Aging is without effect on the pituitary-adrenal axis in men.

Abstract:

:The effects of ovine corticotropin releasing factor (o-CRF) on the secretions of ACTH, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were studied in the healthy young and elderly male individuals. o-CRF caused significant elevations of plasma ACTH, cortisol and DHEA concentrations, in all subjects. Moreover, there were no significant differences in the time-dependent responses of plasma ACTH, cortisol and DHEA to o-CRF between the young and elderly male individuals. o-CRF showed no significant rise of plasma DHEA-S, in all subjects. We conclude that the pituitary-adrenal sensitivity to the hypothalamic CRF in the elderly does not change with aging.

journal_name

Gerontology

journal_title

Gerontology

authors

Ohashi M,Fujio N,Kato K,Nawata H,Ibayashi H

doi

10.1159/000212812

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

335-9

issue

6

eissn

0304-324X

issn

1423-0003

journal_volume

32

pub_type

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