Abstract:
:The effects of ovine corticotropin releasing factor (o-CRF) on the secretions of ACTH, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were studied in the healthy young and elderly male individuals. o-CRF caused significant elevations of plasma ACTH, cortisol and DHEA concentrations, in all subjects. Moreover, there were no significant differences in the time-dependent responses of plasma ACTH, cortisol and DHEA to o-CRF between the young and elderly male individuals. o-CRF showed no significant rise of plasma DHEA-S, in all subjects. We conclude that the pituitary-adrenal sensitivity to the hypothalamic CRF in the elderly does not change with aging.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Ohashi M,Fujio N,Kato K,Nawata H,Ibayashi Hdoi
10.1159/000212812subject
Has Abstractpub_date
1986-01-01 00:00:00pages
335-9issue
6eissn
0304-324Xissn
1423-0003journal_volume
32pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract:AIM:To investigate acceptance and usage issues in relation to Telehealth products as used by frail older clients of the Transition Care Program and their carers. METHOD:The study design was a quasi-randomised controlled clinical trial. A stratified random sample of participants was allocated to one of five groups usin...
journal_title:Gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000335033
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Declines in physical fitness can notably affect healthy aging of older adults. Multimodal exercise training regimen such as mind-body interventions (MBIs) has been reported to mitigate these aging-related declines of physical function. This meta-analytical review aimed at pooling the effects of MBIs on phy...
journal_title:Gerontology
pub_type: meta分析
doi:10.1159/000512675
更新日期:2021-01-27 00:00:00
abstract::Mitochondrial abnormality in the skeletal muscles of 13 patients with myotonic dystrophy was analyzed by both histochemical and molecular biologic methods. Nine of 13 patients had ragged-red fibers (50 +/- 116 per 10,000 muscle fibers, mean +/- SD), and 10 patients had cytochrome c oxidase-negative fibers (41 +/- 90 p...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213303
更新日期:1992-01-01 00:00:00
abstract::Normal circulating red blood cells (RBCs) and platelets have been shown to have small amounts of IgG on their membranes. The cell-bound IgG may be cytophilic (IgG nonspecifically adsorbed from the plasma) and/or IgG autoantibody. It has been suggested that most of the RBC-bound IgG is on older RBCs and is an autoantib...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000213252
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Functional and physiological declines in advancing age may be significant limiting factors in reduced physical activity. Sarcopenia of aging, as a normative process or disease, cannot entirely explain reduced physical activity in the elderly. OBJECTIVE:The purpose of the study was to investigate the relatio...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022168
更新日期:2000-09-01 00:00:00
abstract::Lymphopenia is a common finding in old people admitted to medical and psychiatric wards. We describe a pilot study of the clinical associations, and prognostic significance of lymphopenia in elderly persons admitted to acute medical and psychiatric wards. Consecutive patients admitted to acute medical and psychiatric ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022003
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:It is known that growth factors play a role in ageing and atherogenesis, and insulin develops mitogenic activity in vitro. OBJECTIVES:This study focuses on the pathway by which insulin induces proliferation and mobility in vascular smooth muscle cells (SMCs) compared with that of insulin-like growth factor-...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000085118
更新日期:2005-07-01 00:00:00
abstract::Period life expectancy is one of the most used summary indicators for the overall health of a population. Its levels and trends direct health policies, and researchers try to identify the determining risk factors to assess and forecast future developments. The use of period life expectancy is often based on the assump...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000500955
更新日期:2020-01-01 00:00:00
abstract::Fishes exhibit a 'determinate' type of growth in short-lived species of warmer regions and an 'indeterminate' type in long-lived species of colder regions. Growth is measured in units of length and weight and is best represented as the specific growth rate. The relationship between weight and length provides an index ...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000213581
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Old age has traditionally been considered to begin at age 65. The improving health and functional status observed among older people may necessitate reevaluation of this cut-off point. OBJECTIVE:To present the changing prevalence of common geriatric syndromes, functional parameters, common disease status an...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000335238
更新日期:2012-01-01 00:00:00
abstract::During the past decade, controversy has raged about the necessity of renal biopsy for the management of the idiopathic nephrotic syndrome. The debate has centered on whether a precise diagnosis is imperative for steroid treatment or whether such therapy can be given blindly. The above question has not been addressed i...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213514
更新日期:1993-01-01 00:00:00
abstract::Differences between women and men in terms of gender gaps at late stages of their lives are the focus of this mini-review. We approach the matter by taking up the position of complex yet promising standpoints, the bio-psycho-social perspective on the one hand and approaches of developmental psychology on the other. Li...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000323154
更新日期:2011-01-01 00:00:00
abstract::Recently, Granacher et al. (2010) proposed an intergenerational approach to promoting balance and strength for fall prevention in children and elderly subjects together. Although this sounds like a stimulating idea, its effectiveness for fall prevention in both groups has yet to be demonstrated. Undoubtedly, fall prev...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000322930
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Falls are a significant problem for older adults. Individuals who have sustained a fall come to the attention of health care providers and are at risk of further falls. To promote the highest quality of care and reduce variation in care, a practice guideline is needed. Summarization of evidence regarding fal...
journal_title:Gerontology
pub_type: 杂志文章,meta分析
doi:10.1159/000067948
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Recruiting older adults, their family members and their home care workers as participants in research studies is particularly complicated. This might be due to medical or cognitive problems of the older adult as well as the high workload and shortage of time experienced by caregivers. The present study compa...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000366161
更新日期:2015-01-01 00:00:00
abstract::To develop a new method for accurately predicting creatinine clearance (Ccr) in the debilitated elderly without urine collections, the total muscle volume of both thighs (MV thigh), as a new predictive parameter, was calculated using computed tomography in 68 debilitated patients aged 61-92 years. A regression line be...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213705
更新日期:1995-01-01 00:00:00
abstract::The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212326
更新日期:1979-01-01 00:00:00
abstract::Taurine (TAU) is thought to be a neuromodulator or an inhibitory neurotransmitter in the mammalian brain. In the periphery, TAU is involved in a wide spectrum of physiological functions. One of the most important putative physiological function of TAU is the modulation of cardiovascular activity including blood pressu...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213171
更新日期:1990-01-01 00:00:00
abstract::Age differences in decision-making are of theoretical interest and have important practical implications, but relevant lines of work are distributed across multiple disciplines and often lack integration. The present review proposes an overarching conceptual framework with the aim of connecting disjointed aspects of t...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000485247
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Aging changes in different body system are well described, but few studies have considered the relationship between them. OBJECTIVE:The purpose of this study was, therefore, to investigate the interrelationships between markers of aging in different parts of the body. METHODS:A cross-sectional study design...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022068
更新日期:1999-01-01 00:00:00
abstract::The concentrations of noradrenaline and adrenaline were studied in specimens of the posterior tibial artery obtained from 18 subjects at postmortem examination. The mean noradrenaline concentration was 167 ng/g artery (range 17-449 ng/g) and the mean adrenaline concentration was 5 ng/g (range 0--21 ng/g). There was no...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212263
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:It is known from clinical practice and observational studies that elderly patients with a diagnosis of inflammatory rheumatic diseases (IRD) bear a significantly increased risk for cardiovascular diseases such as coronary artery disease (CAD) and heart failure. The molecular mechanism, however, is still not ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000471763
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:There is a need for simple clinical tools that can objectively assess the fall risk in people with dementia. Wearable sensors seem to have the potential for fall prediction; however, there has been limited work performed in this important area. OBJECTIVE:To explore the validity of sensor-derived physical ac...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000363136
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Despite declines in cognitive abilities, older adults often perform comparable to younger adults in everyday tasks [J Am Geriatr Soc 1999;47:172-183]. Older adults may compensate for cognitive declines by using more efficient strategies. People often improve their efficiency by switching from an algorithmic ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000446277
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Constipation and lower urinary tract symptoms (LUTS) very frequently occur in the elderly, and several reports have suggested that dysfunction in either one of these systems may affect the other. Most studies correlating rectal and bladder dysfunction, however, have been carried out in children or young wome...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000052776
更新日期:2001-03-01 00:00:00
abstract::Empirical evidence for the conjecture that brain weight of mammals is a better predictor of life span than is body weight, is reexamined and evaluated in this paper. The original evidence was that for 63 mammalian species, log brain weight explained 79% of the log life span variance, whereas log body weight explained ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212399
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Mortality in the intensive care unit (ICU) rises with age, a high basal serum cortisol and a small response to adrenocorticotropin (ACTH) stimulation. Even slight impairment of the adrenal response during severe illness can be lethal. OBJECTIVES:To determine if age is associated with changes in basal or sti...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000048932
更新日期:2002-03-01 00:00:00
abstract::Glutamine synthetase (GS) activity was measured in whole brain, different brain areas, liver and heart of 23- to 26-month-old rats, and then compared to matched animals of 3 months. A significant increase of GS activity was found in whole brain (25%) of old rats, as well as in all brain areas studied, but particularly...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212686
更新日期:1985-01-01 00:00:00
abstract:INTRODUCTION:Many falls in older adults occur during walking and result in lateral falls. The ability to perform a recovery step after balance perturbation determines whether a fall will occur. AIM:To investigate age-related changes in first recovery step kinematics and kinematic adaptations over a wide range of later...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000505649
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial. It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome. OBJECTIVE:The purpose of this study was to determine whether age in...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000323080
更新日期:2012-01-01 00:00:00