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Effect of lead on the biological activity of calmodulin in rat brain.

Abstract：

:In the present investigation, we observed that lead in vitro activates calmodulin at lower concentrations, and the maximum activation was observed at 30 microM concentration. In vivo lead exposure (50 mg/kg body weight, intragastrically) for a period of 8 weeks also stimulated the activity of calmodulin by 45%. The addition of trifluoperazine resulted in partially inhibiting the lead-stimulated calmodulin activity, whereas the calcium-stimulated calmodulin activity was completely inhibited by trifluoperazine. Studies with purified calmodulin from the brain of control and lead-treated animals indicate that approximately 4 mole of calcium was present bound/mole of calmodulin in control animals and this fraction was reduced in lead-treated animals to approximately 3 mole of calcium/mole of calmodulin. Lead distribution revealed that approximately 68% of the total lead present was bound to calmodulin and the remaining 32% present was bound to non-calmodulin binding sites following lead exposure. These results indicate that in vivo lead exposure is able to displace and mimic the action of calcium and this may constitute a molecular mechanism of lead neurotoxicity.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Sandhir R,Gill KD

doi

10.1006/exmp.1994.1026

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

69-75

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(84)71026-4

journal_volume

61

pub_type

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