Abstract:
:Paraneoplastic symptoms, caused by a malignancy, but not directly related to invasion by the tumor or its metastases, are the result of a wide variety of tumor-derived biologic mediators like hormones, peptides, antibodies, cytotoxic lymphocytes, autocrine and paracrine mediators. Systemic inflammatory rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma or dermatomyositis, may increase the risk for the development of malignancies, predominantly lymphoproliferative disorders. Immunosuppressive drugs and biological agents may also be carcinogenic. However, sustained inflammatory activity seems to be the primary risk factor for malignancies in autoimmune diseases. Tumor-associated antigens may be produced by inflammatory cells and their production may be increased in rheumatoid arthritis and other autoimmune diseases.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Szekanecz Z,Szekanecz E,Bakó G,Shoenfeld Ydoi
10.1159/000314634subject
Has Abstractpub_date
2011-01-01 00:00:00pages
3-10issue
1eissn
0304-324Xissn
1423-0003pii
000314634journal_volume
57pub_type
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