Abstract:
:Lymphopenia is a common finding in old people admitted to medical and psychiatric wards. We describe a pilot study of the clinical associations, and prognostic significance of lymphopenia in elderly persons admitted to acute medical and psychiatric wards. Consecutive patients admitted to acute medical and psychiatric wards were prospectively selected according to initial peripheral lymphocyte count (PLC) into lymphopenic (PLC < 1.0 X 10(9)/litre, n = 41), and non-lymphopenic (PLC > 1.5 x 10(9)/litre, n = 23). Results of routine haematological and biochemical investigations were recorded, as well as drug history and medical diagnoses. Anthropometric measurements, assessment of functional ability (Barthel ADL Index), and cognitive function (Mini-Mental State Examination) were then performed by investigators blind to lymphocyte status. Patients were contacted between 3 and 6 months following recruitment into the study. Lymphopenia was associated with functional ability as measured by a lower Barthel score (p = 0.004), and cognitive impairment as measured by the Mini-Mental State Examination (p = 0.02). No association was found with medical diagnostic groupings, drugs known to cause lymphopenia, nutritional status, or survival. Lymphopenia may be a significant marker of vulnerability, and a larger study is required to elucidate the veracity and mechanisms of lymphopenia-associated debility.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Dennis MS,Nicolson A,Lehmann AB,Junaid O,Byrne EJ,Hopkinson Ndoi
10.1159/000022003subject
Has Abstractpub_date
1998-01-01 00:00:00pages
168-71issue
3eissn
0304-324Xissn
1423-0003pii
ger44168journal_volume
44pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract:BACKGROUND:Constipation and lower urinary tract symptoms (LUTS) very frequently occur in the elderly, and several reports have suggested that dysfunction in either one of these systems may affect the other. Most studies correlating rectal and bladder dysfunction, however, have been carried out in children or young wome...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000052776
更新日期:2001-03-01 00:00:00
abstract::The prevalence of and risk factors for varicose veins (VV) were studied in elderly persons over 60 years of age who had visited the Tonya and Farabi Hospitals in Trabzon, a city in northeastern Turkey. VV were defined as dilated, tortuous and elongated veins of the lower extremities and were classified into four types...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213571
更新日期:1994-01-01 00:00:00
abstract::Measurements of total exchangeable potassium and total exchangeable sodium, total body water and extracellular fluid volumes were made in 69 patients aged 30-90+ years, using multiple isotope techniques. The patients were not suffering from any chronic disorder or having potassium or diuretic therapy and were consider...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212495
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Adults aged 65 years and older stand to benefit from the accumulating wealth of Internet-based health resources, including online interventions to assist in the self-management of chronic health conditions. However, concerns have been expressed that lesser Internet use and familiarity among older adults may ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000329340
更新日期:2012-01-01 00:00:00
abstract::We use nerve tissue cultures as a model system for studying the mode of action of centrally acting drugs. Neurons in cerebellar cultures retain a number of organ-specific properties including the formation of complex synaptic networks and characteristic bioelectric activity. Electrical activity may be recorded from Pu...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212300
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Although a relationship between diet and mortality is well recognized, there is little information on the extent to which different food sources contribute to survival in elderly people. OBJECTIVE:To examine the effect of individual food groups on mortality in institutionalized elderly people from Asturias ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000135069
更新日期:2008-01-01 00:00:00
abstract::The glucose uptake of lizard brain slices decreased between young and middle-aged groups. There was a significant increase in the parameter between the middle-aged and old-age groups. Cold shock induced a decrease in glucose uptake of brain slices in the old, with no appreciable effect in the young and middle aged. ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213005
更新日期:1989-01-01 00:00:00
abstract::100 consecutive endoscopies in elderly patients referred with symptoms after previous gastric surgery are reviewed. 57% showed positive findings, and the procedure was found particularly useful in making definitive diagnoses in patients presenting with dyspepsia and upper gastro-intestinal bleeding. The incidence of g...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212699
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Orthostatic hypotension (OH) is common in older adults and associated with increased morbidity and mortality, loss of independence and high health-care costs. Standing up slowly is a recommended non-pharmacological intervention. However, the effectiveness of this advice has not been well studied. OBJECTIVES...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000450642
更新日期:2017-01-01 00:00:00
abstract::The effect of age on the compositional analysis of human Descemet's membrane was examined. Membranes were obtained from human corneas ranging from 0.5 to 95 years and purified by sodium dodecyl sulfate (SDS) extraction. Substantial age-related changes were obtained in the amino acid compositions of the SDS-insoluble b...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212417
更新日期:1980-01-01 00:00:00
abstract::The effect of ageing on the threshold firing rate of motor units from the first dorsal interosseous muscle was investigated. Two groups of 9 healthy male subjects between the ages of 20-29 and 60-69 years took part in the study. The threshold firing rate of motor units in young subjects showed close agreement with pre...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212939
更新日期:1988-01-01 00:00:00
abstract::The concentration of malonaldehyde (MDA) was measured in human erythrocytes obtained from subjects suffering from senile dementia of the Alzheimer type (SDAT), non-demented elderly subjects, and from young controls by two methods: high-performance liquid chromatography (HPLC) and the thiobarbituric acid (TBA) test. Th...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213853
更新日期:1997-01-01 00:00:00
abstract::We have shown that ultrastructural changes accompany ageing in the human fetal lung fibroblast strain MRC-5. In order to further characterise these changes a method has been devised to prepare subcellular fractions from MRC-5 fibroblasts using a discontinous gradient of metrizamide preceded by a low-speed centrifugati...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212358
更新日期:1979-01-01 00:00:00
abstract::Differences between women and men in terms of gender gaps at late stages of their lives are the focus of this mini-review. We approach the matter by taking up the position of complex yet promising standpoints, the bio-psycho-social perspective on the one hand and approaches of developmental psychology on the other. Li...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000323154
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:It is known that growth factors play a role in ageing and atherogenesis, and insulin develops mitogenic activity in vitro. OBJECTIVES:This study focuses on the pathway by which insulin induces proliferation and mobility in vascular smooth muscle cells (SMCs) compared with that of insulin-like growth factor-...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000085118
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Lying on the floor for a long time after falls, regardless of whether an injury results, remains an unsolved health care problem. In order to develop efficient and acceptable fall detection and reaction approaches, it is relevant to improve the understanding of the circumstances and the characteristics of po...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000478092
更新日期:2018-01-01 00:00:00
abstract::This review focuses on 3 allergic disorders of persons coming up against venerable age: asthma, allergic rhinitis, and atopic dermatitis. The prevalence of allergic diseases in the elderly ranges from 5 to 10% and appears to be rising. A gradual decline in immune function, termed immunosenescence, and age-related chan...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000355307
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Depressed mood may either precede mobility limitation or follow from mobility limitation. OBJECTIVE:To compare mood status among people with manifest mobility limitation, those with preclinical mobility limitation and those without mobility limitation and investigate factors explaining the association betwe...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000098416
更新日期:2007-01-01 00:00:00
abstract::To evaluate the requirement for provocative cystometry in urodynamic investigation in the elderly with urinary incontinence, 100 consecutive patients, who were referred on the basis of defined clinical criteria, were first studied by supine cystometry followed by provocative tests where necessary. The most satisfactor...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212791
更新日期:1986-01-01 00:00:00
abstract::Alloxan diabetes in Swiss mice of both sexes accelerated the ageing of collagen in newly formed cotton pellet granuloma concomitant with its similar effect on dorsal skin. The degree of response of collagen to alloxanization was dependent on the duration of the treatment and the sex of the animal. It is suggested that...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212475
更新日期:1981-01-01 00:00:00
abstract::The pharmacokinetics of indomethacin (Indo) was studied in 10 healthy elderly male volunteers (age 67-81 years) following the oral administration of a single 75-mg dose of a sustained release form of Indo. The total and free plasma and erythrocyte concentrations of Indo were determined by a specific high-pressure liqu...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212802
更新日期:1986-01-01 00:00:00
abstract::The biological rhythms of rectal temperature were documented in young (circadian variations) and elderly (circadian and seasonal variations) human subjects either in apparent good health or suffering from senile dementia of Alzheimer type (SDAT). All the subjects were synchronized. Data obtained showed a decrease of t...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212774
更新日期:1986-01-01 00:00:00
abstract::Both ageing and vitamin C (VC) deficiency result in immune defect. Since low serum and tissue levels of VC are found in the elderly, we have in a placebo-controlled study, tested the effect of VC supplements (500 mg/day i.m. for 1 month) on various immune parameters. Indeed, VC enhances the proliferative response of T...
journal_title:Gerontology
pub_type: 临床试验,杂志文章
doi:10.1159/000213131
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Being able to rise from a chair is an important daily life activity that requires sufficient lower extremity muscle power and postural control. OBJECTIVE:To assess the effects of an individually tailored intervention on the chair rise capacity of active and inactive community-dwelling older men and women. ...
journal_title:Gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000347197
更新日期:2013-01-01 00:00:00
abstract::In mammals, aging is often viewed as a progressive decline in physiological competence with a corresponding inability to adapt to stressful stimulation. Several current theories of aging have implicated the sympathetic nervous system in many of the metabolic, cardiovascular and behavior changes which attend advancing ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212785
更新日期:1986-01-01 00:00:00
abstract::Aging researchers have long been interested in understanding individuals' subjective perceptions of their own memory functioning. Previous research has shown that subjective memory ratings are partly based on memory performance but also reflect the influence of other factors, such as depressive symptoms. The aim of th...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000369010
更新日期:2015-01-01 00:00:00
abstract::Paraneoplastic symptoms, caused by a malignancy, but not directly related to invasion by the tumor or its metastases, are the result of a wide variety of tumor-derived biologic mediators like hormones, peptides, antibodies, cytotoxic lymphocytes, autocrine and paracrine mediators. Systemic inflammatory rheumatic disea...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000314634
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:BACKGROUND; The link between experiencing difficulties in reading or understanding and non-compliance with drug treatment among seniors is not clearly established. OBJECTIVES:We measured the effect of both difficulties in reading, as well as difficulties in understanding prescription labelling, on non-compl...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000048924
更新日期:2002-01-01 00:00:00
abstract::Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulat...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000371845
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Malnutrition is a widespread but largely unrecognized problem in aged patients, more so as it is a contributing factor to the increased morbidity and mortality in this age group. Since direct measurements of body composition are not possible in a large number of patients, good anthropometric reference data a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000052836
更新日期:2002-05-01 00:00:00