Abstract:
:Glutamine synthetase (GS) activity was measured in whole brain, different brain areas, liver and heart of 23- to 26-month-old rats, and then compared to matched animals of 3 months. A significant increase of GS activity was found in whole brain (25%) of old rats, as well as in all brain areas studied, but particularly in midbrain (36%), hypothalamus (32%), brainstem (32%), striatum (27%) and cerebellum (22%). A significant decrease of GS activity (21%) was found in liver and no significant difference in heart of old rats when compared to matched animals of 3 months. The present results suggest that an increase of GS activity in brain of old rats may be an adaptive phenomenon, and the regulatory mechanisms for GS with increasing age are different, depending on the tissues.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Cao Danh H,Strolin Benedetti M,Dostert Pdoi
10.1159/000212686subject
Has Abstractpub_date
1985-01-01 00:00:00pages
95-100issue
2eissn
0304-324Xissn
1423-0003journal_volume
31pub_type
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