Abstract:
:The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased the potassium content in both the nucleus and cytoplasm in terms of dry mass fraction, whereas the sodium concentration remained unchanged. The Na+/K+ ration increased significantly in both cell compartments. The chloride content of the nuclei decreased slightly. If one supposes just 1--2% rehydration of the old cytoplasm, the decrease of the total ionic strength may be of considerable extent, it may even reach the values obtained in young adult animals. The results are interpreted in terms of a recently developed 'membrane hypothesis' of aging.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Zs-Nagy I,Pieri C,Giuli C,Del Moro Mdoi
10.1159/000212326subject
Has Abstractpub_date
1979-01-01 00:00:00pages
94-102issue
2eissn
0304-324Xissn
1423-0003journal_volume
25pub_type
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