Abstract:
:Dibasic esters (DBE) solvent has been demonstrated to induce a mild degeneration of the olfactory, but not the respiratory epithelium of the rat nasal cavity following a 90-day inhalation exposure. Previous work has demonstrated that acid phosphatase release is a reliable index of DBE-induced cytotoxicity in an in vitro system of rat nasal explants. In the present study, rat nasal explants were examined microscopically and ultrastructurally following incubation in varying concentrations of a representative DBE, dimethyl adipate (DMA). DMA-induced microscopic and ultrastructural changes in rat nasal explants correlated well with biochemical perturbations associated with DBE exposure in a previous study. In both studies, olfactory epithelium was more susceptible to DMA-induced toxicity than respiratory epithelium and DMA-induced nasal toxicity was attenuated by pretreatment with a carboxylesterase inhibitor. The results of this study support the hypothesis that DBE and potentially other inhaled organic esters induce nasal toxicity via a common mechanism, carboxylesterase-mediated production of toxic acid metabolites. It was established that carboxylesterase-rich sustentacular cells are the primary target cells for DBE toxicity in rat nasal explants. It was proposed that degeneration of nasal olfactory sensory cells observed in rats following 90-day inhalation exposure to DBE may be secondary to necrosis and loss of sustentacular cells.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Trela BA,Frame SR,Bogdanffy MSdoi
10.1016/0014-4800(92)90037-ckeywords:
subject
Has Abstractpub_date
1992-06-01 00:00:00pages
208-18issue
3eissn
0014-4800issn
1096-0945pii
0014-4800(92)90037-Cjournal_volume
56pub_type
杂志文章abstract::Attempts to establish a tissue bank from autopsy samples have led to uncovering of the secrets of many diseases. Here, we examined the length of time that the RNA from postmortem tissues is available for microarray analysis and reported the gene expression profile for up- and down-regulated genes during the postmortem...
journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/j.yexmp.2016.05.007
更新日期:2016-06-01 00:00:00
abstract::The morphology of Gleason 4 prostate cancer (PCa) can be subdivided into cribriform and non-cribriform patterns. A large body of evidence has shown that pattern 4 cribriform PCa (especially non-glomeruloid type) is associated with adverse pathologic features and clinical outcomes compared with non-cribriform pattern 4...
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/j.yexmp.2017.02.013
更新日期:2017-04-01 00:00:00
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更新日期:2021-01-19 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/0014-4800(85)90030-9
更新日期:1985-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2015-08-01 00:00:00
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journal_title:Experimental and molecular pathology
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doi:10.1006/exmp.1999.2263
更新日期:1999-08-01 00:00:00
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journal_title:Experimental and molecular pathology
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更新日期:1991-10-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/j.yexmp.2004.04.006
更新日期:2004-10-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章,评审
doi:10.1016/j.yexmp.2011.04.017
更新日期:2011-08-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1006/exmp.1995.1040
更新日期:1995-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Experimental and molecular pathology
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pub_type: 杂志文章
doi:10.1016/j.yexmp.2009.06.001
更新日期:2009-12-01 00:00:00
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journal_title:Experimental and molecular pathology
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更新日期:2011-04-01 00:00:00
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doi:10.1016/j.yexmp.2006.10.002
更新日期:2007-02-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/0014-4800(83)90100-4
更新日期:1983-02-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/j.yexmp.2011.05.003
更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章,评审
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更新日期:2003-04-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/0014-4800(88)90072-x
更新日期:1988-06-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1006/exmp.1994.1027
更新日期:1994-10-01 00:00:00