Abstract:
BACKGROUND:Depressed mood may either precede mobility limitation or follow from mobility limitation. OBJECTIVE:To compare mood status among people with manifest mobility limitation, those with preclinical mobility limitation and those without mobility limitation and investigate factors explaining the association between depressed mood and mobility limitation. DESIGN:Cross-sectional. SUBJECTS:645 community-living 75- to 81-year-old people. METHODS:Depressed mood was assessed using the Centre for Epidemiologic Studies Depression Scale (CES-D, cut-off score 16); difficulty walking 500 m was assessed by self-report. Those reporting difficulty were categorised as having manifest mobility limitation. Those with no difficulty but reporting task modifications, such as reduced frequency of walking, were categorised as having preclinical mobility limitation. The association between depressed mood and mobility limitation was analysed using logistic regression analysis with gender, age, economic situation, the availability of a confidant, chronic conditions, and widespread pain as covariates. RESULTS:Depressed mood was found in 34% of subjects with manifest mobility limitation, in 26% of those with preclinical mobility limitation, and in 13% of those without mobility limitation. The unadjusted odds ratio for depressed mood was 3.43 (95% CI 2.04-5.76) among subjects with manifest mobility limitation and 2.38 (95% CI 1.52-3.73) among those with preclinical mobility limitation, compared to those without mobility limitation. Adjustment for covariates reduced the risks to 2.10 (95% CI 1.15-3.82) and 1.99 (95% CI 1.24-3.20), respectively. Widespread pain explained 28% of the increased risk of depressed mood among those with manifest mobility limitation. CONCLUSION:The dose-response relationship between depressed mood and mobility limitation suggests that both conditions may progress simultaneously and may share aetiology, at least in part. Pain may be an underlying factor in both depressed mood and mobility limitation.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Hirvensalo M,Sakari-Rantala R,Kallinen M,Leinonen R,Lintunen T,Rantanen Tdoi
10.1159/000098416subject
Has Abstractpub_date
2007-01-01 00:00:00pages
173-8issue
3eissn
0304-324Xissn
1423-0003pii
000098416journal_volume
53pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract::During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213514
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Older adults are stereotypically considered to be risk averse compared to younger age groups, although meta-analyses on age and the influence of gain/loss framing on risky choices have not found empirical evidence for age differences in risk-taking. OBJECTIVE:The current study extends the investigation of a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000487636
更新日期:2018-01-01 00:00:00
abstract::The age-related accumulation of lipopigments was determined in the adrenergic and nonadrenergic peripheral neurons of the rat using a microspectrofluorometric method and electron microscopy, 3-, 12- and 30-month-old rats were used. The rate of lipopigment accumulation was greater in nonadrenergic than adrenergic neuro...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212808
更新日期:1986-01-01 00:00:00
abstract::The biological rhythms of rectal temperature were documented in young (circadian variations) and elderly (circadian and seasonal variations) human subjects either in apparent good health or suffering from senile dementia of Alzheimer type (SDAT). All the subjects were synchronized. Data obtained showed a decrease of t...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212774
更新日期:1986-01-01 00:00:00
abstract::The distribution of sister chromatid exchange (SCE) points has been analyzed in cultured lymphocytes from three age-groups of 30 females (n = 10; young: 13-20, middle-aged: 30-55, old: 75-84 years). The observed interchromosomal SCE distribution is in good agreement with the results of previous workers, significant ag...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213147
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:Declines in physical fitness can notably affect healthy aging of older adults. Multimodal exercise training regimen such as mind-body interventions (MBIs) has been reported to mitigate these aging-related declines of physical function. This meta-analytical review aimed at pooling the effects of MBIs on phy...
journal_title:Gerontology
pub_type: meta分析
doi:10.1159/000512675
更新日期:2021-01-27 00:00:00
abstract:BACKGROUND:Recent studies have shown that vitamin D status may be relevant for physical and cognitive performance in the older population. This association may be of particular interest to older people at risk for cognitive impairment and functional decline. OBJECTIVE:The aim of this study was to determine the associa...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000355667
更新日期:2014-01-01 00:00:00
abstract::Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulat...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000371845
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Functional and physiological declines in advancing age may be significant limiting factors in reduced physical activity. Sarcopenia of aging, as a normative process or disease, cannot entirely explain reduced physical activity in the elderly. OBJECTIVE:The purpose of the study was to investigate the relatio...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022168
更新日期:2000-09-01 00:00:00
abstract::One of the problems associated with using random-source dogs to study in vivo vascular responses is their unknown background. Since aging is known to influence vascular responses, unknown variations in age could influence experimental results. The vast majority of aging studies examine arteries in vitro. This study wa...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213318
更新日期:1992-01-01 00:00:00
abstract::(Na+-K+)-ATPase is an enzyme responsible for ionic homeostasis in excitable tissues. Thus, the activity of this enzyme is essential for the maintenance of optimal function of the cerebral cortex. Although abnormalities of cerebral oxidative metabolism have been described in aging, these abnormalities do not appear to ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213123
更新日期:1983-01-01 00:00:00
abstract::Neuropsychological research contributes to a better understanding of cognitive mechanisms involved in making advantageous decisions, which is important for everyday life. Using laboratory gambling tasks, it has been demonstrated that both structural and functional brain changes can result in disadvantageous decision-m...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000248829
更新日期:2010-01-01 00:00:00
abstract::The characteristics of long-stay patients (defined as those staying more than 6 months) have been studied in a prospective series of 2,405 admissions. 5.6% become long-stay patients and they were more likely to be women, to be readmissions, to have been admitted from an old people's home, to have been non-emergency ad...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212467
更新日期:1981-01-01 00:00:00
abstract::The activity of ceruloplasmin (CP) increased 3-fold in rat blood between 1 week and 20 months of age, but the difference in CP activity of adult and old rats was only 14%, which still is statistically significant (p less than 0.01). The increase in NaCl and KCl concentrations in vitro resulted in the same exponential ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213261
更新日期:1991-01-01 00:00:00
abstract::During a winter epidemic of A/H1N1 influenza virus, we evaluated the protection conferred by vaccination of 285 residents of a nursing home. Fifteen of 204 members of the nursing staff were also vaccinated. Serological determinations were performed before and after vaccination using radial hemolysis (RH) and neuramini...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213520
更新日期:1993-01-01 00:00:00
abstract::The Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or ...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000453579
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Mild-to-moderate chronic kidney disease (CKD G3a) is prevalent in older adults. Substantial evidence suggests that individuals with advanced CKD face a high risk for common geriatric conditions, like functional impairment and cognitive decline, whereas the relationships between mild-to-moderate CKD and funct...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000484140
更新日期:2018-01-01 00:00:00
abstract::We examined the presenting features, clinical course and prognosis in relation to age in 121 patients with primary biliary cirrhosis (PBC) for a mean follow-up of 4.6 years. 35 patients (29%) were over age 65 years at presentation/detection. There was a higher proportion of patients asymptomatic of liver disease in th...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212701
更新日期:1985-01-01 00:00:00
abstract::Aging is associated with a decline in renal concentrating ability in response to dehydration-induced arginine vasopressin (AVP) release. To examine target tissue sensitivity, cortical collecting tubules (CCT) were individually microdissected from young (3 months), middle-aged (2-3 years) and old (4-5.5 years) rabbits ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213348
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Understanding comorbidity prevalence and the effects of comorbidities in older veterans with lower extremity amputations may aid in assessing patient outcomes, resource use, and facility-level quality of care. OBJECTIVES:To determine the degree to which adding outpatient to inpatient administrative data sou...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000101703
更新日期:2007-01-01 00:00:00
abstract::We have previously shown that lymphocytes from Alzheimer's disease (AD) patients are hypersensitive to ionising radiation, as revealed by their higher levels of dicentrics than those from age-matched, normal individuals. We have now examined the sensitivity of these cells to N-methyl-N-nitrosourea or methyl methanesul...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213539
更新日期:1993-01-01 00:00:00
abstract::The rates of collagen fibril formation are, under otherwise identical conditions, a function of the age of the acid-soluble rat tail tendon collagen utilized. The rate is most rapid with young adult (165 day) collagen, which exhibits no induction period before collagen multimerization begins. In contrast, 21-day colla...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212248
更新日期:1978-01-01 00:00:00
abstract::To determine the influence of age, disease and other factors on anthropometric indices in elderly subjects aged 70 years and above, body mass index (BMI), arm muscle circumference (AMC), corrected arm muscle area (CAMA), fat-free mass (FFM) and total body fat (TBF) were determined in a random sample of 990 Chinese men...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213679
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Proxy decision-making may be flawed by inaccurate perceptions of risk. This may be particularly true when older adults are the targets of the decisions, given the pervasive negative stereotypes about older adults. METHODS:In study 1, individuals aged 18- to 87 years (as target persons) as wel...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000494352
更新日期:2019-01-01 00:00:00
abstract::Anaerobic bacteremia occurred in 68 patients over the age of 60 in a university hospital. These elderly patients were more likely than younger patients to have an underlying malignancy. Anaerobes involved included Bacteroides fragilis group (64 isolates), Bacteroides melaninogenicus group (11) and Clostridium species ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213011
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Despite declines in cognitive abilities, older adults often perform comparable to younger adults in everyday tasks [J Am Geriatr Soc 1999;47:172-183]. Older adults may compensate for cognitive declines by using more efficient strategies. People often improve their efficiency by switching from an algorithmic ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000446277
更新日期:2016-01-01 00:00:00
abstract::L-tryptophan (L-T) was added at a dose of 150-450 mg daily to eight Parkinsonian patients who developed visual hallucinations with paranoidal features under L-dopa (L-D) treatment (112.5-75 mg daily) in combination with alpha-methyldopa hydrazine (12.5-75 mg daily). In six patients L-T ameliorated the symptomatology b...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212220
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Recruiting older adults, their family members and their home care workers as participants in research studies is particularly complicated. This might be due to medical or cognitive problems of the older adult as well as the high workload and shortage of time experienced by caregivers. The present study compa...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000366161
更新日期:2015-01-01 00:00:00
abstract::To investigate the mechanisms of age-related decline in synthesis of adrenal androgen, we studied the contents of cortisol (F) and dehydroepiandrosterone (DHEA) and the amounts of cytochrome P450 17 alpha-hydroxylase (P450c17) mRNA and cytochrome P450 11 beta-hydroxylase (P450c11) mRNA in young (1 year old) and senesc...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213270
更新日期:1991-01-01 00:00:00
abstract::The kinetics of cell proliferation and sister chromatid exchanges (SCE) were studied in blood lymphocytes treated by mitomycin C (MMC) in young and old human donors. In both the young and old donors MMC inhibited cell proliferation. Spontaneous SCE frequency was not age-dependent. In young donors, MMC induced a dose-r...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212658
更新日期:1984-01-01 00:00:00