Abstract:
:We studied the effects of factors associated with vascular injury on the production of endothelin-1 (ET-1) in cultured porcine aortic endothelial cells. ET-1 mRNA expression and peptide production in endothelial cells were increased by thrombin, transforming growth factor beta 1 (TGF beta 1), interleukin-1 (IL-1) and tumor necrotizing factor alpha (TNF alpha). The analysis of the enhancer/promoter region of the human ET-1 gene showed that the ET-1 gene transcription is regulated in a cell-specific manner and is activated by thrombin, TGF beta 1 and IL-1. These results suggest that the production of ET-1 in endothelial cells is regulated by factors associated with platelet aggregation, macrophage infiltration and the formation of atherosclerotic lesions.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Maemura K,Kurihara H,Morita T,Oh-hashi Y,Yazaki Ydoi
10.1159/000213360keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
29-35eissn
0304-324Xissn
1423-0003journal_volume
38 Suppl 1pub_type
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