Abstract:
:The kinetics of cell proliferation and sister chromatid exchanges (SCE) were studied in blood lymphocytes treated by mitomycin C (MMC) in young and old human donors. In both the young and old donors MMC inhibited cell proliferation. Spontaneous SCE frequency was not age-dependent. In young donors, MMC induced a dose-related linear increase in SCE frequency. In old donors a significantly reduced SCE rate was induced by 80 ng/ml of MMC, suggesting an altered SCE response to mutagen. As SCE represent some form of DNA repair, the results can be interpreted as an indication of a defective DNA repair in aging human lymphocytes.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Musilová J,Michalová K,Pacovský Vdoi
10.1159/000212658subject
Has Abstractpub_date
1984-01-01 00:00:00pages
365-70issue
6eissn
0304-324Xissn
1423-0003journal_volume
30pub_type
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