Correlation between carotid blood flow and brain atrophy in patients with multi-infarct dementia.

abstract：:The eukaryotic stress response involves translational suppression of non-housekeeping proteins and the sequestration of unnecessary mRNA transcripts into stress granules (SGs). This process is dependent on mRNA-binding proteins (RBPs) that interact with capped mRNA transcripts through RNA recognition motifs, and exhib...

journal_title：Gerontology

authors： Vanderweyde T,Youmans K,Liu-Yesucevitz L,Wolozin B

更新日期：2013-01-01 00:00:00

abstract：:A trypsin-type protease was purified to enzymatic homogeneity from human umbilical vein endothelial cells by sequential affinity chromatographies. The enzyme specifically hydrolyzed dibasic substrates with leucine at the P3 positions, but scarcely hydrolyzed the other substrates tested. The enzyme was strongly inhibit...

journal_title：Gerontology

authors： Kido H,Takeda M,Wakabayashi H,Tanaka S,Nishimura N,Takenaka M,Okada M

更新日期：1993-01-01 00:00:00

abstract：:Both ageing and vitamin C (VC) deficiency result in immune defect. Since low serum and tissue levels of VC are found in the elderly, we have in a placebo-controlled study, tested the effect of VC supplements (500 mg/day i.m. for 1 month) on various immune parameters. Indeed, VC enhances the proliferative response of T...

journal_title：Gerontology

authors： Kennes B,Dumont I,Brohee D,Hubert C,Neve P

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Functional status in older people is a dynamic situation, which makes it necessary to evaluate functional capacity at different times to determinate their prognostic value. OBJECTIVE:To examine the association between functional status (baseline and change after acute illness) and mortality and functional c...

journal_title：Gerontology

authors： Baztán JJ,Gálvez CP,Socorro A

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The identification of modifiable health span-promoting factors is a public health priority. OBJECTIVE:To explore the socio-environmental, lifestyle, behavioural, and psychological determinants of a clinical phenotypic measure of biological ageing in the Singapore Longitudinal Ageing Study (SLAS) cohort. ...

journal_title：Gerontology

authors： Ng TP,Zhong X,Gao Q,Gwee X,Chua DQL,Larbi A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Due to aging, tissue regeneration gradually declines. Contemporary strategies to promote tissue-specific regeneration, in particular in elderly patients, often include synthetic material apt for implantation primarily aiming at upholding body functions and regaining appropriate anatomical and functional inte...

journal_title：Gerontology

authors： Schimke MM,Paul S,Tillmann K,Lepperdinger G,Stigler RG

更新日期：2019-01-01 00:00:00

abstract：:The experimental evidence is reviewed which bears on the theory that aging in mammalian cells may be related to a decline in the efficiency of normal DNA repair processes. Although the data are as yet fragmentary, they do suggest that there is an age-associated decline in the capacity of cells to perform at least cert...

journal_title：Gerontology

authors： Little JB

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:In Germany, there is an ongoing concern about the high prevalence of underweight on admission to health-care institutions. In order to assess possible sex-specific differences, the aim of this study is to provide valid figures about the prevalence and risk factors of underweight of men and women in German nur...

journal_title：Gerontology

authors： Strube-Lahmann S,Müller-Werdan U,Norman K,Skarabis H,Lahmann NA

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:The leading causes of death and disability in the elderly are from cardiovascular and cerebrovascular diseases. The biological role of stem cells in the hematopoietic system has been well characterized and has led to the development of hematopoietic stem and progenitor cell (HSPC) transplantation for the tre...

journal_title：Gerontology

authors： Williams BA,Keating A

更新日期：2008-01-01 00:00:00

abstract：:One of the problems associated with using random-source dogs to study in vivo vascular responses is their unknown background. Since aging is known to influence vascular responses, unknown variations in age could influence experimental results. The vast majority of aging studies examine arteries in vitro. This study wa...

journal_title：Gerontology

authors： Kaiser L,Ptu S

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Although foot pain has been linked to fall risk, contributions of pain severity, foot posture, or foot function are unclear. These factors were examined in a cohort of older adults. OBJECTIVE:The purpose of this study was to examine the associations of foot pain, severity of foot pain, and measures of foot ...

journal_title：Gerontology

authors： Awale A,Hagedorn TJ,Dufour AB,Menz HB,Casey VA,Hannan MT

更新日期：2017-01-01 00:00:00

abstract：:Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...

journal_title：Gerontology

authors： Peng MT,Hsü HK

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Cardiac surgery is widely believed to be an excessively high-risk intervention for very elderly patients with coronary artery or valvular disease. However, as life expectancy and the prospect of sustained quality of life into older age increase, this assumption should be challenged so that surgery is not den...

journal_title：Gerontology

authors： Guilfoyle MR,Drain AJ,Khan A,Ferguson J,Large SR,Nashef SA

更新日期：2010-01-01 00:00:00

abstract：:The effect of age on the compositional analysis of human Descemet's membrane was examined. Membranes were obtained from human corneas ranging from 0.5 to 95 years and purified by sodium dodecyl sulfate (SDS) extraction. Substantial age-related changes were obtained in the amino acid compositions of the SDS-insoluble b...

journal_title：Gerontology

authors： Freeman IL,Vergnes JP,Brown SI

更新日期：1980-01-01 00:00:00

abstract：:Hyposplenism has been reported in elderly people. However, from previous studies, it was not clear whether the observed alterations in splenic function were a physiologic effect of advanced age itself or a consequence of age-related diseases. As hyposplenism is believed to predispose to infections, autoimmune phenomen...

journal_title：Gerontology

authors： Ravaglia G,Forti P,Biagi F,Maioli F,Boschi F,Corazza GR

更新日期：1998-01-01 00:00:00

abstract：:Age-related changes of muscle fiber and collagen content of the diaphragm (DIA) and rectus abdominis (RA) muscles were examined in rats aged 1, 4, 8 and 18 months. The cross-sectional areas of all muscle fiber types (I, IIa, IIb) and the amount of collagen in both DIA and RA increased up to the age of 8 months after w...

journal_title：Gerontology

authors： Rodrigues CJ,Rodrigues Júnior AJ,Bohm GM

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Understanding comorbidity prevalence and the effects of comorbidities in older veterans with lower extremity amputations may aid in assessing patient outcomes, resource use, and facility-level quality of care. OBJECTIVES:To determine the degree to which adding outpatient to inpatient administrative data sou...

journal_title：Gerontology

authors： Kurichi JE,Stineman MG,Kwong PL,Bates BE,Reker DM

更新日期：2007-01-01 00:00:00

abstract：:Research into the aetiology of osteoarthritis has for several decades been concentrated on the destruction of the articular cartilage, the initiating events being believed to be changes in the proteoglycans and subsequently in the supporting collagenous framework, whereafter the disease is irreversible. Recent evidenc...

journal_title：Gerontology

authors： Bailey AJ,Mansell JP

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Wheelchairs are frequently prescribed for residents with mobility impairments in long-term care. Many residents receive poorly fitting wheelchairs, compromising functional independence and mobility, and contributing to subsequent health issues such as pressure ulcers. The extent of this problem and the facto...

journal_title：Gerontology

authors： Giesbrecht EM,Mortenson WB,Miller WC

更新日期：2012-01-01 00:00:00

abstract：:Older adults often face challenges as they transition out of the acute care hospital, especially with regard to adhering to their medications. In this narrative review, we discuss medication adherence in older adults across the continuum of care, describing reasons for nonadherence, methods to assess adherence and too...

journal_title：Gerontology

authors： Mixon AS,Neal E,Bell S,Powers JS,Kripalani S

更新日期：2015-01-01 00:00:00

abstract：:Walking and other physical activities were studied in a representative population sample of 619 70-year-old people in the city of Gothenburg, Sweden. Walking was the most common physical activity declared, and two thirds of those without an obvious disability walked 30 min or more every day. Subjects who took a daily ...

journal_title：Gerontology

authors： Frändin K,Grimby G,Mellström D,Svanborg A

更新日期：1991-01-01 00:00:00

abstract：:We have shown that ultrastructural changes accompany ageing in the human fetal lung fibroblast strain MRC-5. In order to further characterise these changes a method has been devised to prepare subcellular fractions from MRC-5 fibroblasts using a discontinous gradient of metrizamide preceded by a low-speed centrifugati...

journal_title：Gerontology

authors： Shakespeare VA,Buchanan JH

更新日期：1979-01-01 00:00:00

abstract：:The effect of ageing on the threshold firing rate of motor units from the first dorsal interosseous muscle was investigated. Two groups of 9 healthy male subjects between the ages of 20-29 and 60-69 years took part in the study. The threshold firing rate of motor units in young subjects showed close agreement with pre...

journal_title：Gerontology

authors： Newton JP,Yemm R,McDonagh MJ

更新日期：1988-01-01 00:00:00

abstract：:The article discusses some aspects demonstrating that a decrease in acetylcholine synthesis in senile dementia of the Alzheimer type (SDAT) is a consequence of the strong decline in glucose turnover in the brain. This becomes obvious by the fact that acetylcoenzyme A, the key substrate of acetylcholine synthesis, is e...

journal_title：Gerontology

authors： Meier-Ruge W,Bertoni-Freddari C,Iwangoff P

更新日期：1994-01-01 00:00:00

abstract：:Neurofilament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer's disease. The abnormally proliferated neurofilament was characterized by immunostaining and electron microscopy. The intracytoplasmic neurofilament ...

journal_title：Gerontology

authors： Takeda M,Nishimura T,Kudo T,Tanimukai S,Gotow T,Tanabe H,Miki T,Nakamura Y,Niigawa H,Morita H

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Adults aged 65 years and older stand to benefit from the accumulating wealth of Internet-based health resources, including online interventions to assist in the self-management of chronic health conditions. However, concerns have been expressed that lesser Internet use and familiarity among older adults may ...

journal_title：Gerontology

authors： Crabb RM,Rafie S,Weingardt KR

更新日期：2012-01-01 00:00:00

abstract：:Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional altera...

journal_title：Gerontology

authors： Wang M,Monticone RE,Lakatta EG

更新日期：2014-01-01 00:00:00

abstract：:Antinuclear antibodies, anticardiolipin antibodies and IgM rheumatoid factor were determined in 300 healthy aged subjects, comparing their prevalence to that in 100 healthy subjects aged between 19 and 44 years and 352 patients under 65 years of age, affected by various systemic rheumatic diseases. Increased productio...

journal_title：Gerontology

authors： Ruffatti A,Rossi L,Calligaro A,Del Ross T,Lagni M,Marson P,Todesco S

更新日期：1990-01-01 00:00:00

abstract：AIM:To investigate acceptance and usage issues in relation to Telehealth products as used by frail older clients of the Transition Care Program and their carers. METHOD:The study design was a quasi-randomised controlled clinical trial. A stratified random sample of participants was allocated to one of five groups usin...

journal_title：Gerontology

authors： Wade R,Shaw K,Cartwright C

更新日期：2012-01-01 00:00:00

abstract：:To investigate the mechanisms of age-related decline in synthesis of adrenal androgen, we studied the contents of cortisol (F) and dehydroepiandrosterone (DHEA) and the amounts of cytochrome P450 17 alpha-hydroxylase (P450c17) mRNA and cytochrome P450 11 beta-hydroxylase (P450c11) mRNA in young (1 year old) and senesc...

journal_title：Gerontology

authors： Ogo A,Haji M,Ohashi M,Nawata H

更新日期：1991-01-01 00:00:00