

    更新日期:2015-01-01 00:00:00

  • Age-related difference in the response of plasma erythropoietin to hemorrhage in ovariectomized rats.

    abstract::The effect of aging on plasma erythropoietin (EPO) levels after acute hemorrhage was investigated in ovariectomized (Ovx) rats. Old (22 months), middle (mid)-aged (14 months) and adult (5-6 months) Ovx rats were studied. Rats were anesthetized with ether and bled by heart puncture (5 ml/kg). They were bled again after...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213666

    authors: Wang RY,Tung YF,Wang PS

    更新日期:1995-01-01 00:00:00

  • Lipid peroxidation and ceroid accumulation in macrophages cultured with oxidized low density lipoprotein.

    abstract::When mouse peritoneal macrophages were cultured with oxidized human low density lipoprotein (ox-LDL), storage of ceroid-like pigments was observed within the cells by light and fluorescent microscopy, and fluorescence spectrophotometry. The fluorescent products exhibit the characteristics of Schiff base structures, ha...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213724

    authors: Shimasaki H,Maeba R,Tachibana R,Ueta N

    更新日期:1995-01-01 00:00:00

  • Modelling survivorship kinetics: a two-parameter model.

    abstract::A mathematical model of survivorship kinetics is presented. It takes into account both deterministic and stochastic aspects of survival curves. Earlier reports [Piantanelli: Arch Gerontol Geriatr 1986;5:107-118; Piantanelli: Ann NY Acad Sci 1988; 521:99-109] described a model capable of making distinct predictions on ...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213304

    authors: Piantanelli L,Rossolini G,Nisbet R

    更新日期:1992-01-01 00:00:00

  • Effectiveness of influenza vaccine in the elderly.

    abstract:OBJECTIVE:Each year, influenza and its complications account for 10,000-40,000 excess deaths in the United States. Over 80% of these deaths occur among the elderly. The Advisory Committee on Immunization Practices for the US Public Health Service and others recommend that all persons 65 years of age and older as well a...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213803

    authors: Nichol KL,Margolis KL,Wouremna J,von Sternberg T

    更新日期:1996-01-01 00:00:00

  • Recovery of functional impairment after acute illness and mortality: one-year follow-up study.

    abstract:BACKGROUND:Functional status in older people is a dynamic situation, which makes it necessary to evaluate functional capacity at different times to determinate their prognostic value. OBJECTIVE:To examine the association between functional status (baseline and change after acute illness) and mortality and functional c...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000193068

    authors: Baztán JJ,Gálvez CP,Socorro A

    更新日期:2009-01-01 00:00:00

  • Aging and Decision-Making: A Conceptual Framework for Future Research - A Mini-Review.

    abstract::Age differences in decision-making are of theoretical interest and have important practical implications, but relevant lines of work are distributed across multiple disciplines and often lack integration. The present review proposes an overarching conceptual framework with the aim of connecting disjointed aspects of t...

    journal_title:Gerontology

    pub_type: 杂志文章,评审

    doi:10.1159/000485247

    authors: Löckenhoff CE

    更新日期:2018-01-01 00:00:00

  • Predictors of improvement or decline in instrumental activities of daily living among community-dwelling older Japanese.

    abstract:BACKGROUND:To explore predictors of functional improvement or decline in instrumental activities of daily living (IADL) among community-dwelling older people. METHODS:Of all the residents (>or=65 years, n = 1,673) living in Yoita town, Niigata prefecture, Japan, in 2000, 1,544 subjects who participated in the baseline...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000151221

    authors: Fujiwara Y,Yoshida H,Amano H,Fukaya T,Liang J,Uchida H,Shinkai S

    更新日期:2008-01-01 00:00:00

  • Some unusual features of Paget's disease of bone.

    abstract::The usual features of Paget's disease of bone, e.g. large head, deafness due to involvement of the 8th cranial nerve and bowing of the legs are all well described in text books of medicine. However, some features such as platybasia with neurological deficit, involvement of the 2nd, 5th and 7th cranial nerves, hydrocep...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212286

    authors: Chakravorty NK

    更新日期:1978-01-01 00:00:00

  • Role of stress granules and RNA-binding proteins in neurodegeneration: a mini-review.

    abstract::The eukaryotic stress response involves translational suppression of non-housekeeping proteins and the sequestration of unnecessary mRNA transcripts into stress granules (SGs). This process is dependent on mRNA-binding proteins (RBPs) that interact with capped mRNA transcripts through RNA recognition motifs, and exhib...

    journal_title:Gerontology

    pub_type: 杂志文章,评审

    doi:10.1159/000354170

    authors: Vanderweyde T,Youmans K,Liu-Yesucevitz L,Wolozin B

    更新日期:2013-01-01 00:00:00

  • Standing Up Slowly Antagonises Initial Blood Pressure Decrease in Older Adults with Orthostatic Hypotension.

    abstract:BACKGROUND:Orthostatic hypotension (OH) is common in older adults and associated with increased morbidity and mortality, loss of independence and high health-care costs. Standing up slowly is a recommended non-pharmacological intervention. However, the effectiveness of this advice has not been well studied. OBJECTIVES...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000450642

    authors: de Bruïne ES,Reijnierse EM,Trappenburg MC,Pasma JH,de Vries OJ,Meskers CG,Maier AB

    更新日期:2017-01-01 00:00:00

  • Age, Loss Minimization, and the Role of Probability for Decision-Making.

    abstract:BACKGROUND:Older adults are stereotypically considered to be risk averse compared to younger age groups, although meta-analyses on age and the influence of gain/loss framing on risky choices have not found empirical evidence for age differences in risk-taking. OBJECTIVE:The current study extends the investigation of a...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000487636

    authors: Best R,Freund AM

    更新日期:2018-01-01 00:00:00

  • Is renal biopsy justified for the diagnosis and management of the nephrotic syndrome in the elderly?

    abstract::During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213514

    authors: Moran D,Korzets Z,Bernheim J,Bernheim J,Yaretzky A

    更新日期:1993-01-01 00:00:00

  • Deficiency of the growth hormone-insulin-like growth factor-I axis potentially involved in age-related alterations in body composition.

    abstract::Because the body composition effects of growth hormone and insulin-like growth factor-I (IGF-I) are opposite to those of advancing age, it has been hypothesized that the decreased activity of the growth hormone-IGF-I axis is partly responsible for the loss of bone and muscle mass that characterizes normal human aging....

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213811

    authors: Boonen S,Lesaffre E,Aerssens J,Pelemans W,Dequeker J,Bouillon R

    更新日期:1996-01-01 00:00:00

  • An intergenerational approach in promoting balance and strength for fall prevention: evidence-based or evidence-inspired?

    abstract::Recently, Granacher et al. (2010) proposed an intergenerational approach to promoting balance and strength for fall prevention in children and elderly subjects together. Although this sounds like a stimulating idea, its effectiveness for fall prevention in both groups has yet to be demonstrated. Undoubtedly, fall prev...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000322930

    authors: Burtscher M,Kopp M

    更新日期:2011-01-01 00:00:00

  • Neurohumoral control of liver functions during aging.

    abstract::A profound influence of steroidal (and possibly growth) hormone change during aging on the P-450 functions has been found in male rats. Direct and rapid autonomic nervous controls on glycogen metabolism in the liver is also greatly affected by aging. However, neither the responses of isolated rat hepatocyte preparatio...

    journal_title:Gerontology

    pub_type: 杂志文章,评审

    doi:10.1159/000212931

    authors: Kitani K

    更新日期:1988-01-01 00:00:00

  • The long-stay patient.

    abstract::The characteristics of long-stay patients (defined as those staying more than 6 months) have been studied in a prospective series of 2,405 admissions. 5.6% become long-stay patients and they were more likely to be women, to be readmissions, to have been admitted from an old people's home, to have been non-emergency ad...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212467

    authors: Hodkinson I,Hodkinson HM

    更新日期:1981-01-01 00:00:00

  • Influence of dietary copper on the survival of Drosophila.

    abstract::The life span of Drosophila melanogaster was reduced when copper compounds were fed at concentrations of 1 X 10(-3) M or greater. Feeding lower concentrations of copper compounds failed to significantly change life span. A combination of copper gluconate and gluconic acid increased the adult life span by 21.6%. We con...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212611

    authors: Massie HR,Williams TR,Aiello VR

    更新日期:1984-01-01 00:00:00

  • Complex Gait Is Related to Cognitive Functioning in Older People: A Cross-Sectional Study Providing an Innovative Test.

    abstract:BACKGROUND:Many studies have demonstrated an inverse relationship between gait performance and cognitive impairment. The main purposes of this study were: (1) to design and validate a complex gait test (CGT) in older people, (2) to analyze the effects of age and sex on CGT, and (3) to analyze the association between CG...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000508245

    authors: Latorre Román PÁ,Muñoz Jiménez M,Salas Sánchez J,Consuegra González P,Moreno Del Castillo R,Herrador Sánchez JA,López Ivanco MDA,Linares Jiménez C,Navas Morales JF,Párraga Montilla JA

    更新日期:2020-01-01 00:00:00

  • Altered plasma nerve growth factor-like immunoreactivity and nerve growth factor-receptor expression in human old age.

    abstract:BACKGROUND:Nerve growth factor (NGF), discovered because of its action on cells in the peripheral and the central nervous system, is now known to act also on immune cells in developing and adult subjects. Whether peripheral lymphocytes of aged subjects are responsive to this molecule is less clear. OBJECTIVE:Aim of ou...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000069170

    authors: Antonelli A,Bracci-Laudiero L,Aloe L

    更新日期:2003-05-01 00:00:00

  • Prevalence and facility level correlates of need for wheelchair seating assessment among long-term care residents.

    abstract:BACKGROUND:Wheelchairs are frequently prescribed for residents with mobility impairments in long-term care. Many residents receive poorly fitting wheelchairs, compromising functional independence and mobility, and contributing to subsequent health issues such as pressure ulcers. The extent of this problem and the facto...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000334819

    authors: Giesbrecht EM,Mortenson WB,Miller WC

    更新日期:2012-01-01 00:00:00

  • Can atherosclerosis regress? The role of the vascular extracellular matrix and the age-related changes of arteries.

    abstract:BACKGROUND:Previous extensive clinical studies, using angiography or ultrasound, investigated the influence of alimentary, medicamentous and other antiatherosclerotic measures on the degree of atherosclerosis. The following signs of regression were found: clinical improvement, changes in tonus of vascular walls, format...

    journal_title:Gerontology

    pub_type: 杂志文章,评审

    doi:10.1159/000065248

    authors: Kunz J

    更新日期:2002-09-01 00:00:00

  • Relationship among activities of daily living, apathy, and subjective well-being in elderly people living alone in a rural town.

    abstract:BACKGROUND:There are limited psychological data on the quality of life and activities of daily living among elderly Japanese who live alone. OBJECTIVE:The aim of this study was to examine the frequency of apathy and its correlation with activities of daily living and with subjective well-being in elderly people living...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000022102

    authors: Yamashita K,Iijima K,Kobayashi S

    更新日期:1999-09-01 00:00:00

  • Is poly(A) tail length altered by aging or dietary restriction?

    abstract::We examined age- and diet-related alterations in RNA poly(A) tail length using high-resolution gel electrophoresis followed by Northern hybridization. The results demonstrate conclusively that there is no age-related decrease in the size of the Poly(A) tail of RNA isolated from the male Fischer 344 rat. In contrast, o...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213527

    authors: Kristal BS,Conrad CC,Richarson A,Yu BP

    更新日期:1993-01-01 00:00:00

  • Immune reactivity and attractiveness.

    abstract::Over the past decades, information about the characteristics of attractiveness has accumulated. We know about eight pillars of beauty, among them youthfulness, symmetry, hormone markers and body odor. But what is the biological function of these attractive signals? Is there one common function to be found in all eight...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000265559

    authors: Oberzaucher E,Grammer K

    更新日期:2010-01-01 00:00:00

  • Expression of High Mobility Group Protein B1 in Cardiac Tissue of Elderly Patients with Coronary Artery Disease with or without Inflammatory Rheumatic Disease.

    abstract:BACKGROUND:It is known from clinical practice and observational studies that elderly patients with a diagnosis of inflammatory rheumatic diseases (IRD) bear a significantly increased risk for cardiovascular diseases such as coronary artery disease (CAD) and heart failure. The molecular mechanism, however, is still not ...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000471763

    authors: Bruton M,Hollan I,Xiao J,Lindroos E,Mikkelsen K,Rynning SE,Saatvedt K,Almdahl SM,Harris HE,Lundberg IE,Wick C

    更新日期:2017-01-01 00:00:00

  • Decline of vertical gaze and convergence with aging.

    abstract:BACKGROUND:Disturbance of vertical eye movement and ocular convergence is often observed in elderly people, but little is known about its frequency. OBJECTIVE:The purpose of this study was to investigate age-associated changes in vertical eye movement and convergence in healthy elderly people, using a digital video ca...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000076777

    authors: Oguro H,Okada K,Suyama N,Yamashita K,Yamaguchi S,Kobayashi S

    更新日期:2004-05-01 00:00:00

  • Effects of Movement-Based Mind-Body Interventions on Physical Fitness in Healthy Older Adults: A Meta-Analytical Review.

    abstract:INTRODUCTION:Declines in physical fitness can notably affect healthy aging of older adults. Multimodal exercise training regimen such as mind-body interventions (MBIs) has been reported to mitigate these aging-related declines of physical function. This meta-analytical review aimed at pooling the effects of MBIs on phy...

    journal_title:Gerontology

    pub_type: meta分析

    doi:10.1159/000512675

    authors: Ebner SA,Meikis L,Morat M,Held S,Morat T,Donath L

    更新日期:2021-01-27 00:00:00