Evidence for increased proteolytic activity in ageing human fibroblasts.

abstract：BACKGROUND:Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. OBJECTIVE:To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and fr...

journal_title：Gerontology

authors： Arrieta H,Hervás G,Rezola-Pardo C,Ruiz-Litago F,Iturburu M,Yanguas JJ,Gil SM,Rodriguez-Larrad A,Irazusta J

更新日期：2019-01-01 00:00:00

abstract：:A trypsin-type protease was purified to enzymatic homogeneity from human umbilical vein endothelial cells by sequential affinity chromatographies. The enzyme specifically hydrolyzed dibasic substrates with leucine at the P3 positions, but scarcely hydrolyzed the other substrates tested. The enzyme was strongly inhibit...

journal_title：Gerontology

authors： Kido H,Takeda M,Wakabayashi H,Tanaka S,Nishimura N,Takenaka M,Okada M

更新日期：1993-01-01 00:00:00

abstract：:The effects of ovine corticotropin releasing factor (o-CRF) on the secretions of ACTH, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were studied in the healthy young and elderly male individuals. o-CRF caused significant elevations of plasma ACTH, cortisol and DHEA concentrations...

journal_title：Gerontology

authors： Ohashi M,Fujio N,Kato K,Nawata H,Ibayashi H

更新日期：1986-01-01 00:00:00

abstract：:Although common among the hospitalized frail elderly, malnutrition is often unrecognized by clinicians, and its identification is fought with difficulty due to inadequate nutritional assessment methods and standards. This study compared the use of percent ideal body weight (%IBW) and anthropometry in the assessment of...

journal_title：Gerontology

authors： Lansey S,Waslien C,Mulvihill M,Fillit H

更新日期：1993-01-01 00:00:00

abstract：:The 'use it or lose it' hypothesis of cognitive aging predicts that engagement in intellectual, social, and physical activities offers protective benefits from age-related cognitive decline and lowers dementia risk. Although this hypothesis has not yet been supported conclusively, there is some empirical evidence in f...

journal_title：Gerontology

authors： Bielak AA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Dual-task-based assessment tests failed to establish a dependable relationship between dual-task-related gait changes and the risk of falls in the elderly. OBJECTIVE:The aim of this study was to examine whether changes in gait while counting backward could be associated with the occurrence of a first fall a...

journal_title：Gerontology

authors： Beauchet O,Allali G,Annweiler C,Berrut G,Maarouf N,Herrmann FR,Dubost V

更新日期：2008-01-01 00:00:00

abstract：:Recently, Granacher et al. (2010) proposed an intergenerational approach to promoting balance and strength for fall prevention in children and elderly subjects together. Although this sounds like a stimulating idea, its effectiveness for fall prevention in both groups has yet to be demonstrated. Undoubtedly, fall prev...

journal_title：Gerontology

authors： Burtscher M,Kopp M

更新日期：2011-01-01 00:00:00

abstract：:This review focuses on 3 allergic disorders of persons coming up against venerable age: asthma, allergic rhinitis, and atopic dermatitis. The prevalence of allergic diseases in the elderly ranges from 5 to 10% and appears to be rising. A gradual decline in immune function, termed immunosenescence, and age-related chan...

journal_title：Gerontology

authors： Milgrom H,Huang H

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:One of the earliest and most persistent inquiries in developmental psychology is that of the relative contributions of nature and nurture to human ontogeny. One way of studying this distinction is by doing cross-cultural studies, in which culture provides a powerful way to operationalize the influence of nur...

journal_title：Gerontology

authors： Luszcz M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:It is known that growth factors play a role in ageing and atherogenesis, and insulin develops mitogenic activity in vitro. OBJECTIVES:This study focuses on the pathway by which insulin induces proliferation and mobility in vascular smooth muscle cells (SMCs) compared with that of insulin-like growth factor-...

journal_title：Gerontology

authors： Ruiz-Torres A,Lozano R,Melón J,Carraro R

更新日期：2005-07-01 00:00:00

abstract：:Cell surface of chick fibroblasts were labelled by a short treatment with 125I in presence of lactoperoxidase. A glycoprotein (220,000 molec. wt) was iodinated and was present in a more exposed position or in greater amounts at the surface of old phase III cells compared to young phase II cells. The findings extend ou...

journal_title：Gerontology

authors： Courtois Y,Hughes RC

更新日期：1976-01-01 00:00:00

abstract：:The effect of aging on plasma erythropoietin (EPO) levels after acute hemorrhage was investigated in ovariectomized (Ovx) rats. Old (22 months), middle (mid)-aged (14 months) and adult (5-6 months) Ovx rats were studied. Rats were anesthetized with ether and bled by heart puncture (5 ml/kg). They were bled again after...

journal_title：Gerontology

authors： Wang RY,Tung YF,Wang PS

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Constipation and lower urinary tract symptoms (LUTS) very frequently occur in the elderly, and several reports have suggested that dysfunction in either one of these systems may affect the other. Most studies correlating rectal and bladder dysfunction, however, have been carried out in children or young wome...

journal_title：Gerontology

authors： Charach G,Greenstein A,Rabinovich P,Groskopf I,Weintraub M

更新日期：2001-03-01 00:00:00

abstract：:Prospective surveillance of nosocomial infection was conducted at seven skilled proprietary nursing facilities in Orange County, Calif., USA. The average incidence of facility-acquired infection was 5.2 infections/1,000 patient days. The most common source of infection was urinary tract (47%), followed by respiratory ...

journal_title：Gerontology

authors： Lee YL,Thrupp LD,Friis RH,Fine M,Maleki P,Cesario TC

更新日期：1992-01-01 00:00:00

abstract：:The effect of ageing on the threshold firing rate of motor units from the first dorsal interosseous muscle was investigated. Two groups of 9 healthy male subjects between the ages of 20-29 and 60-69 years took part in the study. The threshold firing rate of motor units in young subjects showed close agreement with pre...

journal_title：Gerontology

authors： Newton JP,Yemm R,McDonagh MJ

更新日期：1988-01-01 00:00:00

abstract：:Walking and other physical activities were studied in a representative population sample of 619 70-year-old people in the city of Gothenburg, Sweden. Walking was the most common physical activity declared, and two thirds of those without an obvious disability walked 30 min or more every day. Subjects who took a daily ...

journal_title：Gerontology

authors： Frändin K,Grimby G,Mellström D,Svanborg A

更新日期：1991-01-01 00:00:00

abstract：:Empirical evidence for the conjecture that brain weight of mammals is a better predictor of life span than is body weight, is reexamined and evaluated in this paper. The original evidence was that for 63 mammalian species, log brain weight explained 79% of the log life span variance, whereas log body weight explained ...

journal_title：Gerontology

authors： Economos AC

更新日期：1980-01-01 00:00:00

abstract：:When mouse peritoneal macrophages were cultured with oxidized human low density lipoprotein (ox-LDL), storage of ceroid-like pigments was observed within the cells by light and fluorescent microscopy, and fluorescence spectrophotometry. The fluorescent products exhibit the characteristics of Schiff base structures, ha...

journal_title：Gerontology

authors： Shimasaki H,Maeba R,Tachibana R,Ueta N

更新日期：1995-01-01 00:00:00

abstract：:Aging is a complex biological phenomenon which involves progressive loss of different physiological functions of various tissues of living organisms. It is the inevitable fate of life and is a major risk factor for death and different pathological disorders. Based on a wide variety of studies performed in humans as we...

journal_title：Gerontology

authors： Chakravarti B,Chakravarti DN

更新日期：2007-01-01 00:00:00

abstract：:Morphometric measurements have been carried out on the human myenteric esophageal neurons at the ages of 20-40 and more than 70 years. The number of neurons decreases after 70 years of age, which is accompanied by an increase in the sizes of the neurons. In percentage terms the decrease in the number of neurons in the...

journal_title：Gerontology

authors： Meciano Filho J,Carvalho VC,de Souza RR

更新日期：1995-01-01 00:00:00

abstract：:A prospective study of post-operative morbidity in 258 elderly general surgical patients is reported. In 35% of patients no post-operative complications developed. Respiratory, wound and cardiac complications were the leading types of post-operative morbidity encountered, occurring in 39.5, 16.3, and 12.4% of patients...

journal_title：Gerontology

authors： Seymour DG,Pringle R

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Diabetes is common in elderly persons and is highly prevalent in Mexican Americans. Little is known about factors associated with the incidence of diabetes complications. OBJECTIVE:To examine the social, demographic and health factors associated with a 7-year incidence of diabetes complications among older ...

journal_title：Gerontology

authors： Kaushik VP,Al Snih S,Ray LA,Raji MA,Markides KS,Goodwin JS

更新日期：2007-01-01 00:00:00

abstract：:A retrospective study was made of 50 consecutive cases of bacteraemia treated in a geriatric unit. The mortality rate was 24%, the highest incidence occurring amongst the cases of hospital-acquired bacteraemia where only 1 of 7 cases survived the infection. Pyrexia, acute confusion, and falls were the commonest presen...

journal_title：Gerontology

authors： Windsor AC

更新日期：1983-01-01 00:00:00

abstract：:We studied the effects of factors associated with vascular injury on the production of endothelin-1 (ET-1) in cultured porcine aortic endothelial cells. ET-1 mRNA expression and peptide production in endothelial cells were increased by thrombin, transforming growth factor beta 1 (TGF beta 1), interleukin-1 (IL-1) and ...

journal_title：Gerontology

authors： Maemura K,Kurihara H,Morita T,Oh-hashi Y,Yazaki Y

更新日期：1992-01-01 00:00:00

abstract：:Older adults have surprisingly high levels of well-being, which has been referred to as a paradox in the past. Improved emotion regulation has been suggested to underlie these high levels of well-being. Later life is also a period with enhanced exposure to critical life events, and this comes with risks. During such t...

journal_title：Gerontology

authors： Brose A,Ebner-Priemer UW

更新日期：2015-01-01 00:00:00

abstract：:The usual features of Paget's disease of bone, e.g. large head, deafness due to involvement of the 8th cranial nerve and bowing of the legs are all well described in text books of medicine. However, some features such as platybasia with neurological deficit, involvement of the 2nd, 5th and 7th cranial nerves, hydrocep...

journal_title：Gerontology

authors： Chakravorty NK

更新日期：1978-01-01 00:00:00

abstract：:In the present study, we examined the changes that occur with age in anti-idiotype-blocked, hapten-augmentable PFC in the mucosal-associated lymph nodes (MLN and BLN) and spleen of various strains of mice. 2-month-old 129/J, AKR/J, and C57L/J mice had a high percentage of hapten-augmentable PFC in their spleen, MLN, a...

journal_title：Gerontology

authors： Szewczuk MR,Wade AW

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Falls are a significant problem for older adults. Individuals who have sustained a fall come to the attention of health care providers and are at risk of further falls. To promote the highest quality of care and reduce variation in care, a practice guideline is needed. Summarization of evidence regarding fal...

journal_title：Gerontology

authors： Moreland J,Richardson J,Chan D,O'Neill J,Bellissimo A,Grum R,Shanks L

更新日期：2003-03-01 00:00:00

abstract：:A brief review is given of the use of fluoride, mithramycin, glucagon, actinomycin D, calcitonins and diphosphonates for treatment of Paget's disease of bone. The decision regarding treatment, effectiveness of the drugs, the incidence of side effects and assessment of clinical, biochemical, histological, radiological ...

journal_title：Gerontology

authors： Chakravorty NK

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVES:Due to an increase in the percentage of older people in industrialized countries there is an increasing demand for medical care for the elderly. With advancing age, a series of structural, architectural and compositional modifications take place in the vasculature. Therefore, we analyzed the influence of pat...

journal_title：Gerontology

authors： Kröger K,Strubel G,Poser M,Pratikto T,Renzing-Köhler K,Rudofsky G

更新日期：2004-11-01 00:00:00