Alkylation damage and repair in Alzheimer's disease lymphocytes.

abstract：:Lymphopenia is a common finding in old people admitted to medical and psychiatric wards. We describe a pilot study of the clinical associations, and prognostic significance of lymphopenia in elderly persons admitted to acute medical and psychiatric wards. Consecutive patients admitted to acute medical and psychiatric ...

journal_title：Gerontology

authors： Dennis MS,Nicolson A,Lehmann AB,Junaid O,Byrne EJ,Hopkinson N

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:Declines in physical fitness can notably affect healthy aging of older adults. Multimodal exercise training regimen such as mind-body interventions (MBIs) has been reported to mitigate these aging-related declines of physical function. This meta-analytical review aimed at pooling the effects of MBIs on phy...

journal_title：Gerontology

authors： Ebner SA,Meikis L,Morat M,Held S,Morat T,Donath L

更新日期：2021-01-27 00:00:00

abstract：:We performed 24-hour ambulatory electrocardiographic (Holter) examinations in 50 retired hospital workers (30 men, 20 women), aged 58-85 years (mean age +/- SD: 65.9 +/- 4.6 years), with a normal clinical history, physical examination and baseline ECG. There was a significant difference between daytime and nocturnal m...

journal_title：Gerontology

authors： Ribera JM,Cruz AJ,Zamorano JL,Pérez-Casar F

更新日期：1989-01-01 00:00:00

abstract：:The effects of long-term cigarette smoking on regional cerebral blood flow (rCBF) were studied in 67 normal male volunteers. All subjects were healthy volunteers without any past history of cerebral and pulmonary disease. rCBF decreased significantly with advancing age. Although there was no significant difference in ...

journal_title：Gerontology

authors： Yamashita K,Kobayashi S,Yamaguchi S,Kitani M,Tsunematsu T

更新日期：1988-01-01 00:00:00

abstract：:Form birefringence curves and linear dichroic properties of aging rat tendons are different from those of adult controls. The steepness of the form birefringence curves and the increased retardations found in aging tendons are ascribed to an increase in collagen aggregation accompanied by loss of tissue water. Based o...

journal_title：Gerontology

authors： Mello ML,Vidal BC,de Carvalho AC,Caseiro-Filho AC

更新日期：1979-01-01 00:00:00

abstract：:Anion exchange (AE) proteins are present in human neurons in the brain. Immunohistochemical data indicate that their apparent expression level increases with age, and especially with degeneration in Alzheimer's disease-affected brain areas. The increase in immunoreactivity is probably caused by changes in AE structure...

journal_title：Gerontology

authors： Bosman GJ,Renkawek K,Van Workum FP,Bartholomeus IG,De Grip WJ

更新日期：1997-01-01 00:00:00

abstract：:Aging is associated with far-reaching changes in physiological functions resulting in morbidity and ultimately death. Age-related frailty, insecurity and reduced physical activity contribute to a progressive loss of muscle mass and function, commonly referred to as sarcopenia. Due to the increase in life expectancy in...

journal_title：Gerontology

authors： Arnold AS,Egger A,Handschin C

更新日期：2011-01-01 00:00:00

abstract：:Alloxan diabetes in Swiss mice of both sexes accelerated the ageing of collagen in newly formed cotton pellet granuloma concomitant with its similar effect on dorsal skin. The degree of response of collagen to alloxanization was dependent on the duration of the treatment and the sex of the animal. It is suggested that...

journal_title：Gerontology

authors： Behera HN,Patnaik BK

更新日期：1981-01-01 00:00:00

abstract：:The interactions of ergot alkaloids and of other drugs with dopamine (DA) and alpha-adrenergic receptors were investigated. The tested ergot alkaloids inhibit synaptosomal tyrosine hydroxylase activity and reverse the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Thus, ergot alkaloids ...

journal_title：Gerontology

authors： Goldstein M,Lew JY,Hata F,Lieberman A

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Orthostatic hypotension (OH) is common in older adults and associated with increased morbidity and mortality, loss of independence and high health-care costs. Standing up slowly is a recommended non-pharmacological intervention. However, the effectiveness of this advice has not been well studied. OBJECTIVES...

journal_title：Gerontology

authors： de Bruïne ES,Reijnierse EM,Trappenburg MC,Pasma JH,de Vries OJ,Meskers CG,Maier AB

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Diabetes is common in elderly persons and is highly prevalent in Mexican Americans. Little is known about factors associated with the incidence of diabetes complications. OBJECTIVE:To examine the social, demographic and health factors associated with a 7-year incidence of diabetes complications among older ...

journal_title：Gerontology

authors： Kaushik VP,Al Snih S,Ray LA,Raji MA,Markides KS,Goodwin JS

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Future time perspective has been associated with subjective well-being, though depending on the line of research considered either an open-ended future time perspective or a limited future time perspective has been associated with high well-being. Most of this research however has conceptualized future time ...

journal_title：Gerontology

authors： Kozik P,Hoppmann CA,Gerstorf D

更新日期：2015-01-01 00:00:00

abstract：:The 'use it or lose it' hypothesis of cognitive aging predicts that engagement in intellectual, social, and physical activities offers protective benefits from age-related cognitive decline and lowers dementia risk. Although this hypothesis has not yet been supported conclusively, there is some empirical evidence in f...

journal_title：Gerontology

authors： Bielak AA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Old age has traditionally been considered to begin at age 65. The improving health and functional status observed among older people may necessitate reevaluation of this cut-off point. OBJECTIVE:To present the changing prevalence of common geriatric syndromes, functional parameters, common disease status an...

journal_title：Gerontology

authors： Jacobs JM,Maaravi Y,Cohen A,Bursztyn M,Ein-Mor E,Stessman J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:There is concern that people living in residential care in Australia make significant and often inappropriate use of acute in-patient hospital services. To date, no factual information has been collected in Australia and its absence may allow myths and negative stereotypes to proliferate. OBJECTIVE:To deter...

journal_title：Gerontology

authors： Finucane P,Wundke R,Whitehead C,Williamson L,Baggoley C

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Mild-to-moderate chronic kidney disease (CKD G3a) is prevalent in older adults. Substantial evidence suggests that individuals with advanced CKD face a high risk for common geriatric conditions, like functional impairment and cognitive decline, whereas the relationships between mild-to-moderate CKD and funct...

journal_title：Gerontology

authors： König M,Gollasch M,Spira D,Buchmann N,Hopfenmüller W,Steinhagen-Thiessen E,Demuth I

更新日期：2018-01-01 00:00:00

abstract：:The life span of Drosophila melanogaster was reduced when copper compounds were fed at concentrations of 1 X 10(-3) M or greater. Feeding lower concentrations of copper compounds failed to significantly change life span. A combination of copper gluconate and gluconic acid increased the adult life span by 21.6%. We con...

journal_title：Gerontology

authors： Massie HR,Williams TR,Aiello VR

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Werner's syndrome, a rare autosomal recessive disorder, is characterized by features of premature aging. Seventy-five percent of the alleles of Japanese patients with Werner's syndrome have one of three major mutations. OBJECTIVE:To determine the genotype of a patient with Werner's syndrome. METHODS:We dia...

journal_title：Gerontology

authors： Nakayama T,Ochiai T,Takahashi Y,Ohkubo K,Hironaga T,Kokubun S

更新日期：2002-07-01 00:00:00

abstract：:The conditioned avoidance response and the cerebral levels of dopamine and noradrenaline have been studied in control rats and in rats submitted to a hypobaric hypoxia. A protection against the effects of hypoxia was induced by both dihydroergocornine (20 microgram/kg) and dihydroergocryptine (100 microgram/kg), and t...

journal_title：Gerontology

authors： Boismare F,Le Poncin M,Lefrançois J

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Previous extensive clinical studies, using angiography or ultrasound, investigated the influence of alimentary, medicamentous and other antiatherosclerotic measures on the degree of atherosclerosis. The following signs of regression were found: clinical improvement, changes in tonus of vascular walls, format...

journal_title：Gerontology

authors： Kunz J

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:To explore predictors of functional improvement or decline in instrumental activities of daily living (IADL) among community-dwelling older people. METHODS:Of all the residents (>or=65 years, n = 1,673) living in Yoita town, Niigata prefecture, Japan, in 2000, 1,544 subjects who participated in the baseline...

journal_title：Gerontology

authors： Fujiwara Y,Yoshida H,Amano H,Fukaya T,Liang J,Uchida H,Shinkai S

更新日期：2008-01-01 00:00:00

abstract：:Fishes exhibit a 'determinate' type of growth in short-lived species of warmer regions and an 'indeterminate' type in long-lived species of colder regions. Growth is measured in units of length and weight and is best represented as the specific growth rate. The relationship between weight and length provides an index ...

journal_title：Gerontology

authors： Dutta H

更新日期：1994-01-01 00:00:00

abstract：:Aging is associated with a decline in renal concentrating ability in response to dehydration-induced arginine vasopressin (AVP) release. To examine target tissue sensitivity, cortical collecting tubules (CCT) were individually microdissected from young (3 months), middle-aged (2-3 years) and old (4-5.5 years) rabbits ...

journal_title：Gerontology

authors： Wilson PD,Dillingham MA

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial. It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome. OBJECTIVE:The purpose of this study was to determine whether age in...

journal_title：Gerontology

authors： Wakabayashi I

更新日期：2012-01-01 00:00:00

abstract：:Although it is usually assumed that Lamarckian inheritance does not and cannot occur, molecular mechanisms by which non-mutational changes acquired in one generation can be transmitted to the next are now known. These mechanisms involve changes in chromatin structure, rather than changes in DNA base sequence. It is ar...

journal_title：Gerontology

authors： Jablonka E,Lamb MJ

更新日期：1990-01-01 00:00:00

abstract：:We examined the presenting features, clinical course and prognosis in relation to age in 121 patients with primary biliary cirrhosis (PBC) for a mean follow-up of 4.6 years. 35 patients (29%) were over age 65 years at presentation/detection. There was a higher proportion of patients asymptomatic of liver disease in th...

journal_title：Gerontology

authors： Lehmann AB,Bassendine MF,James OF

更新日期：1985-01-01 00:00:00

abstract：:The concentrations of noradrenaline and adrenaline were studied in specimens of the posterior tibial artery obtained from 18 subjects at postmortem examination. The mean noradrenaline concentration was 167 ng/g artery (range 17-449 ng/g) and the mean adrenaline concentration was 5 ng/g (range 0--21 ng/g). There was no...

journal_title：Gerontology

authors： Neubauer B,Christensen NJ

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Malnutrition is a widespread but largely unrecognized problem in aged patients, more so as it is a contributing factor to the increased morbidity and mortality in this age group. Since direct measurements of body composition are not possible in a large number of patients, good anthropometric reference data a...

journal_title：Gerontology

authors： Bonnefoy M,Jauffret M,Kostka T,Jusot JF

更新日期：2002-05-01 00:00:00

abstract：:The concentration of malonaldehyde (MDA) was measured in human erythrocytes obtained from subjects suffering from senile dementia of the Alzheimer type (SDAT), non-demented elderly subjects, and from young controls by two methods: high-performance liquid chromatography (HPLC) and the thiobarbituric acid (TBA) test. Th...

journal_title：Gerontology

authors： Bermejo P,Gómez-Serranillos P,Santos J,Pastor E,Gil P,Martín-Aragón S

更新日期：1997-01-01 00:00:00

abstract：:Aging is a complex biological phenomenon which involves progressive loss of different physiological functions of various tissues of living organisms. It is the inevitable fate of life and is a major risk factor for death and different pathological disorders. Based on a wide variety of studies performed in humans as we...

journal_title：Gerontology

authors： Chakravarti B,Chakravarti DN

更新日期：2007-01-01 00:00:00